肝脏

Objective:To detect the rat model of non-alcohol fatty liver disease the effect of medical intervention Methods: The Wistar rats were fed with high fatty chow for 12 weeks to induce NAFLD.And then,these rats were fed the low fatty chow,and separately intervened by Rhizoma polygoni cuspidate,Polyene phosphatidylcholine and metformin hydrychloride or controlled by distill water for 4 weeks.The total RNA of adipose tissue was extracted and reversely translated into cDNA.

Non-alcohol fatty liver disease；Intervention；Rhizoma polygoni cuspidatei；Polyene phosphatidylcholine；Metformin hydrychloride非酒精性脂肪肝病（Non-alcohol fatty liver disease，NAFLD）是无过量饮酒史的肝实质细胞脂肪积贮和变性的病理综合症，是由于肝脏本身和各种肝外因素引起的肝脏脂肪代谢功能障碍，导致肝细胞内脂类物质蓄积过多的一种病理变化，常见原因有营养缺乏、肥胖、糖尿病、妊娠、糖皮质激素、肝炎及药物或毒物的损伤等[1]，发病机理尚未完全清楚。

In Comlex model group the endangium plaque were widespread, while in that of High cholesterol group there was only single small plaque. The pathological heart changes of both High cholesterol group and Complex model group weren't obvious, with mild oedema and small fat drops. The liver cells of High cholesterol group showed mild oedema, while fat drops in the liver of Complex model group were more typical.

病理显示主动脉弓变化明显，复合模型组内膜斑块弥漫，而单纯高脂组内膜只出现单个小斑块，单纯高脂组和复合模型组心脏病变区别不大，均见轻度水肿和小脂肪滴；单纯模型组肝脏细胞轻度水肿，而复合模型组肝脏脂肪滴明显。

The mice inoculated with Coxiella burnetii intrana- sally developed interstitial pneumonia,while the primary pathological changes of mice inoculated intraperitoneally are granulomas in spleen and liver.2.The pathological changes became more severe followed the dosage increasing.3.Coxiella burnetii can be detected in spleen and liver at day 2 after inoculation.the lesion became more and more serious from day 2 to day 12.The characteristic changes were observed at day 7,and recovered at day 14. 4.The reticuloendothelial system are main target of Coxiella burnetii.The pathogen was detected in cytoplasm of monocyte -macrophages of spleen, liver, lung, and endothelioid cells of blood vessel. 5. Coxiella burnetii can be found in macrophages lysosomes by electron microscopy. Most of them are round or rod, and polymorphic shape can also be observed in different size.

结果：1、通过不同感染途径的实验证实，滴鼻感染的小鼠主要表现为间质性肺炎，而腹腔注射感染小鼠则以脾脏、肝脏肉芽肿为主要病变。2、通过不同剂量的感染实验发现，随着感染Q热立克次体剂量的加大，动物病变愈加严重。3、通过感染后不同时间的动态病理学观察发现，在腹腔注射后第2d的脾和肝脏即可发现病原体，主要脏器的病理变化从第2d到第12d逐渐加重，第7d动物的病变最典型，至感染后14d动物的受损器官已开始出现修复性变化。4、 Q热立克次体主要侵害机体的网状内皮系统，在感染小鼠的肝、脾、肺和外周血管单核巨噬细胞以及血管内皮细胞胞浆中查见病原体。5、透射电镜观察可见Q热立克次体主要位于巨噬细胞吞噬溶酶体内，呈多形性，多见圆形和杆状，大小不一。

Chronic EHYP can remarkably increase the activities of ERD and ANH, whose mechanism is probably related to up-regulating of CYP3A2 and CYP2E1 expression at the transcriptive level.

结论慢性间断性低氧能显著增加大鼠肝脏ERD、ANH活性，其机制可能与其在转录水平上提高肝脏CYP3A2和CYP2E1的基因表达水平有关。

Purpose:To prove the effect of Evodia rutaecarpa on the respiratory system of mitochondria in mouse liver,the indes of these have been detected,and also the Regulatory mechanism.

目的：本试验尝试从给药组与空白组表征大鼠肝脏线粒体呼吸功能各指标变化的角度，探索吴茱萸对机体呼吸功能的调控机制，以证实吴茱萸对大鼠肝脏线粒体呼吸功能的影响。

Q: As Hepatology Digest, it is a newspaper distributes in China by thousands of copies to southern Chinese hepatologist.

