肝的

Laser capture microdissection is a key technique in proteomic study which can effectively resolve the problem of irrelevant tissues.

激光捕获显微切割是蛋白质组研究中的一个突破性的技术，可以有效地解决组织异质性的问题；本实验检测到的差异蛋白例如BK125H2.1可能成为鉴别肝细胞癌与肝内胆管癌特异性的分子标记物。

Result: 286 restrain the secretion of TGF-β〓 and decrease the quantity ofα-SMA in liver cells, and the accumulation of FN, LN, type Ⅰand Ⅲ collagen in ECM. The degree of liver cell damage was alleviated and the adverse effect what the purtenance received was lightened. The store function of liver was enhanced.

结果："268方"可抑制TGF-β〓的分泌，减少α-SMA在肝细胞间存在的量，减少ECM之FN、LN、Ⅰ、Ⅲ型胶原等的沉积，同时可减轻肝细胞受损程度、增强肝脏贮备功能、减轻内脏受到的不良影响，从而实现预防及治疗慢性肝炎的目标。

Result:286 restrain the secretion of TGF- P 1 and decrea se the quantity of a -SMA in liver cells ,and the accumulation of, HSJ.LN, type I and HI collagen in ECM The degree of liver cell damai ie was alleviated and the adverse effect what the purtenance received was lightened The store function of liver was enhanced The preventive and curative effect on chronic hepatitis was re ached.

结果："268方"可抑制TGF-β_1的分泌，减少α-SMA在肝细胞间存在的量，减少ECM之FN、LN、Ⅰ、Ⅲ型胶原等的沉积，同时可减轻肝细胞受第6hi共96贝成都中医药人学助：1：毕业论义作者：潘年松损程度、增强肝脏贮备功能、减轻内脏受到的不良影响，从而实现预防及治疗慢性肝炎的目标。

Connaughton (1994) and Sprague (2000) mentioned that the differences of length, weight, and tension of the sonic muscle and the amount of protein and glycogen affect the types of sounds emitted. To reveal the producer of high-frequency sound, this research analyzed and compared the length, width, thickness and somatic of sonic muscle and the amount of protein and glycogen in seven sciaenid species occuring on the west coast of Taiwan (Johnius tingi, Johnius sina, Johnius amblycephalus, Johnius amblycephalus, Pennahia argentata, Chrysochir aureus, and Otolithes ruber), then to find if the differences of physic parameter and energy supplication are the major factors making O. ruber produce high frequency of sound.

在Connaughton (1994)和Sprague (2000)研究报中指出造成石首鱼产生不同型态的声音主要取决於发声肌肌纤维的长度、重量、张力、蛋白质与肝醣含量的差异性，为了证实高频声音确实为红牙鱼或所产生，本研究将分析比较在台湾西岸海域其他不同石首鱼(红牙鱼或、黄金鳍鱼或、白姑鱼、中华叫姑鱼、皮氏叫姑鱼、丁氏叫姑鱼与顿头叫姑鱼)发声肌之长度、重量、蛋白质与肝醣含量差异，探讨发声肌在物理参数与能量的供应的差异是否为造成红牙鱼或产生高频鸣音之主要因素。

Results:①All gallstones type Ⅰ and Ⅳ in animal models were dissolved quickly, however, MTBE showed somewhat toxicity in inhibiting CNS, so that the dose of MTBE should be controlled precisely.②No abnormal change of liver and renal functions of dogs were found before and after operations.③Choloecyst pathological sections of gallbladder suggested that no evident of damage and inflammation of gallbladder was of found. Hemopexis with reversible histological change was observed in hepatic sinusoid and centeral vein short time after administation of MTBE.

结果：①动物模型的Ⅰ、Ⅳ型结石均全部迅速溶解，但MTBE有一定毒性，其对中枢神经系统有一定的抑制作用，应用时须严格掌握单位时间内的灌注剂量及总量(控制在60ml左右)；②实验犬实验前后的肝、肾功能检查无异常；③病理检查结果提示MTBE对胆囊组织无明显损伤，无严重炎性反应，给药后短期内肝窦和中央静脉有凝血现象，但其组织学变化是可逆的。

The anatomy relationship of venae hepaticae intermediae and its branches on gallbladder bed were analysed,which could be the reference during the LC.Results:For 112 patients suffered from inatrophic cholecystitis and cholecystolithiasis,whose gallbladders were decoherence directdly from ectoptygma muscular coat close to the gallbladder wall.

