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The liver oval cell line WB-F344 derives from adult normal Fisher 344 malerats.It's a kind of liver infantine epithelial cells and has characteristics of liver stemcells.Many studies in vitro and in vivo imply that it has the role as precursor cells ofhepatocacinoma,which indicates its function in hepatocarcinogenesis.

肝卵圆细胞株WB-F344来自正常成年同基因Fisher344雄性大鼠,是一种肝脏幼稚上皮细胞,具有肝脏干细胞的性质,体内、外的许多研究表明,它与肝癌的发生有一定的关系,具有肝癌前体细胞的作用。

The JHU researchers prospectively examined changes in fibrosis stage between paired liver biopsies in 67 coinfected patients. Of the 67 subjects, six were excluded due to cirrhosis on the first biopsy. The median age of group was 44 years, and 75% of the subjects were men. A total of 86% had CD4+ cell counts of less than 200 cells/mm3, and the same number of subjects were receiving antiretroviral therapy. Twenty-seven percent of the patients abused alcohol. The median time between biopsies was 2.84 years (interquartile range, 2.05 - 3.41 years).

JHU研究人员前瞻性地检验67位共同感染病患成对肝脏切片的纤维化严重度变化,在67位受试者中,6位因在第1次肝脏切片时就已经是肝硬化而被排除;受试者平均年龄为44岁,而且75%的受试者为男性;86%患者的CD4+细胞计数低於200 cellsmm3,而且同样数目的受试者接受抗反转录病毒药物治疗;27位病患有酗酒的习惯;切片之间的平均时间为2.84年(四分位数中距为2.05-3.41年)。

It is illustrated that mice were treated by DHA for long time, liplyosis in adipose tissue was prometed, and lipogenesis in liver was depressed. And the ADG was decrease because of decreasing in fat accumulation.3. Mice adipocytes were treated by DHA for 24 h, proliferation of adipocytes had no difference, but the proliferation was inhibited in 48 h.

由此说明,DHA长期处理小鼠会促进脂肪组织中的脂肪分解,抑制肝脏中的脂肪合成,对肝脏中的脂肪分解可能也有促进作用,从而减少脂肪累积,小鼠平均日增重的降低,可能与DHA抑制脂肪合成并促进脂肪分解的作用有关。3。

Opuntia Milpa Alta prolonged the exhausted swimming time of mice notably, strengthened the LDH activity, accelerated the removing of the LA and BUN, strengthened the SOD activity of liver and skeletal muscle, accelerated the removing of the MDA content of liver and skeletal muscle, demonstrated positive Anti-Movement-Fatigue function. We inferred one of Anti-Movement-Fatigue mechanism was that Opuntia Milpa Alta could increase the exercise ability and load adaptive capacity of the organism and accelerate the removing of metabolites.

米邦塔仙人掌能显著延长运动组小鼠力竭游泳时间,增强运动小鼠的乳酸脱氢酶活性,加快血清乳酸和尿素氮的清除,增强运动小鼠肝脏、骨骼肌超氧化物歧化酶活性,加快肝脏、骨骼肌丙二醛的清除,显示出了积极的抗运动性疲劳作用,并推测其抗运动性疲劳的机制之一是通过增强机体运动能力和负荷适应能力,加快代谢产物的清除起作用。

The morphologic changes of the liver,heart and kidney in relation to the serum choleic acids in obstructive jaundce of rats were investigated.One of the results showed that one to two weeks after the common bile duct was ligated and servered,the damages to the damages to the mitochondria were found in the organs,while the serum choleic acids markedly increased.

对阻塞性黄疸模型鼠的心脏、肝脏和肾脏的形态学改变及其与胆汁酸血症的关系进行了研究,结果表名,胆道梗阻1~2周,心脏、肝脏和肾脏的形态学改变及其与胆汁酸血症的关系进行了研究。

Objective:To detect the rat model of non-alcohol fatty liver disease the effect of medical intervention Methods: The Wistar rats were fed with high fatty chow for 12 weeks to induce NAFLD.And then,these rats were fed the low fatty chow,and separately intervened by Rhizoma polygoni cuspidate,Polyene phosphatidylcholine and metformin hydrychloride or controlled by distill water for 4 weeks.The total RNA of adipose tissue was extracted and reversely translated into cDNA.

