肥厚

Cardiac hypertrophy is one of adaptive responses of the heart to a variety of pathological stimuli, including hypertension, myocardial infarction, congenital heart disease, heart valvula disease, and perturbations in sarcomeric function due to altered expression or mutations of contractile proteins. Increase in wall tension and hormonal stimuli are thought to directly activate various membrane-bound receptors and signal transduction cascade within cardiomyocytes resulting in the activation of immediate early genes and responsive genes such as c-jun, c-fos, c-myc, egr-1, ANF, BNP. Then the expression of construction proteins such as MLC-1, skeletal α-actin was unregulated.

中文题名hhlim基因的表达调节及其与心肌细胞肥大发生之间的关系副题名外文题名 hhlim gene expression regulation and its role in development of cardiomyocyte hypertrophy 论文作者郑斌导师温进坤韩梅学科专业生物化学与分子生物学研究领域\研究方向学位级别博士学位授予单位河北医科大学学位授予日期2003 论文页码总数106页关键词心肌细胞肥大基因表达心肌肥厚 hhlim基因馆藏号BSLW /2003 /R542.2 /33 心肌细胞肥大是高血压、心脏瓣膜病、急性心肌梗塞及先天性心脏病等临床常见疾病的一种并发症，是心肌细胞对多种病理刺激的一种适应性反应。

Results 25 protuberances from outside organ (spleen, n=19; aorta, n=4; left hepatic lobe, n=1 and cyst of pancreatic tail, n=1) and 92 SMTs were detected by EUS including 63 myogenic ones (esophageal, n=34; gastric, n=29), 9 etopic pancreases in stomach, 8 esophgeal cysts, 3 varices in gastric fundus, 3 gastric lymphomas, 2 gastric lipomas, 2 Menetrier ' s disorders, 1 esophageal lipoma and varix each.

结果发现外压性改变25例（其中脾脏19例，主动脉弓4例，肝左叶、胰尾囊肿各1例）；粘膜下肿瘤92例，包括肌源性肿瘤63例（食管34例、胃29例），胃异位胰腺9例，食管囊肿8例，胃底静脉瘤3例，胃淋巴瘤3例，胃脂肪瘤2例，巨大胃粘膜肥厚症2例，食管脂肪瘤、食管静脉瘤各1例。

Objective To explore the effects of diabetes mellitus on the left ventricular geometry in essential hypertension.

目的 探讨原发性高血压伴糖尿病对左室肥厚和构型的影响。

Fleshy of heart failure, cardiac muscle, atrium is vibratile wait for acquired character rhythm of the heart the attune on the expression of gene of wrong patient HCN4, can make If increases, cause rhythm of the heart wrong happening.

心力衰竭、心肌肥厚、心房颤抖等获得性心律失常患者HCN4基因的表达上调，可以使If增大，导致心律失常发生。

Here, then, lies the great art: to make a little render to success the sound of a catastrophe in order that those who profit by it may tremble from it also, to season with fear every step that is taken, to augment the curve of the transition to the point of retarding progress, to dull that aurora, to denounce and retrench the harshness of enthusiasm, to cut all angles and nails, to wad triumph, to muffle up right, to envelop the giant-people in flannel, and to put it to bed very speedily, to impose a diet on that excess of health, to put Hercules on the treatment of a convalescent, to dilute the event with the expedient, to offer to spirits thirsting for the ideal that nectar thinned out with a potion, to take one's precautions against too much success, to garnish the revolution with a shade.

因而出现了这样的伟大艺术：使胜利多少响起一点灾难的声音，以使利用胜利的人同时也为胜利发抖，每前进一步便散布一点恐怖气氛，拉长过渡工作中的弯路以使进步迟缓下来，冲淡初现的曙光，指控和遏制热情的谋划，削平尖角和利爪，用棉花捂住欢呼胜利的嘴，给人权穿上龙钟肥厚的衣服，把魁伟高大的人民裹在法兰绒里，叫他们赶快去睡觉，强迫过分健康的人忌口，教铁汉子接受初愈病人的饮食，挖空心思去做分化瓦解的工作，请那些害远大理想病的人喝些掺了甘草水的蜜酒，采取种种措施来防止过大的成功，替革命加上一个遮光罩。

Adult ---- wound does not heal, hypogeusia, the delay of menarche, male sterility, acne, pachyonychia, whitlow

成人--伤口不愈合，味觉迟钝，初潮来迟，男性不育，痤疮，指甲肥厚，甲沟炎。

Results among the 128 patients, 71.9% elder than 51-years-old, the lesions of 53.9% of patients located in the exposure sites, such as face and neck. For pathologic feature, six patterns were learned, the most frequent types were hyperkeratosis arid acanthosis. The clinical diagnosis consisted with pathologic diagnosis in 89 cases.

结果 六种类型脂溢性角化病的组织象均可见到，并以棘层肥厚型和角化过度型为主。51岁以上发病者占71.9%，头、面、颈等暴光部位发病者占53.9%，临床和病理诊断特合89例，临床误诊率30.47%。

Seeds 1 or 2 per fruit, wingless, oblong, plump; seed coat smooth, not mucilaginous when wetted; cotyledons obliquely accumbent.

种子1或2 每果，无翅，长圆形，肥厚；平滑，不黏的种皮被弄湿；子叶斜依着。

Seeds wingless, broadly ovate, plump or slightly flattened; seed coat smooth, not mucilaginous when wetted; cotyledons accumbent.

种子无翅，宽卵形，肥厚的或稍扁平；平滑，不黏的种皮被弄湿；子叶依着。

Seeds wingless, narrowly oblong, plump; seed coat smooth, not mucilaginous when wetted; cotyledons incumbent or accumbent.

种子无翅，狭长圆形，肥厚；平滑，不黏的种皮被弄湿；子叶现任的或依着。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。