肝脏病学杂志是在中国华南地区主要面向肝脏病临床医生的，发行量达上万的期刊。

Hrs reperfusion following ischemia 30 min (I/R2h group) and 4 hrs reperfusion following ishcemia 30 min (I/R4h group). The changes of NF-kappa B and ICAM-1 in the forebrain cortex, hippocampine cortex and hypothalamus region measured by using immunohistochemical technique were compared among 6 groups.

应用免疫组化法分别检测各组大鼠肝脏TNF-α及脑皮质、海马和下丘脑区NF-κB、ICAM-1的表达情况，应用原位杂交的方法检测肝脏IL-1βmRNA表达情况。

Since the heart, kidney, liver and nervous system are the most commonly involved organs, amyloidosis should be considered if any clinical manifestations of hydremic nephritis, cardiac and hepatic disease, and abnormalities of the nervous system are found.

心脏、肾脏、肝脏及神经系统是淀粉样变性相对常见的累及部位，对于病因不明肾病综合征患者、任何无法解释心脏、肝脏及神经系统症状的患者都应考虑到淀粉样变性。

Zeta potential was -44.23 millivolt. Viscosity was 1.83 mpa. All of which were coincided with physical desire. In addition, the tests of PHGF liposomes including irritation, hemolysis, pyrogen, anomaly toxicity and hypersensibility, proved that the preparation reached the standard of intravenous injection entirely. Taking glutamic pyruvic transaminase and malondialdehyde in mice as index, studies on pharmacodynamics after hepatic injure caused by tetrachloromethane in mice indicated that GPT level (P.001) and MDA yieldment P

以小鼠CCli急性中毒性肝损伤为模型，以动物血清中谷丙转氨酶（GP水平与肝脏中丙二醛p A烨成量为指标，进行PHGF脂质体的药效学试验，结果表明P＊＊F脂质体能显著降低GP T水平o＜0刀01）与MD A 生成量厌＜o.05）；大鼠组织形态的观察表明高剂量＊＊＊F脂质体能使肝脏 0 内皮细胞增生活跃，提高肝细胞的免疫功能，对受损肝细胞具有修复作用；同样小鼠碳廓清试验也显示PHGF脂质体较市售粉针具有更好的机体免 p 疫作用o功刀01），达到制剂设计目的，获得较好的结果。

Percentage of dressing, eviscerated carcass decreased significantly as dietaryω6/ω3 was reduced; percentage of abdominal fat, subcutaneous fat and intermuscular fat were higher in birds fed lower ratio diets. Drip loss in both breast and thigh muscle increased significantly in birds fedω6/ω3 ratio from 18 to 2.6. Except b* value in breast muscle decreased as birds fed dietary ratio from 5 to 2.6, the tendency for breast and thigh muscle were almost similar; a* values progressively increased as the diets contained increasingω3 content, changes in b* were also significant but the pattern was almost the reverse for changes in a*. Decreasing the dietaryω6/ω3 clearly increased the contents of ALA, EPA and DPA, but not for DHA.

结果表明：①饲喂10：1的日粮显著增加6周龄AA鸡的体重和日采食量；②随着日粮ω6/ω3比值的降低，屠宰率和净膛率显著下降；低ω6/ω3比值的日粮增加腹脂率、皮下脂肪和肌间脂肪；③日粮ω6/ω3比值从18下降到2.6时，胸、腿肌滴水损失显著下降；除日粮比值从5降到2.6时胸肌b*值下降外，胸、腿肌变化规律相似，a*值和b*值变化趋势相反：a*值下降，b*值上升；④日粮ω6/ω3的降低，ω3 PUFA中ALA、EPA和DPA显著增加；⑤肝脏中ALA含量低于胸肌，而其长链衍生物C20：3、EPA和DHA的含量则是肝脏中含量较高。

With Death guitarist Schuldiner adopting vocal duties, the band made a major impact on the scene.

随着死亡的吉他手Schuldiner接受主唱的职务，乐队在现实中树立了重要的影响。

But he could still end up breakfasting on Swiss-government issue muesli because all six are accused of nicking around 45 million pounds they should have paid to FIFA.

不过他最后仍有可能沦为瑞士政府&议事餐桌&上的一道早餐，因为这所有六个人都被指控把本应支付给国际足联的大约4500万英镑骗了个精光。