Non-alcohol fatty liver disease;Intervention;Rhizoma polygoni cuspidatei;Polyene phosphatidylcholine;Metformin hydrychloride非酒精性脂肪肝病(Non-alcohol fatty liver disease,NAFLD)是无过量饮酒史的肝实质细胞脂肪积贮和变性的病理综合症,是由于肝脏本身和各种肝外因素引起的肝脏脂肪代谢功能障碍,导致肝细胞内脂类物质蓄积过多的一种病理变化,常见原因有营养缺乏、肥胖、糖尿病、妊娠、糖皮质激素、肝炎及药物或毒物的损伤等[1],发病机理尚未完全清楚。

Zeta potential was -44.23 millivolt. Viscosity was 1.83 mpa. All of which were coincided with physical desire. In addition, the tests of PHGF liposomes including irritation, hemolysis, pyrogen, anomaly toxicity and hypersensibility, proved that the preparation reached the standard of intravenous injection entirely. Taking glutamic pyruvic transaminase and malondialdehyde in mice as index, studies on pharmacodynamics after hepatic injure caused by tetrachloromethane in mice indicated that GPT level (P.001) and MDA yieldment P

以小鼠CCli急性中毒性肝损伤为模型,以动物血清中谷丙转氨酶(GP水平与肝脏中丙二醛p A烨成量为指标,进行PHGF脂质体的药效学试验,结果表明P**F脂质体能显著降低GP T水平o<0刀01)与MD A 生成量厌<o.05);大鼠组织形态的观察表明高剂量***F脂质体能使肝脏 0 内皮细胞增生活跃,提高肝细胞的免疫功能,对受损肝细胞具有修复作用;同样小鼠碳廓清试验也显示PHGF脂质体较市售粉针具有更好的机体免 p 疫作用o功刀01),达到制剂设计目的,获得较好的结果。

As a supplement of conventional CT, CT perfusion imaging can reveal the perfusion informations of tissue or organs, such as hemodynamics, microcirculation status. It is helpful not only in finding morphologic changes, but also in providing functional and metabolizable information about the circulation parameters of hepatic diseases. So, it is valid for studying liver disorders by providing functional information, especial for the differential diagnosis and assessment for therapeutic response.

作为常规CT的一种补充,它能提供组织器官微循环状况、血流动力学变化等其它灌注参数,对肝脏病变除了能显示解剖形态学改变,还能了解血流动力学状态等反映功能、代谢变化的信息,在肝脏疾病的影像诊断与鉴别诊断等方面具有重要的作用,特别是对各种治疗方法的疗效评估及监测具有指导意义。

The results showed that ACP positive reactions were mainly deposited in lysosome, nucellar cell, cellular endomembrane, mitochondriurn, and endoplasmic reticulum in four tissues of the healthy shrimp. Furthermore, ACP activity was located in microvilli, and around partly lipid droplet in liver. AKP positive reactions were mainly deposited in cell membrane, nucellar cell, lysosome. endoplasmic reticulum and cellular endomembrane in four tissues.

结果显示,在健康的对虾体内,ACP依次出现在各组织中的溶酶体、细胞核、细胞内膜、线粒体、内质网以及肝脏组织中的部分脂滴周围及微绒毛中AKP依次出现在各组织中的细胞膜、细胞核、溶酶体、内质网以及肝脏组织中的脂滴周围及微绒毛中。

The faciform ligament is an important sign of laparoscopic liver surgery and a way of collateral circulation of liver. The superior liver artery found and named in this research can be an important sign to judge the position of hepatic vein. The operation pathway by cutting down the perihepatic ligament next to the superior border of liver is a quick way with little blood. It is difficult to hurt diaphragm and hepatic vein, and the secundum porta hepatic can be showed clearly. As a rule, we break the hepatic vein in the hepatic parenchyma on laparoscopic hepatectomy. But in some situation, extrahepatic treatment was used.

镰状韧带是腹腔镜肝脏外科入路的重要标志,是肝脏侧枝循环的重要途径;本文所发现并命名的肝上动脉可以作为判定肝静脉位置的重要标志;紧贴肝上缘打开肝周韧带,不易损伤膈肌和肝静脉,出血少、速度快,可以使第二肝门获得良好的手术显露;腹腔镜肝切除时一般在肝实质内切断肝静脉,在个别情况也可以预先在第二肝门结扎切断肝静脉。

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