结果：对于术前经彩色多普勒超声波检查明确的肝中静脉直接和胆囊床相贴的非萎缩性胆囊炎胆囊结石的102例患者，采用紧靠胆囊壁的浆肌层直接进行剥离；而慢性萎缩性胆囊炎胆囊结石的24例患者，采用胆囊粘膜切除，或者直接开腹手术切除，未发生因损伤胆囊床肝中静脉而大出血。

To our knowledge, reverse phase of high performance liquid chromatography was firstly developed to analyze the metabolites of 7-tocopherol with ideal results. Meanwhile, Gas chromatography/Mass chromatography were used to analyze the structures of unknown metabolites of 7-tocopherol and a main unknown metabolite was identified as a side chain ω- hydroxylate of 7-tocopherol.The kinetic results of of 7-tocopherol reacted in the S9 of male SD-rat liver showed that the optimal time was 45 min; the optimal concentration of S9 5 mg/ml; the optimal concentration of NADPH 1 mM; and the optimal concentration of 7-tocopherol 8 μg/ml. The result of γ-tocopherol metabolized in the S9 of male SD-rat was the best; male Brazil turtle better; and male cobia worst.

本试验首次确立了γ-生育酚代谢物的RP-HPLC分析方法，结果理想且重现性好；用GC／MS对γ-生育酚的未知代谢物结构进行分析，判断其中一种主要的代谢物为γ-生育酚侧链初级羟基化代谢物；γ-生育酚在雄性SD-大鼠肝S9的代谢动力学表明，本实验条件下代谢反应的最佳时间为45min，S9浓度为5mg／ml，NADPH浓度为1mM，γ-生育酚浓度为8μg／ml；发现γ-生育酚在雄性SD-大鼠肝S9中代谢最高，雄性巴西龟次之，雄性军曹鱼最低。

Lienal empty is wet as a result tired model the F-ERG of AMD is changed relatively liver kidney deficit AMD is remarkable, oozy model the F-ERG change of AMD is more atrophic model lienal empty of AMD remarkable; is wet strand model those who reach P-VEP of liver kidney deficit patient to all have different rate is unusual, but unusual rate and card of doctor of traditional Chinese medicine have nothing to do; is treated through card of differentiate of doctor of traditional Chinese medicine, of patient F-ERG bright get used to amplitude to rise somewhat, the amplitude of P-VEP rises somewhat, conceal is shortened from time to tome.

结果脾虚湿困型AMD的F-ERG改变较肝肾亏损型AMD显著，渗出型AMD的F-ERG改变较萎缩型AMD显著；脾虚湿困型及肝肾亏损型患者P-VEP均有不同程度的异常，但异常率和中医证型无关；经过中医辨证治疗，患者F-ERG的明适应振幅有所提高，P-VEP的振幅有所提高，潜伏时有所缩短。

High-fat feeding of both strains led to decreased serum triglycerides, hepatic steatosis, and hypercholesterolemia; howeer, B6 mice deeloped worse steatosis and a larger increase in LDL cholesterol. Both B6 background and high-fat feeding increased sterol regulatory element-binding protein-1c (SREBP-1c), a key regulator of lipogenic gene transcription, and its downstream targets.

两种品系的高脂喂养都导致血清甘油三酯降低，脂肪肝，和高胆固醇血症；然而，B6小鼠产生更严重的脂肪肝和低密度脂蛋白胆固醇的增加。B6遗传背景和高脂喂养都增加甾醇调解元件结合蛋白-1c（SREBP-1c），它是脂肪生成基因转录和它的下游靶点的关键调解元件。

Chronicity maybe result from many factors with complex mechanism.HCV may evade the host immune surveillance due to the hypermutation of HCV gene; HCV has the nature of pantropic,the tissues outside liver can provide virus for repeatedly infection of liver; The HCV receptors,such as CD81,LDL receptor,scavenger receptor B type I,L-SIGN,DC-SIGN and so on,may influence organism humoral immunity and the cellular immunity function in different degrees; HCV infection also may cause the reduction of quantity of organism immune cell or functional defect,low response of humoral immune response,tolerance of cellular immunity,then,the host finally transforms into chronic infection condition.

其慢性化的机制非常复杂，是由多个因素造成的，HCV因其基因高变性可以逃避宿主的免疫监视；HCV具有泛嗜性，肝外组织又可为肝组织的反复感染提供病毒来源；CD81、LDL受体、清道夫受体B类Ⅰ型及L-SIGN、DC-SIGN等HCV受体又可不同程度地影响机体的体液免疫和细胞免疫功能；HCV感染亦可直接导致机体免疫细胞数量减少或功能缺陷，体液免疫应答水平低下、细胞免疫耐受，宿主最终转变为慢性感染状态。

As she looked at Warrington's manly face, and dark, melancholy eyes, she had settled in her mind that he must have been the victim of an unhappy attachment.

每逢看到沃林顿那刚毅的脸，那乌黑、忧郁的眼睛，她便会相信，他一定作过不幸的爱情的受害者。

Maybe they'll disappear into a pothole.

也许他们将在壶穴里消失