肥大

ABSTRACTS : Rat diabetes model was duplicated through streptozotocin intraperitoneal injection.Not only effect of Zhixiaotongmaining on DM at earlier stage,effects of the content change of NO and endotheliolysin on the formation of hypernephrotrophy and high filtration were also studied.

摘 要：肾脏肥大、高滤过是糖尿病肾病早期的病理生理基础，采用腹腔注射链脲佐菌素复制糖尿病大鼠模型，研究止消通脉宁对DM大鼠肾脏肥大和高滤过的治疗作用，及一氧化氮和内皮素含量变化规律在DM早期肾脏肥大、高滤过率形成过程中的意义。

Candida colonisation did not enhance oalbumin permeation in mast cell deficient W/W mice but did in congenic littermate control +/+ mice. Reconstitution of mast cells in W/W mice by transplantation of bone marrow deried mast cells restored the ability to increase oalbumin permeation in response to Candida colonisation.

念珠菌定植不加强肥大细胞缺陷W/W小鼠的蛋白通透性，而其同系同窝对照+/+小鼠则有加强，W/W小鼠通过骨髓肥大细胞移植重建肥大细胞功能可恢复念珠菌定植后对卵白蛋白通透性的增强作用。

Calcium deficiency can cause night terrors, night waking,夜啼, muscle cramps infants, tetany, as well as congenital laryngeal chondromalacia ointment, baby should be given calcium and vitamin D, and more sun; if necessary, intravenous injection of 2, rhinitis , deviation of nasal septum, nasal polyps, adenoidal hypertrophy, tonsillar hypertrophy, hypertrophic uvula, etc., can be caused by nasopharyngeal cavity narrow, stuffy nose, respiratory congestion, lack of oxygen, affecting sleep, should be to check the diagnosis and treatment of facial features .

缺钙可引起夜惊、夜醒、夜啼、肌肉抽筋儿、手足搐搦以及先天性喉软膏软化症，应给孩子补钙和维生素D，并多晒太阳；必要时静脉注射2、鼻炎、鼻中隔偏曲、鼻息肉、腺样体肥大、扁桃腺肥大、悬雍垂肥大等，均可造成鼻咽腔狭窄，鼻塞，呼吸不畅，缺氧，影响睡眠，应去五官科检查诊治。

Cardiac hypertrophy is one of adaptive responses of the heart to a variety of pathological stimuli, including hypertension, myocardial infarction, congenital heart disease, heart valvula disease, and perturbations in sarcomeric function due to altered expression or mutations of contractile proteins. Increase in wall tension and hormonal stimuli are thought to directly activate various membrane-bound receptors and signal transduction cascade within cardiomyocytes resulting in the activation of immediate early genes and responsive genes such as c-jun, c-fos, c-myc, egr-1, ANF, BNP. Then the expression of construction proteins such as MLC-1, skeletal α-actin was unregulated.

中文题名hhlim基因的表达调节及其与心肌细胞肥大发生之间的关系副题名外文题名 hhlim gene expression regulation and its role in development of cardiomyocyte hypertrophy 论文作者郑斌导师温进坤韩梅学科专业生物化学与分子生物学研究领域\研究方向学位级别博士学位授予单位河北医科大学学位授予日期2003 论文页码总数106页关键词心肌细胞肥大基因表达心肌肥厚 hhlim基因馆藏号BSLW /2003 /R542.2 /33 心肌细胞肥大是高血压、心脏瓣膜病、急性心肌梗塞及先天性心脏病等临床常见疾病的一种并发症，是心肌细胞对多种病理刺激的一种适应性反应。

RESULTS : The hypertrophic cardiomyocyte NTPase Vmax values at 1 week group and 4 week group were all increased significantly in both of ATP and GTP as substrates with much higher argumental extent in early hyper group; their Km values were kept constant in early hyper group and were decreased only in late hyper groups.

结果：早、晚期肥大组心肌细胞核被膜NTPase最大反应速率以ATP为底物时较对照组增加25%～62%(P＜0.01)，以GTP为底物时增加8%～44%(P＜0.01)，其中晚期肥大组NTPase最大反应速率增加幅度低于早期组。早期肥大组细胞核被膜NTPase Km值不变，晚期组NTPase Km值下降，以ATP和GTP为底物时晚期肥大组Km值分别下降22%和86%。

Results: HE stain showed the obvious thicken of the artery, RV/ and mPAP elevated obviously (P.05) in model group in comparison with the control group, they were also elevated obviously (P.05) in the model group compared with the treatment group. The tryptase + mast cell and the chymase + mast cell obviously increased in the model group compared with the control group, also increased in the model group compared with the treatment group.

