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Results 20 cases of CT examination had made proper diagnoses,the CT imaging finding about the most of peripheral cholangiocarcinoma included:There was the atactic low density tumour in liver,its borderline was unclear,enhanced scan appearances were irregular peripheral enhancement,centripetal enhancement,and delaying enhancement;There was concretion and dilatation of bile buct in or around the focus;The local envelope of liver was lacunose and the local liver was atrophied,There was abroad putrescence and liquescence in the focus.

结果 20例CT做出了正确的诊断,大部分周围型胆管细胞癌的CT表现为肝内不规则低密度肿块边界欠清,增强扫描表现病灶边缘呈不规则环状强化,有向心性强化的趋势,出现延迟强化;病灶内或周围可见结石,病灶内及周围肝内胆管扩张;局部肝包膜回缩、肝叶萎缩,病灶内大片坏死、液化。

The selective deposition of agrin in hepatocellular carcinoma microvessels versus sinusoidal walls prompted us to investigate the utility of agrin immunohistochemistry in detecting malignant hepatocellular lesions.

Agrin选择性地沉积在肝细胞肝癌的微血管而非肝窦壁,此特点就促使我们研究应用agrin免疫组化来诊断肝细胞恶性病变的效用问题,着重于肝细胞腺癌和异型性结节,因为这两者的鉴别诊断常常很困难。

Results: The light microscope pictures of group A(no [α-32P] ATP in the perfusate) showed that there was no specially labeled silver pellet in or out of rat liver cell. But the light microscope pictures of group B (37 MBq [α- 32P]ATP in the perfusate) showed that distribution of numerous [α-32P]ATP autoradiographic silver pellets in rat liver cell, and no autoradiographic silver pellet was found in the hepatic sinus and vessel.

结果:灌流液中不加[α-32P]ATP的A组光镜照片显示大鼠肝细胞内外均未见特异性标记银粒显影,而灌流液中含37 MBq[α-32P]ATP的B组光镜照片显示大鼠肝细胞内可见多个大小不等的[α-32P]ATP自显影银粒分布,而肝窦及肝小叶中央静脉等血管内则几乎无黑色自显影银粒分布。

Hepatic artery infusion chemotherapy is used primarily in patients with inoperable primary or metastatic hepatic tumors. During HAIC system implantation, the guide wire used to support the insertion of the catheter can damage the gastroepiploic artery resulting in intraperitoneal bleeding when percutaneous catheter placement and tip fixation method was used.

肝动脉化疗经常是用在无法开刀的原发性或转移性恶性肝肿瘤的治疗方法,而在肝动脉化疗导管暨注射基座系统植入时经常将导线置於胃大网膜动脉来做为支撑导管置入的路径,所以在肝动脉化疗导管暨注射基座系统植入过程中胃大网膜动脉可能会受到损害而有可能导致腹内之出血。

Results 20 cases of CT examination had made proper diagnoses,the CT imaging finding about the most of peripheral cholangiocarcinoma included:There was the atactic low density tumour in liver,its borderline was unclear,enhanced scan appearances were irregular peripheral enhancement,centripetal enhancement,and delaying enhancement;There was concretion and dilatation of bile buct in or around the focus;The local envelope of liver was lacunose and the local liver was atrophied,There was abroad putrescence and liquescence in the focus.

结果 20例CT做出了正确的诊断,部分周围型胆管细胞癌的CT表现肝内不规则低密度肿块边界欠清,增强扫描表现病灶边缘呈不规则环状强化,有向心性强化的趋势,出现延迟强化;病灶内或周围可见结石,病灶内及周围肝内胆管扩张;局部肝包膜回缩、肝叶萎缩,病灶内大片坏死、液化。

Methods The expression of caspase-3 and PCNA was detected by tissue microarray and immunohistochemical method in 95 hepatocellular carcinoma tissues,68 parahepatic cancer tissues and 19 normal liver tissues.

目的 探讨Caspase-3和PCNA在肝细胞肝癌的表达及其在肝细胞肝癌发生、发展中的作用方法应用组织芯片技术和免疫组化方法检测95例肝细胞肝癌组织、68例癌旁组织和19例正常肝组织中Caspase-3和PCNA的表达。

In conclusion, the hepatotoxicity of clivorine is caused by the hepatotoxic pyrrolic metabolites formed in vivo. CYP3A involved in the formation of pyrrolic metabolites and plays a key role in metabolism-induced hepatotoxicity of clivorine.

Clivorine的肝毒性是其在体内形成的肝毒性吡咯代谢物所致,CYP3A参与了肝毒性吡咯代谢物的形成并在clivorine的代谢致毒方面发挥了关键性的作用,因此CYP3A的诱导剂和抑制剂可以影响肝毒性吡咯代谢物的形成,从而影响clivorine的肝毒性。

The second was study on hepatocellular apoptosis during hepatic cold preservation-reperfusion. The third was investigation on effects of rewarm ischemia on the structure and function of reperfusing donor livers as well as its relevant mechanism.

实验分三个部分:离体供肝缺血-再灌注损伤模型的建立;供肝低温保存-再灌注期间肝细胞凋亡的研究;供肝复温缺血对再灌注后供肝功能的影响及相关机理。

Histological observation showed that normal structure was observed in all the groups before being harvested or after being preserved for 30 minutes. However, the more severe structure damage was observed in HPCs or hepatic sinusoidal cells with the more prolonged rewarm ischemia.

形态学观察发现,四组供肝于离体前及低温保存30分钟时的组织结构均无明显异常改变;而在复温缺血期间,各组供肝肝实质细胞及肝窦内皮细胞则表现有不同程度的结构损伤,且在程度上也与复温缺血时间呈明显的平行关系。

Experimental Center of National Level One, Hubei Traditional Chinese Medica l College, Wuhan 430061)Abstract To investigate the protective effects of Jiaweisinisa n on acute liver injury induced by intraperitoneal injection of D-ga lac-tosamise, serum superoxide dismutase, malondialdehyde , glutathioe contents were measured. The pathological changes of liver wer e observed simultaneously. The results showed that JWSNS could decrease serum MD A content, but increase serum SOD and GSH activities in acute liver injury induc ed by D-GalN. It was also found that JWSNS could alleviate the degeneration and necrosis of the hypatocytes.

为研讨加味四逆散防治肝损伤的作用机理,通过动物试验,先用加味四逆散预防给药,再采用D-氨基半乳糖造成大鼠急性肝损伤模型,然后检测大鼠血清超氧化物岐化酶、丙二醛、还原型谷胱甘肽水平,同步观察该方对急性肝损伤大鼠体内脂质过氧化反应及肝脏病理改变的影响,结果表明该方可明显升高大鼠血清SOD、GSH水平,降低MDA水平,肝脏病理学检查亦表明该方使肝细胞变性坏死程度减轻。

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