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The activity of Ca2+-ATPase and phosphorylase A of liver in rats was determined to study the effect of acrylonitrile on calcium homeostasis and to clarify the toxicological mechanism of ACN.

本文通过丙烯腈对大鼠肝脏Ca2+-ATPase和磷酸化酶A活性影响的研究,探讨了丙烯腈对动物肝脏钙稳态的影响,进一步阐明丙烯腈的毒作用机制。

The pig's liver does whatJoey's can't.

猪的肝脏可以代替Joey的肝脏工作除去血中的有害物质

We found the UCP1 mRNA in liver of tree shrew by RT-PCR, and both the content of total RNA in liver and the expression of UCP1 were increased.

采用UCP1引物P3、P4以RT-PCR的方法在中缅树鼩肝脏中检出UCP1 mRNA的存在,并且冷驯化可使中缅树鼩肝脏总RNA的含量有所上调,使UCP1表达增加。

The results showed that hyperhomocysteinemia was induced by restraint stress. The highest CBS enzyme activity was seen in rat livers. A decrease in hepatic activities of CBS was found in restraint stress rats. The 29.4%±2.5% reduction in the activity of CBS was accompanied by a 44.1%± 3.4% decrease in its mRNA level. CBS enzyme activity was slightly elevated in the kidney of stressed rats while it was almost undeterminable in the cardiovascular system.

结果可见,束缚应激可导致大鼠高同型半胱氨酸血症的发生; CBS在肝脏具有最强的代谢活性,肾脏其次,而心脏和血液中活性极低;应激大鼠肝脏CBS活性和mRNA水平均显著降低( P 。05),应激3周时分别为对照组的70.6%±5.9%和55.9%±4.3%。

CT perfusion images can visually show different traits of Hemodynamics of hepatic Benign and Malign pathology; No matter what background, various parameters of hepatic tissue around malign lesions had significant difference with far-end liver tissue, while various parameters of hepatic tissue around benign lesions had no significant difference with far-end liver tissue; Allopatric efficiency of hepatic Malign pathology distinctly went up with hepatocirrhosis background;Various parameters of hepatic Benign and Malign pathology had no significant difference and differential significance were no significant.

灌注参数图像能直观显示肝脏良、恶性占位性病变血流动力学的不同特点;无论在何种背景下,恶性病变灶周组织与远端肝组织各同种参数间有显著差异,而良性病变灶周组织与远端肝组织各同种参数间无显著差异,以上特点可以鉴别肝脏占位性病变的良、恶性;肝硬化背景下,恶性病变的发生率明显增高;正常肝组织背景下,良、恶性占位病变组织灌注参数间无显著差异,鉴别诊断意义不大。

Hepatocellular carcinoma is the most common primary neoplasm of the liver and often arises in the context of a chronic liver disease that impairs coagulative function.

肝癌是最常见的肝脏肿瘤,并经常出现在能损伤凝血功能的慢性肝脏疾病的行列中。

GdCl3(10mg/kg) or the same volume of NS was continually injected of vein at 48h and 24h before LPS(5mg/kg) was injected in the male kunming species mouse. Then took out of liver or isolated KCs 30 minute after LPS was injected and assay the protein expression and phosphorylation level of ERK1/2 and p38MAPK of liver or KCs in vivo.Ⅱ. Isolated and cultured KCs of mouse, 1 h pretreatment with GdCl3; Culture medium with LPS(100ng/ml) was added and continuatively incubated 30 minute. Assay the protein expression and phosphorylation level of ERK1/2 and p38MAPK of KCs in vitro and detection effect of GdCl3 on its phagocytosis function in respectively.

Ⅰ 雄性昆明种小鼠在注射LPS(5mg/kg)前48h、24h,分别静脉注射GdCl3(10mg/kg )或等量的生理盐水,于LPS或生理盐水注射后30min,分别取出肝脏或分离KCs,检测肝脏或KCs ERK1/2、p38MAPK蛋白表达及磷酸化水平;Ⅱ体外培养小鼠KCs经GdCl3(100μM)预处理1h,加入含LPS(100ng/ml)的DMEM培养基继续孵育30min,分别检测体外培养KCs ERK1/2、p38MAPK蛋白表达及磷酸化水平和GdCl3对其吞噬、分泌功能的影响。

Purpose:To prove the effect of Evodia rutaecarpa on the respiratory system of mitochondria in mouse liver,the indes of these have been detected,and also the Regulatory mechanism.

目的:本试验尝试从给药组与空白组表征大鼠肝脏线粒体呼吸功能各指标变化的角度,探索吴茱萸对机体呼吸功能的调控机制,以证实吴茱萸对大鼠肝脏线粒体呼吸功能的影响。

PartⅡ:Effect of bicyclol on hepatocyte apoptosis in alcohol-intoxicated mice and related mechanismsThree consecutive intragastric administration of alcohol(6g/kg)in 12h interval resulted in an obvious liver injury and inflammation in mice,as indicated by the elevation of serum alanine transaminase(2.2 fold of control),increased hepatic COX-2 protein expression(2.2 fold of control),as well as liver pathological changes characterized by myelonic degeneration,vacuolar degeneration and inflammatory infiltration.

双环醇对酒精中毒小鼠肝脏细胞凋亡的保护作用及机制研究小鼠连续三次酒精(6g/kg)灌胃后可导致明显肝损伤,变现为血清ALT水平升高(为对照组的2.2倍),肝脏炎症相关蛋白环氧合酶-2(cyclooxygenase-2,COX-2)表达增加(为对照组的2.2倍),肝组织出现髓样变性、小空泡变性和炎性细胞浸润。

This review focuses on the current research progress of the liver cell differentiation source, and it also discusses the advantages and disadvantages of various hepatic stem cells and nonhepatic stem cells, expecting to provide a reference for liver cell source selection during tissue engineering, an adequate and suitable source for bioartificial liver and hepatocyte transplantation and to help to treat liver diseases.

本文着重论述了目前肝脏细胞的分化来源研究进展情况,并对各种肝源性和非肝源性干细胞的优缺点进行了讨论,以期为肝组织工程选择细胞来源提供参考,为生物人工肝、肝细胞移植提供充足、合适的细胞来源,协助治疗肝脏疾病。

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As she looked at Warrington's manly face, and dark, melancholy eyes, she had settled in her mind that he must have been the victim of an unhappy attachment.

每逢看到沃林顿那刚毅的脸,那乌黑、忧郁的眼睛,她便会相信,他一定作过不幸的爱情的受害者。

Maybe they'll disappear into a pothole.

也许他们将在壶穴里消失

But because of its youthful corporate culture—most people are hustled out of the door in their mid-40s—it had no one to send.

但是因为该公司年轻的企业文化——大多数员工在40来岁的时候都被请出公司——一时间没有好的人选。