肝脏的

In an effort to develop a simple method for identifying patients who may have fatty liver disease, Dr. Bedogni and colleagues used data from the Dionysos Nutrition and Liver Study to determine the degree to which drinking habits, anthropometry, and metabolic parameters contribute to the risk for the condition in 216 patients with suspected liver disease but no hepatitis B and C infection as well as in 280 age- and sex-matched controls. All participants were from the same town in northern Italy. The presence of fatty liver disease was confirmed via ultrasonography. Results were presented here by Vittorio di Maso, MD, another researcher at the Liver Research Center, at the 41st annual meeting of the European Association for the Study of the Liver.

为了发展出一个简单的方法於鉴定脂肪肝疾病病患，Bedogni 医师及其同僚使用迪奥尼修斯营养与肝脏研究的数据，对280位年龄与性别相符者之中的216位疑似有肝脏疾病但无B型或C型肝炎的病患，加以区别饮酒习惯、人体测量学、导致风险的代谢参数等，所有参与实验者都是来自义大利北部的一个城镇，藉由超音波扫瞄确定出现脂肪肝疾病；研究结果在欧洲肝脏研究学会第41届年会由前述肝脏研究中心的另一位研究员、Vittorio di Maso 医师发表。

These results indicated that the variations of taurine concentration in liver not only affacted liver steroid metabolism, but also influenced hepatic other lipid (such as glyceride and phospholipid) metabolism.

本研究结果表明，肝脏牛磺酸浓度的变化不仅影响肝脏固醇代谢，而且肝脏其它脂质的代谢也发生改变。

Methods 241 cases without liver diseases and hepatomegaly were selected.Their liver volume,the maximal and hepatic hilar cross-sectional areas in normal adult were obtained from abdominal CT examinations.

本文利用CT对正常成人肝脏大小体积进行测定，并探讨肝脏最大平面、肝门平面面积与LV的关系，旨在为临床判断肝脏大小提供更简便的方法和参考依据。

The comparisons of biochemistry between OP and OR rats The differences between OP and OR rats included not only body weight, but lipids metabolism and insulin sensitivity as well, characterized with insulin resistance, increasing in serum free fatty acids and ketone body, and hepatic TC and TG in OP rats. However, no significant differences were observed in serum TG, TC, LDL, HDL and fasting glucose between OP and OR rats.⑶Comparisons of metabolites in serum, urine and liver tissue between OP and OR rats①There were significant differences in amino acids concentration between OP and OR rats,especially in liver tissue, such as high concentrations in ketogenic and glucogenic amino acids in OP rats, suggesting differences in amino acids metabolism;② The different metabolites between OP and OR rats included increasing of various saturated fatty acids and decreasing of polyunsaturated fatty acids in OP rats;③The urinary metabolites analysis indicated that different structure or metabolism of gut microflora might exist between the two phenotypes, which probably influenced the regulation of body weight gain;④The end-products of catecholamines in urine and intermediates of krebs cycle in serum in OP rats were all up-regulated, suggesting that the activity of sympatheic nervous system and energy metabolism was higher in OP rats than OR rats.

胰岛素耐受实验和胰岛素敏感指数表明OP动物的胰岛素敏感性较OR动物下降，而OP大鼠血清中游离脂肪酸、酮体、肝脏总胆固醇和甘油三酯水平显著升高；但是，OP与OR大鼠血清中总胆固醇、甘油三酯、低密度脂蛋白、高密度脂蛋白和空腹血糖等的水平并无显著性差异；⑶肥胖易感与肥胖抵抗大鼠血清、尿液和肝脏组织提取物中代谢物的比较研究表明：①OP与OR大鼠的血清、尿液和肝组织提取物中多种氨基酸的含量存在显著差异，并以肝组织中的差异氨基酸数量为最多，包括各种生酮和生糖氨基酸水平在OP组的升高，说明氨基酸代谢的差异是两种体重表型大鼠之间存在的重要差异特征之一；②OP与OR动物肝脏和血清差异代谢物中包含多种饱和长链脂肪酸的升高如十四烷酸、十六烷酸、硬脂酸等和多不饱和脂肪酸的下降如亚油酸和花生四烯酸，说明两种体重表型动物的肝脏脂肪酸代谢存在明显差异；③长期高脂饮食喂养后，动物的尿液代谢物分析表明OP与OR动物体内的肠道菌群结构存在差异，这些菌群上的差别可能在动物体重增长的调节上产生影响；④与OR动物相比，OP动物尿液代谢物中儿茶酚胺类递质的代谢终产物如高香草酸、扁桃酸和4-羟基苯乙酸明显升高。

Here we show that senescent cells accumulate in murine livers treated to produce fibrosis, a precursor pathology to cirrhosis.

