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Liver function and pathological changes of hepatic tissue were examined.

采用ANIT灌胃制备大鼠急性肝内胆汁淤积病理模型,共32只大鼠,设正常组、正常+大黄素组、模型组和模型+大黄素组,观察各组实验动物肝功能各项生化指标和肝组织病理学改变,并采用实时荧光定量RT-PCR检测肝细胞膜转运蛋白基因多药耐药蛋白1a(mdr1a)、多药耐药蛋白1b(mdr1b)和多药耐药蛋白2(mdr2)mRNA水平的表达,Western blot方法检测肝脏P-糖蛋白的变化。

The effect on gastric secretion in rats was studied with pylorus ligation. The analgesic effect was tested by the hot - plate test and writhing method.

结果:舒肝丸能抑制正常小鼠胃排空及新斯的明所致的胃排空和肠推进亢进,对阿托品所致的胃排空、肠推进迟缓有协同作用,但不明显;能抑制大鼠胃酸及胃蛋白酶的分泌,促进胃粘液的分泌;可提高小鼠的热痛阈,减少小鼠的扭体次数。

Objective To study antiradiation and antifatigue effects of a soft capsule mainly composed of cistanche,acanthopanax senticosus and jujube. Methods The mice were divided into four groups and then orally given soft capsule at doses of 0 .0g/kg.bw, 0.18g/kg.bw, 0.36g/kg.bw, 1.08g/kg.bw for a successive period of 30 days.The burden-swimming time , hepatic glycogen, serum urea nitrogen, lactic dehydrogenase of mice were observed. The mice were divided into four groups and then was orally given soft capsule at doses of 0 .0g/kg.bw, 0.18g/kg.bw, 0.36g/kg.bw, 1.08g/kg.bw for a succession of 21 days.

设立3个实验组,每天分别以0.18、0.36和1.08g/kg·bw剂量的软胶囊给小鼠灌胃一次,同时设立空白对照组,连续灌胃30d后,测定小鼠的负重游泳时间、肝糖原含量、运动后血清尿素水平、血乳酸曲线下面积等指标,以测定其抗疲劳作用;每天以上述剂量给小鼠灌胃,同时设立一个辐射对照组,连续灌胃21d后,不同指标选择不同的照射剂量,各组均以同一剂量γ射线全身照射一次,照射后继续给予样品。

Operative design: After gastric anterior wall was exposed, any Crow's nerve was identified from antral surface nearby gastric angle. Along the Crow's nerve, Latarjet nerve was found, gastric branches of Latarjet were gradually severed, the dissection proceeds to up towards the diaphrageal fissula, and then, the right gastroepiploic neurovascular bundle was cut, the distal two-thirds of the greater curvature was mobilized by dividing the greater omentum, the posterior nerve of Latarjet may be seen and isolated in the same way.

手术设计:暴露胃前壁,自胃角附近的胃窦壁表面任意找到一支&鸦爪&支迷走神经,随以此支为标志向上找到分出该鸦爪的Latarjet氏神经干,顺该神经向上游离,分离中避开向右走行的肝支及胃小弯的主要血管,逐一切断走向胃壁的迷走神经分支,直游离到膈肌食管裂孔平面。

In the morning,rats in the model and the drug groups were ingested drink spirits,naming "Erguotou"(56°)(0.5ml/100 per day); In the afternoon, drugs were givenamong drug groups respectively, model group was given saline (1ml/100g per day).Meanwhile, The Model and the drug groups were given innutritious diet(40% flour+20% soybean meal+20%hypo-flour+20% botan-flour+a few soybean oil, salt),besides, those rats were prohibited to eat any food except water from 20:00 everynight to the next morning before gavage, the normal group was given saline and anormal diet.

肝纤维化模型组及药物组,上午:予56°白酒&二锅头&灌胃(每日1次,每次0.5ml/100体质量);下午:药物组予相应药物,模型组予生理盐水灌胃(每日1次,每次1ml/100体质量),且每晚八点后禁食至第二天上午空腹灌胃后再予饲料;正常对照组予等量的生理盐水做对照。

Methods:To observe the contents of total bilirubin and alanine aminotransferasein serum ,the contents of malondialdehyde , activity of superoxide dismutase , level of nitrogen monoxide in serum and liver tissue ,hepato-pathohistologic changes by CCl4,αnaphthalin fluorescein isothiocyanate inducing acute liver injury and icterus respectively in mice by po, the effects of sedum lineare thunb on the biochemical changes were analysed.

分别采用四氯化碳(CCl4)、α萘异硫氰酸酯一次性灌胃中毒致小鼠急性肝损伤及黄疸模型,测定血清谷丙转氨酶、总胆红素含量及血清、肝组织中丙二醛、超氧化物歧化酶、一氧化氮水平和观察肝组织病理变化,分析佛甲草对上述指标的影响。

Sixty six male Sprague-Dawley rats were randomly divided into control group,and 5 model hepatic fibrosis groups perfused alcoholic,maize oil and pyrazole for 2 weeks,4 weeks,8 weeks, 12 weeks and 16 weeks (11 rats in each group) respect...

结果 与对照组比较,酒精灌胃 4周、8周、12周、16周组大鼠OPN、α SMA表达显著增强并且肝内胶原纤维含量显著增加。正常肝组织中几乎不表达OPN ,在酒精性肝纤维化大鼠模型的建立过程中,从第四周开始中央静脉。。。

The liver cell cord was obvious,but there was no apparent acini hepatic and central veins,however,the hepatic sinusoid in liver was developed.

肝细胞索明显,但无明显的肝小叶,亦无明显的中央静脉存在,但肝血窦发达;胰腺主要弥散分布于肝脏中以及胃与肠交接之处,其他还伴随着肠呈纵行分布。

Methods Forty mice were randomly divided into 4 groups: one normal control group,mice in the other three groups were all infected each with 25 cercariae, the infected control group was fed for 10 weeks after infection, and 2 weeks after infection, the high dose PTX group was given PTX 360 mg/ for 8 weeks and the low dose PTX group was given PTX 180 mg/also for 8 weeks.

将40只小鼠随机分为4组,其中3组每只小鼠人工感染日本血吸虫尾蚴25条,1组感染后继续喂养10周,不作治疗,作为感染对照组;2组分别于感染后2周用PTX 360 mg/和180 mg/灌胃治疗8周;另1组不感染、也不接受药物治疗,与上述3组同步喂养10周,作为正常对照组。10周后将上述4组小鼠分别剖杀取肝组织,光镜观察肝组织病变;用免疫组化染色方法检测小鼠肝组织中Bcl-2、Bax的水平。

Hepatic portal interdicting can aggravate the gastric mucosa damage of the liver cirrhosis rat, and famotidine can protect against such gastric mucosa injury through improving the microcirculation of gastric mucosa.

肝门阻断可引起肝硬化大鼠胃粘膜损伤的加重,法莫替丁可能通过改善胃粘膜的微循环而对肝硬化大鼠胃粘膜起保护作用。

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It has been put forward that there exists single Ball point and double Ball points on the symmetrical connecting-rod curves of equilateral mechanisms.

从鲍尔点的形成原理出发,分析对称连杆曲线上鲍尔点的产生条件,提出等边机构的对称连杆曲线上有单鲍尔点和双鲍尔点。

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血精的原因很,以良性病变为主。