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Objectives To study the expressions of STAT1 and PDGF in lung tissue of pulmonary fibrosis model induced by bleomycin in rats, and discuss the possible mechanism.Methods Thirty Wistar rats were randomly divided into two groups (15 in each group), they were bleomycin group and control group.①The BLM group was intratracheally instilled with belomycin (5mg/kg);② NS group was intratracheally instilled with saline (5mg/kg).

目的 观察纤维化鼠组织信号转导和转录活化因子1(STAT1)和血小板源性生长因子表达的变化,探讨其在纤维化的作用机制方法 30只Wistar大鼠随机分博莱霉素组和对照组,①BLM组:气管内灌注BLM(5mg/kg)诱导纤维化;②NS组:气管内灌注NS。

Methods Twelve healthy volunteers, of them 5 smokers and another 7 nonsmokers, underwent right middle lobe bronchoalveolar lavage and transbronchial instillation of KLH into lingula. Dimeric and monomeric IgA, albumin and cellular differential count in BALF were measured. Serum anti-KLH IgA was tested at various days after instillation of antigen.

对12名健康志愿者(其中5名吸烟)行右中叶灌洗,分析灌洗中IgA型别、细胞分类计数、白蛋白含量,并从左叶内注入钥孔血蓝蛋白抗原,观察局部抗原免疫后血循环中特异性IgA抗体的免疫应答能力。

Prenatal EGF can improve pulmonary hypoplasia in the Nitrofen-induced CDH rat model, which was manifested as increased Lw/Bw and more mature histological and morphometrical pulmonary appearances. Moreover, EGF can promote type Ⅱ pneumocytes differentiation and increase their amounts, thus increase the production of surfactant.

EGF对大鼠先天性膈疝模型发育不良具有明显的改善作用,不仅可以促进组织生长,表现在重量/体重增加,组织形态得到明显改善,而且对Ⅱ型细胞有明显的促分化作用,Ⅱ型细胞密度增加,功能增强;而且随着EGF剂量的增加作用加强,当剂量为150ug/只(600ug/kg)时,作用较为明显。

Cases displayed simple slice infiltrative focus:③ Six eases with fungal pneumonia: 4 cases were pulmonary aspergillosis, in which 2 cases displayed multiple-slice shadow with cavity formation and 1 ease displayed multiple-tubercle shadow and 1 ease displayed single conglomerate shadow. 2 eases of pulmonary mucormycosis displayed diffuse spot slice and small slice shadow with partial fusion.

真菌性炎6例:4例为曲霉菌病,2例表现为两多发片状影伴空洞形成、1例表现为多发小结节影、1例表现为单发团块状影;2例毛霉菌病表现为两弥漫性斑片状、小片状影,部分融合。

Malondialdehyde production and total superoxide dismutase activity in samples of nondependent lung and dependent lung were detected and analysed in both groups on time of OLV 3hr and OLV 6hr to determine whether long-term OLV led to injury of the nondependent lung and whether the injury would be deteriorated by low-dose ALM.

通过对OLV 3hr及OLV 6hr时两组实验犬无通气与通气组织标本中丙二醛含量及总超氧化物歧化酶活力的测定,观察长时间OLV是否引起无通气组织损伤,并同时探讨小剂量ALM对无通气组织损伤的影响。

The Western blot results were consistent with those of immunohistochemical method. CONCLUSION: p38 MAPK expression increases in alveolar and airway epithelial cells in LPS induced acute lung injury rat models. The activation of p38 MAPK is found in most lung tissues, suggesting that p38 MAPK participates in the signal transduction in inflammatory and noninflammatory cells.

LPS诱发的大鼠急性损伤模型中,磷酸化p38 MAPK在气道和组织内表达增加,p38 MAPK的激活见于组织内多数细胞,提示内炎性和非炎性细胞均有p38 MAPK信号分子的激活。

Methods Routine and impulse oscillometry pulmonary function tests,including VC%,FVC% FEV1.0,FEV1.0/FVC%,PEF,FEF50,FEF25 and diffusing capacity of CO,were conducted in 35 normal subjects,38 patients with pulmonary fibrosis(Group 1) and 18 patients suffering from chronic obstructive pulmonary disease and pulmonary fibr...

方法单纯间质纤维化病人38例,慢性阻塞性疾病合并间质纤维化病人18例和健康人35例分别测定常规功能,包括活量、1秒量(FEV1.0)、1秒率(FEV1.0/FVC%);呼气峰流速、50%用力呼气流速(FEF50);25%用力呼气流速(FEF25)和一氧化碳弥散量。

It is a good method to cure COPD in paracmasis by the traditional Chinese medicine Bailing capsule and the medical gymnastics,to the patients of insufficiency of QI of the lung and kidney especially,the method can improve the disease resistance and lung ventilation.

中药百令胶囊结合康复医疗体操是缓解期慢性阻塞性疾病患者,尤其是肾气虚者提高免疫力,改善功能的良好方案。

Results CT features of wet lung included 4 types:(1)the interstitial type in 10 cases,appeared as thicknees and blurring of the shadow of pulmonary blood vessels;(2)the disseminated consolidation type in 15 cases appeared as scattered mottling or small patch foci with slight high density in pulmonary paren...

结果CT表现分为4型:(1)间质型10例,血管影增粗、模糊,(2)弥漫实变型15例:实质内散在斑点状、小片状稍高密度灶;(3)云雾型20例,呈磨砂玻璃改变的云雾状稍高密度灶;(4)节段实变型15例,大片状或呈叶、段分布的高密度灶。结论螺旋CT能够明确显示创伤性湿的部位、类型、范围和发现合并伤的存在,是目前诊断创伤性湿有效的检查手段之一。

Methods Ddimer levels were determined by enzymelinked immunoabsorbent assay in patient with suspicion of pulmonary embolism,and carries on for half year to those patients to make a followup visit to see whether they have the symptom of pulmonary embolism or deep phlebothrombosis.

摘 要]目的:探讨D二聚体在排除栓塞诊断中的临床价值。方法:使用ELISA法对可疑栓塞患者血浆中纤维蛋白降解产物DD进行检测,并对这些可疑栓塞患者进行半年的随访,了解是否有栓塞或深静脉栓塞的症状。

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