在这里我们展示在鼠类的肝脏中堆积衰老细胞用于使肝脏纤维化，肝脏纤维化是肝硬化的前驱病理改变。

The SOD and the LDH-1 activities and EST (R_f=0.17 and R_f=0.72) at 1℃weresignificantly higher than the values of the room temperature(P＜0.05), but the total enzymeactivities of LDH, G6PDH and EST at room temperature and 1℃were similar(P＞0.05).This showed well-developed anoxia tolerance of the Heilongjiang wood frog to maintainplasma viability when low temperature interrupts the delivery of oxygen and substrates. LDH-1rose significantly avoided the liver lactic acid accumulation that may created the liver to bewearied. EST (R_f=0.17 and R_f=0.72) rose may enhance the ester metabolism to offer muchenergy. These showed steady metabolic rate and relative stable organism environment of theHeilongjiang wood frog to survive under low temperature.Native PAGE separated proteins of liver tissue successfully on the better condition is 6％final gel concentration and there were 15～19 bands identified on this condition.

同功酶电泳图谱显示，1℃组与室温组黑龙江林蛙肝脏LDH酶活性差异不显著，均以LDH-5为主，但1℃组LDH-1显著高于室温组(P＜0.05)，推测黑龙江林蛙为适应低温低氧环境，增强LDH-1酶活性以较好的利用乳酸，避免因大量乳酸形成造成肝脏疲劳；而1℃组肝脏G6PDH酶活性无显著变化，进一步说明低温条件下葡萄糖戊糖途径和糖酵解作用的互相协调，维持机体代谢的稳定；1℃组和室温组EST总酶比活力无显著变化，但1℃组中R_f=0.17和R_f=0.72的EST同工酶显著升高(P＜0.05)，推测在低温条件下黑龙江林蛙可能通过选择性增强部分酯酶同功酶活性，增加肝脏酯类物质代谢，为机体提供维持生命必需的最低能量。

The apoptosis was evaluated by AQ-stained fluorescin, DNA ladder by gel electrophoresis and subdiploidy by propidium iodide-stained flow cytometry.

肝脏对血流的廓清率达1800ml/min，尤其结直肠静脉血主要经门静脉流入肝脏，因此在结直肠癌血道转移中，肝脏是最常见的靶器官。。

Results The 47 cases etiologies of various hepatic perfusion disorders were classified: arterioportal fistulae in 9 cases, inflammatory hyperemic changes in 8 cases, portal venous inflow and hepatic venous outflow obstruction in 13 cases, steal phenomenon by tumors in 4 cases, aberr...

结果47例肝脏灌注异常，有以下几种情况：肝动脉门静脉瘘9例，炎症性充血8例，门静脉、肝静脉阻塞13例，肿瘤盗血现象4例，肝脏迷走血供2例和其它原因1例。结论多层螺旋CT三期增强扫描是评价肝脏异常灌注的有效方法。

The elimination half-life t(subscript β1/2 was 161.10h, 333.21 h and 611.26h, respectively, and the total body clearance was 27.4mL/, 16.8g/ and 18.0g/, respectively. The metabolite ciprofloxacin concentration-time profiles of the plasma, muscle and liver presented similar trend. The multi- peak phenomenon were observed in the plasma, muscle and liver, but the first peak time was 24h, 24h and 12h, respectively. The peak residue of metabolite ciprofloxacin was in liver, muscle and plasma, ordinally. The eliminating rate of ciprofloxacin from muscle and liver was very low.

代谢物环丙沙星在鳗鲡血浆、肌肉和肝脏中药物水平的变化趋势与恩诺沙星基本相似，呈现出多峰现象，但3种组织中环丙沙星出现第一个药峰时间分别为给药后第24小时、24小时和12小时，3种组织中环丙沙星峰值水平肝脏中最高、肌肉中次之、血浆中最低，环丙沙星在肌肉和肝脏中的消除速率比较缓慢。

The mRNA expression of HMGR gene was detected in liver, abdominal and subcutaneous adipose tissues, intestines and muscles of Landes and Sichuan White geese, while it was highest in liver. These data suggested that cholesterol synthesis of the two gene-types geese was the same as chicken and human, and it was mainly synthesized in the liver not in adipose tissue.

朗德鹅和天府肉鹅HMGR基因在肝脏、腹脂、肠、皮脂和肌肉中都有表达，但是在肝脏中的表达量最高，表明鹅同鸡和人一样，胆固醇合成主要是在肝脏中，而不是在脂肪组织。

As she looked at Warrington's manly face, and dark, melancholy eyes, she had settled in her mind that he must have been the victim of an unhappy attachment.

每逢看到沃林顿那刚毅的脸，那乌黑、忧郁的眼睛，她便会相信，他一定作过不幸的爱情的受害者。

Maybe they'll disappear into a pothole.

也许他们将在壶穴里消失