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These results suggest that levetiracetam is an effective and well-tolerated adjunctive treatment for patients with previously uncontrolled idiopathic generalized epilepsy with myoclonic seizures.

本研究显示左乙拉西坦对于患有特发性全身性癫痫伴肌阵挛性发作未控制的病人是一种有效而又可以耐受良好的辅助治疗。

Background: Currently, there are no published randomized controlled trials evaluating the efficacy and safety of adjunctive antiepileptic therapy in idiopathic generalized epilepsy with myoclonic seizures.

研究背景:最近没有评价辅助抗癫痫疗法对于特发性全身性癫痫伴肌阵挛性发作的效果和安全性的随机对照研究的文章发表。

Methods: This randomized, double-blind, placebo-controlled multicenter trial assessed the efficacy and tolerability of adjunctive treatment with levetiracetam 3,000 mg/day in adolescents (12 years) and adults (65 years) with idiopathic generalized epilepsy, who experienced myoclonic seizures on 8 days during a prospective 8-week baseline period, despite antiepileptic monotherapy.

本研究采用随机、双盲、安慰剂对照的多中心研究方式,评价在患有特发性全身性癫痫,虽抗癫痫治疗,仍在治疗后的8星期基线期内有8天为肌阵挛性发作的青少年(12岁)和成年(65岁)中使用左乙拉西坦3000mg/天作为辅助治疗的效果和耐受性。

Disorders using International League Against Epilepsy classifications, such as Lennox-Gastaut syndrome, benign childhood epilepsy with centrotemporal spikes, childhood absence epilepsy and juvenile myoclonic epilepsy are increasingly being recognised in Hong Kong.

根据国际抗癫痫联盟的分类命名,诸如 Lennox-Gastaut 综合徵、伴中央颞区棘波的儿童期良性癫痫、儿童失神癫痫及青少年肌阵挛性癫痫等病在香港正逐渐被认识。

Results the map and hr were significantly decreased in group b. except for myoclonus observed in group a,there were no side effects in both groups.

结果 b组map和hr显著下降,除a组中观察到肌阵挛外,两组中未见明显不良反应。

Tremors, myoclonus, cranial-nerve palsies, and movement disorders also occur, although seizures are unusual.

震颤、肌阵挛、颅神经麻痹以及运动紊乱也可发生,但癫痫样发作不常见。

Affected individuals may present with sleep disturbances, personality changes, ATAXIA; APHASIA, visual loss, weakness, muscle atrophy, MYOCLONUS, progressive dementia, and death within one year of disease onset.

受感染的人可以有睡眠紊乱,个性改变,共济失调,失语症,视觉丧失,物理,肌肉萎缩,肌阵挛,进行性痴呆等症状,并且会在发病的一年内死亡。

In patient with acute onset of visual disorders, the differential diagnosis of a Heidenhain variant of CJD must be taken into consideration. The disease of having rapidly progressive dementia and myoclonus could be differentiated from occipital infarction.

遇有老年人迅速发生视力障碍者应想到有本病的可能,迅速进展的痴呆和肌阵挛发作可以与枕叶梗死相鉴别。

Results The initial and prominent symptoms include depression, insomnia, headache, dizziness, memory impairment and gait ataxia. The most common symptoms include progressive dementia and myoclonus.

结果 CJD患者以进行性痴呆和肌阵挛最常见,首发症状多为抑郁、失眠、头痛、头晕、记忆力减退及行走不稳。

Primary brain stem tumours were located mainly in the pons (91.7%).The multiple cranial nerve palsies, cerebellar ataxia, motor and sensory disturbanceswere the dominant objective findings.

临床特征除多数颅神经麻痹、锥体束和脑干小脑联系纤维功能障碍外,尚有括约肌障碍、不自主发笑和肌阵挛发作等。

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