平均肺动脉压力模型组动物较对照组明显升高(P.05)，模型组较治疗组也明显升高(P.05)；右心室／模型组较对照组明显增加(P.05)，模型组较治疗组也明显增加(P.05)，肥大细胞总数（类胰蛋白酶阳性的肥大细胞）及类糜蛋白酶阳性的肥大细胞模型组较对照组明显增多(P.05)，肥大细胞在治疗组较模型组明显减少(P.05)。

Results: Mast cells in uterus were mainly distributed in the myometrium, only a few in the endometrium. After ovum implantation ,the mast cells were comparatively less at the place of implantation. The number of mast cells of early and late pregnancy(1～5 dyas, 15～19 dyas) was apparently higher than that during middle pregnancy(P＜0. 05). Stained by alcian blue-safranin, both red and reddish blue mast cells decreased gradually in number during pregnancy, but the proportion of blue mast cells was increased. Critical electrolyte concentration of mast cells decreased as time went on.

结果：(1)肥大细胞主要分布于子宫肌层，子宫内膜较少，且胚泡植人部位的肥大细胞明显少于非植入部位；(2)妊娠早期(孕1～5d)和妊娠后期(孕15～19d)肥大细胞数显著多于妊娠中期(P＜0.05)；(3)Alcian蓝藏红组化染色后，可见妊娠过程中红色和红蓝混合色肥大细胞逐渐减少；蓝色肥大细胞所占比例逐渐增大，孕9～19d肥大细胞几乎全部为蓝色；(4)肥大细胞临界电解质浓度值随妊娠时间的推移而变小。

Results For the hypertrophies in left or right atrium or ventricle or doule atriums or ventricles, the ECG plus VCG method had a high sensibility and accuracy.For the hypertrophies in right atrium and double atriums,the only ECG method had the same sensibility with the ECG plus VCG method.For the righ ventricle, the only VCG method had the same sensibility with the ECG plus VCG method.For the specificity, the three methods almost had the same value.ECG plus VCG method combining the clinical material could improve the acuracy in the diagnosis of atrial and ventricular hypertrophies.

结果：ECG和VCG联用对左心房、右心房、左心室、右心室、双心房、双心室肥大诊断的敏感性及准确性最高，ECG单独应用及ECG和VCG联用对右心房及双心房肥大的诊断敏感性相同，VCG单独应用和ECG和VCG联用对右心室肥大的诊断敏感性相同；3种方法对心房、心室肥大诊断的特异性相近；ECG和VCG联用诊断心房、心室肥大时结合临床资料可提高准确性。

For the hypertrophies in right atrium and double atriums,the only ECG method had the same sensibility with the ECG plus VCG method.For the righ ventricle, the only VCG method had the same sensibility with the ECG plus VCG method.For the specificity, the three methods almost had the same value.ECG plus VCG method combining the clinical material could improve the acuracy in the diagnosis of atrial and ventricular hypertrophies.

结果：ECG和VCG联用对左心房、右心房、左心室、右心室、双心房、双心室肥大诊断的敏感性及准确性最高，ECG单独应用及ECG和VCG联用对右心房及双心房肥大的诊断敏感性相同，VCG单独应用和ECG和VCG联用对右心室肥大的诊断敏感性相同；3种方法对心房、心室肥大诊断的特异性相近；ECG和VCG联用诊断心房、心室肥大时结合临床资料可提高准确性。

Concludes:Three subsets of mast cell in human tissue are sorted and depurated with antibodies of specific enzyme and immunofluorescence labelling and flow cytometry. Mast cell of containing profuse secretary vacuoles could be displayed by confocal microscopy. It demonstrate that mast cell have material substructure offering for fast reaction of I type allergies of human being.

利用肥大细胞的特征性酶抗体、免疫荧光标记和流式细胞仪可将人组织中的肥大细胞分选纯化为三种亚型；以共聚焦显微镜显示肥大细胞含有丰富的分泌颗粒，它说明肥大细胞具备了为人体I型变态反应提供快速反应的物质基础。

With Death guitarist Schuldiner adopting vocal duties, the band made a major impact on the scene.

随着死亡的吉他手Schuldiner接受主唱的职务，乐队在现实中树立了重要的影响。

But he could still end up breakfasting on Swiss-government issue muesli because all six are accused of nicking around 45 million pounds they should have paid to FIFA.

不过他最后仍有可能沦为瑞士政府&议事餐桌&上的一道早餐，因为这所有六个人都被指控把本应支付给国际足联的大约4500万英镑骗了个精光。