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Except for control group, rats in the other groups were intratracheally administered with bleomycin. Animals in pulmonary fibrosis model groups were sacrificed on day 3, 7, 14, 28 and 56. The sections of the right lung were stained by HE, Masson and sirius red. The left lung was weighed and its hydroxyproline content was assayed. The mRNAs of TGF-β1, MMP-9 and TIMP-1 in the lung homogenate were measured by semi-quantitative RT-PCR.

除N组外,其余各组采用气管内注入BLM致大鼠纤维化模型,分别于3、7、14、28、56d处死各组大鼠,右行苏木精-依红、Masson胶原及天狼猩红染色,测定左经脯氨酸的含量RT-PCR法半定量测定转化生长因子-1(TGF-β1)、基质金属蛋白酶-9(MMP-9)和基质金属蛋白酶组织抑制物-1(nMP-1)mRNA在内的表达。

50Mg each of the above mentioned prepared dust particulates was injected intratracheally into each rat.

各组大鼠经气管注入50mg/只,染尘后1、3、6、12月分批剖检,测定全湿重、干重、胶原蛋白含量和门淋巴结病理检查。

In SAP rat, labiatae can alleviate the pathological detriments of pancreas and lung, can reduce the levels of endothelin-1 in serum, and is beneficial to lung injury.

丹参能够减轻SAP大鼠胰腺和组织病理损伤,降低血清和组织中ET-1水平因而对SAP损伤具有保护作用。

Dry that injured the windpipe and skins and the defenced of "lanket of Cilla-mucus"and reduced the expression of bcl-2 gene, which was related to the mechanisms of Cool??Dry.

凉燥伤、伤津,致气道&纤毛-黏液毯&局部御邪屏障受损;津凝滞于,以致宣输失司则皮肤失养。

ConclusionIt has first provided the evidences of CoolDry that injured the windpipe and skins and the defenced of "lanket of Cilla-mucus"and reduced the expression of bcl-2 gene, which was related to the mechanisms of CoolDry.

凉燥伤、伤津,致气道&纤毛-黏液毯&局部御邪屏障受损;津凝滞于,以致宣输失司则皮肤失养。本结果为凉燥致病提供实验资料。

ConclusionIt has first provided the evidences of Cool Dry that injured the windpipe and skins and the defenced of "lanket of Cilla-mucus"and reduced the expression of bcl-2 gene, which was related to the mechanisms of Cool Dry.

凉燥伤、伤津,致气道&纤毛-黏液毯&局部御邪屏障受损;津凝滞于,以致宣输失司则皮肤失养。本结果为凉燥致病提供实验资料。

Two lung have bottom of lobar needle, lung and two side each.

各有尖、底和两个侧面。

It is oftcn referred to as lobar pneumonia because it frequentlyspreads in a lobar.or segmented manner throughout the lung.

3经常把它称作大叶性炎,因为它常以一叶或一段的方式扩散到全

Majo et al47 studied lungs that were obtained at surgery from the following three groups of subjects: nonsmokers, smokers with no evidence of emphysema or lung function impairment, and smokers with both emphysema and abnormal lung function.

Majo等人对以下三组人群的组织样本进行研究:不吸烟人群,无气肿或功能损伤的吸烟人群,既有气肿又有功能异常的吸烟人群。

The thickness of alveolar wall, the areas of mesenchyma in lung tissue were measured by HE staining. Immunohistochemical evaluation was to detect the expression of TNF-α, TGF-β1, FN protein.

灌药后第7、14、28天分组处死动物,提取组织,HE染色行泡炎、纤维化程度分级及免疫组化测定组织TNF-α、TGF-β_1、FN蛋白表达。

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