肌酸

The effects of different denaturants on CK and salt-induced molten globule state were studied. The results showed that arginine and aspartate caused inactivation and unfolding of CK.

在研究不同变性剂对肌酸激酶结构和活性的影响及盐诱导的熔球态时发现精氨酸和天门冬氨酸引起肌酸激酶失活和去折叠，为一级反应的一相过程。

Results These two patients were confirmed to suffer from DMD. They were characterized by typical features of DMD including typical clinical manifestations, increased serum enzymes, EMG presenting myogenic impairment, HE staining presentation belonging to DMD, negative dystrophin in brother, and inconstantly positive on the sarcolemma of sister. Furthermore, no deletion or duplication was found in the 1-79 exons of dystrophin gene. The suffering brother and sister carried the same maternal X chromosome.

结果 兄妹二人符合DMD诊断，具有典型的DMD临床表现，肌酸激酶、肌酸激酶同工酶、乳酸脱氢酶、羟丁酸脱氢酶和谷草转氨酶的水平均显著高于正常值，肌电图呈肌源性损害，肌肉HE染色符合DMD，男患者的抗肌萎缩蛋白表达阴性，女患者的少量肌纤维仍可见不连续膜阳性，两患者抗肌萎缩蛋白基因的1~79号外显子未见缺失和重复突变，女患者与男患者携带相同的母源性X染色体。

From the femur bone density analysis of protein expression, we can see that light chain lactoferrin, annexin decreased and the expression of enolase, ATP synthase, acetyl-coenzyme A reductase, the expression of troponin, may be related to ovariectomized femoral bone density in osteoporosis-related happened; strong bone of the femoral osteoporosis Po intervention effect may be related to reduced enolase, ATP synthase, troponin, CK-MB, acetyl phosphoglycerate enzyme, the expression of myosin, and the increase in lactoferrin light chain, pyruvate kinase isoenzyme, protein expression crown.

从股骨密质骨蛋白质组表达分析可知，乳铁蛋白轻链、膜联蛋白A3的表达下降及烯醇化酶、ATP合酶、乙酰辅酶A还原酶、肌钙蛋白的表达增强，可能与去卵巢后股骨密质骨骨质疏松的发生相关；强骨宝对股骨骨质疏松的干预效应可能与下调烯醇化酶、ATP合酶、肌钙蛋白、肌酸激酶同工酶、磷酸甘油酸变味酶、肌球蛋白的表达，和上调乳铁蛋白轻链、丙酮酸激酶同工酶、冠蛋白的表达有关。

This means that glucose transport capacity was not a key determinant for glycogen accumulation under normal diet and the training situation; Ingestion of creatine or glutamine for 2 weeks prior glycogen depletion exercise exert no rule in glucose transport, GN gene expression, GS activity, and muscle glycogen resynthesis rate and amount during recovery from depletion exercise, but the interactions between endurance training and glutamine, high-intensity intermittent training and creatine, and endurance training and high-intensity intermittent training, were all capable of increasing muscle glycogen resynthesis significantly.

说明正常饮食训练情况下，肌肉葡萄糖转运能力不是决定肌糖原储量的关键因素；耗竭运动前补充肌酸或谷氨酰胺，对运动后恢复过程中的肌肉葡萄糖转运、GN基因表达和GS活性无明显影响，对运动后肌糖原再合成的速率和量也无显著效应，但耐力训练与谷氨酰胺、间歇高强度训练与肌酸以及耐力训练与间歇高强度训练的交互作用可使肌糖原合成量显著增加。

In our study, we also observed the different influence between TTB-USA and RFCA on blood coagulable states (by examining the change ofα-granule membrane protein、Tissue type plasminogen activatior、Plasmingen activator inhibitor-1)、 endothelium function (by examining the change of endothelin、nitric oxide) and myocardial injury (by examining the change of creatine kinase、MB isoenzy of creatine kinase and cardiac troponin T).

为观察超声消融与射频消融对血凝状态、内皮功能及心肌损伤的影响，进一步对超声消融的安全性进行评价，我们在插管前、插管后、消融后即刻、消融后30min及48小时5次抽静脉血，分别测定血小板α-颗粒糖蛋白(GMP-140)阳性表达活化血小板百分率、内皮素、一氧化氮、组织型纤溶酶原激活剂及纤溶酶原激活剂抑制物-1(PAI-1)的变化；于消融前、消融后即刻、2hr、8hr、24hr、48hr、72hr抽取静脉血，检测肌酸激酶、肌酸激酶MB同工酶及心肌肌钙蛋白T的变化。

METHED We selected 40 patients underwent coronary angiography. Blood samples for measurement of CRP, Cardiac Troponin I, Creatine Kinase, MB isoenzyme of CK and lipoidemia were taken in the morning just before angiography in all patients. Each subject was sought details of sex, age. Body Mass Index, history of smoking, hypertension, diabetes mellitus.

