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We employed HPLC to measure the metabolites of caffeine in the whole blood and calculated the ratio be between the metabolite and caffeine, which was used as index to evaluate the effect of Qingkailing injection on rat CYP1A2 activity in vivo ; We also detected the CYP1A2 and CYP2D6 activity in microsomal reconstituted system by analysis of phenacetin metabolism and dextromethorphan metabolism with HPLC.

通过HPLC法测定全血中咖啡因的代谢率，观测清开灵注射液对大鼠CYP1A2活性的影响；通过HPLC法测定大鼠肝微粒体重组系统非那西丁的代谢比率，确定清开灵注射液对大鼠肝微粒体CYP1A2亚型的作用；测定大鼠肝微粒体重组系统右美沙芬的代谢比率，确定清开灵注射液对大鼠肝微粒体CYP2D6亚型的作用。

The results showed that either of the extracted propolis had significant inhibitory effect on the level of triglyceride, total cholesterol, LDL-C,GPT and GOT in serum, and TC, TG and MDA in liver, but were ineffective on HDL-C, MDA, SOD and NO levels in serum. Ethanol extracted propolis also reduced the body weight, liver weight and liver index of hyperlipidemic SD rats, while water extracted propolis were adiaphorous.

结果表明：蜂胶醇提液和水提液均能有效抑制高脂血症SD大鼠血清中的甘油三酯、总胆固醇、低密度脂蛋白、谷丙转氨酶、谷草转氨酶的升高，并且能有效抑制肝脏组织中的TC、TG、MDA的升高，但对血清中的高密度脂蛋白、超氧化物歧化酶、丙二醛、一氧化氮的影响不明显；蜂胶醇提液能有效降低高脂血症SD大鼠的体重、肝重及肝指数，蜂胶水提液对体重、肝重及肝指数的影响则不显著。

As antioxidants, the vitamin E or quercetin (10μg/mL) significantly attenuated the toxic effects of PCBs on the cultured hepatocytes. The above results indicated that vitamin E or quercetin might antagonize the toxic effect of PCBs via antioxidizing effects on in vitro cultured chicken embryo hepatocytes.

结果表明离体培养的鸡胚肝细胞可作为肝损伤的细胞模型，PCB对培养的肝细胞的损伤及抗氧化剂维生素E和槲皮素对它的缓解作用提示， PCB对肝细胞的损伤可能是通过诱导细胞膜发生脂质过氧化而导致细胞的死亡。

On the Mechanism of Populating d~3∏ State of NaK by LIF Method;2. We apply the technology of LIFto diagnose hepatic fibrosis which is induced by different matter.

本文应用激光诱导荧光的方法，对不同物质诱发白鼠的肝纤维化的肝组织进行了荧光光谱分析，发现经过注射不同物质的白鼠的肝组织与正常白鼠的肝组织的荧光光谱有明显不同。

The activity of glutamate-pyruvate transaminase andglutamic oxalacetic transaminase was measured using AU5400 automaticbiochemical analyzer; the activity of the hyaluronic acid,the laminin,precollagen typeⅢ type, collagen typeⅣ was evaluated according toradioimmunoassay method; the activity of transforming growth factor beta-1(TGFβ1)and tissue inhibitor of matrix metalloproteinase-1 (TIMP-1) was measured according to enzyme linked immunosorbent assay. Results First, the effect of Baoganning on CCL_4 induced hepatic fibrosis in rats.

研究结果一、保肝宁对四氯化碳(carbon tetrachloride CCL_4)复合因素致大鼠肝纤维化模型的作用： 1、与正常组动物血清相比，模型组动物血清中的ALT、AST、HA、LN、PCⅢ、CⅣ、TGFβ1、TIMP-1显著升高(P＜0.05)；与模型组相比，保肝宁高、中、低剂量组血清中的ALT、AST、HA、LN、PCⅢ、CⅣ、TGFβ1、TIMP-1显著降低(P＜0.05)；秋水仙碱组、复方鳖甲软肝组动物血清中上述指标呈不同程度的下降趋势。

4The Masson trichrome stain can be used for an important method for the observation of the fibrostic cells, The changes of the mast cell could be considered as an assist marker for the observation of the liver fibrogenesis.In addition the concentration of the hepatic hydroxyproline could be used for diagnosis of the hepatic fibrosis. clinical and experimental study.

Masson三色染色可以作为肝纤维化肝硬化组织细胞观察的一种重要方法：肝纤维化过程中，肥大细胞数量的动态变化，可以作为观察肝纤维化变化的一项辅助指标；肝脏羟脯氨酸的浓度变化可以作为肝纤维化的辅助诊断及应用于相关实验的研究。

Following that the living environment was being deteriorated day and day and the living level was being continuously raised,fatty liver and symptom of fibred liver that menace the health of human beings gradually become the common diseases. These diseases have some complicated characteristics.

随着生活环境的日益恶化和生活水平的不断提高，脂肪肝和肝纤维化等症逐渐成为威胁人类健康的常见疾病，其病程长，不易治愈等特点，使得寻找预防和治疗脂肪肝及肝纤维化的有效药物，一直是国内外研究的热点。

Results: Bax immunoreactivity was detected in 44 out of 72 cases of cholangiocarcinoma and 8 out of 25 cases of normal control, in which bile ducts among lobules in normal parts aside of hepatocellular carcinoma tissues were observed.

结果：在72例CHC中，Bax阳性44例（61.1％）；用于对照的25例肝细胞肝癌的癌旁肝组织汇管区胆管上皮Bax阳性8例（32％）。bax在CHC中的表达强于正常对照组（P＜0.01），在其中53例高、中分化的CHC的表达强于在19例低分化CHC的表达（P＜0.01），在肝内胆管癌与肝外胆管癌的表达无显著差异（P＜0.05）。

The morphologic al changes of the livers were examined under light microscope and electron m icroscope.

结果保存0～120h的兔肝，其组织结构基本正常；保存到144h兔肝，电镜下见肝细胞的线粒体出现轻度肿胀和嵴少；随着保存时间的延长肝细胞出现明显的细胞变性。

Sodium propionate and sodium pyruvate could promote liver gluconeogenesis by up-regulating the abundance of PEPCK-C mRNA in the hepatocytes, but the up-regulation was limited.

表明，丙酸钠、丙酮酸钠能通过上调体外培养的新生犊牛肝细胞PEPCK-C mRNA的表达而促进肝糖异生代谢，但上调作用是有限的；胰岛素能通过下调体外培养的新生犊牛肝细胞PEPCK-C mRNA的表达而抑制肝糖异生代谢，且下调作用呈剂量依赖性；胰高血糖素与胰岛素作用刚好相反；瘦蛋白未起直接的调节作用。

In the United States, chronic alcoholism and hepatitis C are the most common ones.

在美国，慢性酒精中毒，肝炎是最常见的。

If you have any questions, you can contact me anytime.

如果有任何问题，你可以随时联系我。