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Cytokines found to have up-regulated in cells were measured in serum and lung tissue of rats exposed to large tidal volume ventilation. For investigating the intracellular pathway of cytokine up-regulation in VILI, exogenous TNF-α or H2O2 was added to culture media of alveolar epithelial cells. Cytokines were then measured. To explore the role of oxidant stress in VILI, N-acetylcysteine, as an anti-oxidant, was used in vitro and in vivo.

我们在体外培养的上皮细胞中加入外源性肿瘤坏死因子、过氧化氢或N-乙酰半胱氨酸,观察细胞因子的变化。N-乙酰半胱氨酸亦被投入大鼠呼吸机诱导损伤模型,观察用药后细胞因子的变化。

NAC also blocked the up-regulation of TGF-β in in vivo model of VILI. Conclusion TGF-β1 and TGF-β2 were up-regulated in VILI. Oxidant injury mediated up-regulation of TGF-β in VILI. NAC, which attenuated oxidant injury and blocked TGF-β up-regulation in VILI, could be a future therapeutic strategy in VILI.

结论TGF-β1和TGF-β2在通气机所致损伤中的表达增加并在血清中上调;TGF-β上调的机制与氧自由基损伤有关但与肿瘤坏死因子无关;N-乙酰半胱氨酸可对抗氧自由基损伤,能阻断TGF-β的上调,可能成为呼吸机相关损伤的一种新治疗途径。

Methods GR mRNA was meaanred by Northern blots and hybridizations. GR binding activity was measured by Wrang's method.

方法采用分子生物学杂交技术、Northern印迹法测定胎鼠及其二种主要细胞的GR mRNA及Wrang法测定外源性糖皮质激素对胎鼠及二种主要细胞GR结合活性的作用。

Objective:To observe the pulmonary protective effect and impacts of local chest radiotherapy in corpore levels of connective tissue growth factorand platelet-derived growth factor after Qingzaojiufei soup treatment in patients with advanced and mediate chest tumor.

目的:观察清燥救汤对局部中晚期胸部肿瘤放射治疗的保护作用及对结缔组织生长因子、血小板源性生长因子在体内水平的影响。

Breath fails (Respiratory Failure, because lung aerates,RF) is obstacle of function of insufficient, dispersion and lung aerate / blood stream scale is maladjusted wait for an element, low oxygen blood appears when making static interest position issues breath disease and carbon dioxide retention, cause a series of physiology functions and metabolization thereby disorder clinical and integrated proof.

概要: 呼吸衰竭(respiratory failure,RF)是由于通气不足、弥散功能障碍和通气/血流比例失调等因素,使静息状态下呼吸时出现低氧血症和二氧化碳潴留,从而引起一系列生理功能和代谢紊乱的临床综合征。

As it can be ascertained, the horse lung is comparable to that of man.

就目前的研究程度而言,马的比得上人类的

Objective To evaluate the equivalence of compression atomized and ultrasonic atomized inhalation for patients with chronic obstructive pulmonary disease.

目的 观察不同雾化吸入方法对慢性阻塞性疾病患者功能及血气的影响。

Objective To investigate the precautionary effect of early atomizing inhalation of LMWH on rats of COPD.

目的 探讨早期雾化吸入低分子肝素对慢性阻塞性疾病的保护作用。

Abstract] Objective To explore a safe and effective strategy in the management of giant bullae.

目的 观察大疱内固定减容术治疗大疱的疗效。

Objective:To analysis some major problems of anesthetic management in patients with bullae undergoing thoracoscopic instrumentation.

目的探讨胸腔镜下大泡切除、修补术麻醉管理中应注意的问题。

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