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Presented with early artery enhancement and immediate wash out ,Two cases presented with wash in quickly and wash out slowly .The enhancement pattern of 36 liver metastatics cases was divided into the little blood provides group and the much blood provides group . The 5 cases of haemangioma were enhanced centripetally in portal phase and washed out after several minutes without arterial enhancement.

通过造影后的表现还可明确提示以下几个方面:(1)肿块内的坏死区;(2)在延迟相发现了肝内小转移灶,从而改变了临床治疗方案;(3)滋养动脉的显示;(4)门脉内栓子的鉴别诊断。36个转移性肝癌病灶分为少血供转移癌组和多血供转移癌组。6例肝血管瘤中5例均表现为向心性环行持续缓慢充填,另一例9mm的小血管瘤表现为完全、快速向心填充。

Hepatic sinusoid capillarization plays an important role in occurrence of portal hypertension. The fenestra of endothelial cells in hepatic sinusoid reduces and the diameter of fenestra decreases. The formation of basement membrane impaires the substance exchange between blood and hepatic cells,which results in oxygen deficiency, metabolic product accumulation and cell necrosis.

肝窦毛细血管化在硫代乙酰胺诱导的肝硬化门脉高压发生中起重要作用,肝窦内皮细胞窗孔减少并减小,内皮细胞下基底膜形成使肝细胞与外界物质交换减少,导致细胞缺氧、代谢产物聚集,肝细胞坏死,最终导致门脉高压的发生。

RESULTS: Levels of insulin, FFA, GOT and GPT in serum were significantly increased in model group; activities of T-SOD and GSH-Px in liver tissue and ISI were notably decreased, and content of lipid perhydride MDA was increased. HE staining revealed that there was hepatic cellular swelling in hepatic lobules, inequality of size of lipid droplets in periplast, nucleus on one side, narrowed sinus hepaticus and inflammatory cell infiltration in hepatic lobules and portal area.

结果: 模型组大鼠血清胰岛素、FFA、GOT和GPT水平明显升高,肝组织中T-SOD和GSH-Px活力和ISI明显下降,脂质过氧化物MDA含量显著增加, HE染色示肝小叶中大部分肝细胞肿胀,胞质中出现大小不等的脂滴空泡,以大泡性脂肪滴为主,核居边,细胞界限不清,肝窦狭窄,且存在小叶内及门管区炎症细胞浸润。

Results: MR demonstrated capsule wall and papillary solid lesions in one case with cystic and solid lesions of hepatobiliary cystadenoma. Poly cystic form tan if different sine in sew case, capsule wall and septation was thick, part of capsule wall was obviously thickened and nodes form, intrahepatic bile duct was dilated, large poly-antrum cystic keen form structure in one case, capsule wall and septation were smooth, part of capsule wall was uniformly thicken, capsule wall, septation, mural nodus form and solid lesions in three cases wee all slightly hyperintense on T2WI and slightly hypointense on T1WI. Part of cyst fluid was hypointense on T2WI the diameter if tumor ranged from 3.4cm to 13.5cm. Part of capsule wall, septation, solid lesions and mural nodus west obviously enhanced in arterial phase in three cases, the extent of enhancement showed a little degrade in port vein phase, balance phase and delay phase, but dense to liver parenchyma at synchronization.

结果:3例肝内胆管囊腺瘤中1例呈囊实性结构,可见囊壁及乳头状实性肿块;1例为多个大小不等的多房囊状结构,囊壁及分隔光滑,囊壁局部明显增厚,有壁结节,周围见轻度的肝内胆管扩张;1例为巨大的多房囊状结构,囊壁及分隔光滑,局部均匀增厚;3例中的囊壁、分隔、壁结节及实性部分均呈T2WI稍高信号、T1WI稍低信号,囊内液性部分均呈T2WI高信号、T1WI低信号;肿瘤瘤体大小径线范围3.4~13.5cm.3例肝内胆管囊腺瘤中囊壁、分隔、实性肿块和壁结节动脉期均明显强化,门脉期、平衡期及延迟期强化程度略减低,强化程度均高于同期肝实质。

The positive signal of ER and ER mRNA distributed in parenchymal and non-parenchymal hepatic cells, especially near the hepatic centrolobular and periportal areas. Ovariectomy decreased ER level and ER mRNA expression significantly (P<0.05). Hepatic ER and ER mRNA concentration were elevated after treatment with estrogen in both ovariectomy and sham ovariectomy fibrotic groups (P<0.05), and the elevation of ER was correlated with a marked decrease in hepatic damage and fibrosis.

5肝脏ERα及其mRNA基因的表达分布于肝细胞及肝脏非实质细胞,特别以肝脏中央静脉和门脉周围为主;卵巢切除减少ERα及其mRNA基因的表达(P<0.05);雌二醇治疗在肝纤维化和卵巢切除大鼠均提高肝脏ER及其mRNA基因的表达(P<0.05),其增加程度与肝脏组织学损伤、纤维化指标的降低程度以及肝脏胶原沉积减少相平行。

Results: Human stem cells were successfully transplanted into 6 fetal sheep and 5 lambs were born and lived. PCR analysis showed that there was human derived cell engraftment in the liver of the 5 lambs. Immunohistochemical staining and ISH with Alu probe showed human derived hepatocytes in the lobes or around periportal area, expressing albumin and CR18. Alu ISH also showed there were positive cells in the epithelia of bile duets.

结果:在移植的 6 只胎羊中,5 只顺利生产;PCR 检测显示 5 只实验羊肝脏组织中均有人源性细胞的嵌合:免疫组化及 Alu 探针原位杂交显示人源性细胞分布於门管区周围和肝小叶中,表达白蛋白、CK18 等肝细胞分化标志;Alu 探针阳胜细胞也分布於胆管上皮中。

prehepatic portal hypertension has specialties clinicalcharacter and shunt surgery is the best therapy.

肝前型门脉高压有其独特的临床特征,与肝硬化门脉高压在临床表现和治疗上都有许多不同,分流手术是治疗肝前型门脉高压的最佳方法。

ABSTRACT Direct intrahepatic portacaval shunt is created between the retrohepatic IVC and portal vein intrahepatically, with partial portal flow shunted directly to the IVC. DIPS can eliminate the defect that the outflow vein—hepatic vein is vulnerable to stenosis or occlusion after TIPS.

直接性门腔分流是在肝后段下腔静脉与门脉之间建立肝内分流,将部分门脉血液直接分流入粗大的下腔静脉,解决了TIPS术后分流道引流静脉——肝静脉易狭窄或闭塞的缺陷。

Objective:To explore the factors related to effects and prognosis of surgical treatment of hilar cholangiocarcinoma.

对近7年来收治的经病理诊断确诊的41例肝门部胆管癌患者的临床资料进行回顾性分析。

Inferior vena cava is the largest vein in human body , wider than the hepatic vein, so some researchers propose direct intrahepatic portacaval shunt to lead some portal blood flow directly into vena cava, hoping to obtain more stable bypass.

DIPS术是在肝内门静脉与肝后段下腔静脉之间建立肝内分流,将部分门静脉血液直接分流入粗大的下腔静脉,它扩大了介入性门腔分流的适应症,可使部分难以实施TIPS术的患者也能做介入性门腔分流,成为介入性门腔分流的新热点。

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