方法选取住院并接受冠状动脉造影(coronary angiography， CAG)的患者40名进入本研究，均于CAG前采集空腹血，检验C反应蛋白、肌钙蛋白Ⅰ(Troponin Ⅰ，TnⅠ)、甘油三酯、总胆固醇、高密度脂蛋白胆固醇、肌酸激酶、肌酸激酶同工酶MB，并收集所有患者年龄、年龄、高血压史、糖尿病史、吸烟史、体重指数的资料。

Finally confirmed that,The thighbone and the osteoporosis morbidity is possibly connected protein 6, respectively are: The lactoferrin light chain, membrane association protein A3, the enolase, ATP gather the enzyme, the acetyl coenzyme A reductases, the myo calcium protein; The lumbar vertebra and the osteoporosis morbidity is possibly connected protein 5, respectively are: The actin, the keratin, the enolase, ATP gather the enzyme, the myosin; The thighbone and the strong bone valuable curative effect is possibly connected protein 9, respectively are: The enolase, ATP gather the enzyme, the myo-calcium protein, the creatine activating enzyme isozyme, the phosphoglyceric acid change flavor the enzyme, the myosin, the lactoferrin light chain, the pyruvic acid activating enzyme isozyme, the crown protein; The lumbar vertebra and the strong bone valuable curative effect are possibly connected protein 8, respectively are: The carbonic anhydrase, the actin, the αB-crystal protein, 3-phospho-glycerol aldehyde oxidase, the serum albumin, ATP gather the enzyme, the myosin, the enolase.

最后确认：股骨与骨质疏松发病可能相关的蛋白6个，分别为：乳铁蛋白轻链、膜联蛋白A3、烯醇化酶、ATP合酶、乙酰辅酶A还原酶、肌钙蛋白；腰椎与骨质疏松发病可能相关的蛋白5个，分别为：肌动蛋白、角蛋白、烯醇化酶、ATP合酶、肌球蛋白；股骨与强骨宝疗效可能相关的蛋白9个，分别为：烯醇化酶、ATP合酶、肌钙蛋白、肌酸激酶同工酶、磷酸甘油酸变味酶、肌球蛋白、乳铁蛋白轻链、丙酮酸激酶同工酶、冠蛋白；腰椎与强骨宝疗效可能相关的蛋白8个，分别为：碳酸酐酶、肌动蛋白、αB-晶体蛋白、3-磷酸甘油醛脱氢酶、血清白蛋白、ATP合酶、肌球蛋白、烯醇化酶。

Non-DAI group also showed decreased NAA/Cr at splenium and increased Cho/Cr at genu of corpus callosum compared with control group (P 0.01), but the change degree was less than DAI group.

与对照组相比，非弥漫性轴索损伤组出现胼胝体膝部胆碱复合物/肌酸和磷酸肌酸升高和压部N-乙酰天冬氨酸/肌酸和磷酸肌酸降低(P 0.01)，但变化程度比弥漫性轴索损伤组低。

The chaperone activity of porcine kidney peptidyl-prolyl cis-trans isomerase was studied. The results showed that inactive or active PPIase was able to improve the refolding yields of creatine kinase , and inhibited aggregation. However, alkylated PPIase was not able to prevent CK aggregation.

研究猪肾脯氨酰顺反异构酶的伴侣功能时发现有活性和无活性PPIase能够提高肌酸激酶再折叠产量，抑制肌酸激酶聚沉，但是烷基化PPIase丧失防止肌酸激酶聚沉的能力。

Producing Creatin monohydrate, Ctreatine anhydrous, Taurine, Tri-Craetine citrate, Tricreatine Malate, Creatine Ethyl ester Glycocyamine, Guanidino propionic acid, etc.

生产一水肌酸，无水肌酸，肌酸乙酯，牛磺酸，三肌酸苹果酸，三肌酸柠檬酸，胍基乙酸，胍基丙酸，肌氨酸钠，面粉增白剂等食品添加剂等。

The concept of equivalent rotationally rigidity is offered and the formula of rotationally rigidity is obtained.

主要做了如下几个方面的工作：对伸臂位于顶部的单层框架—筒体模型进行分析，提出了等效转动约束的概念和转动约束刚度的表达式。

Male cats normally do not need aftercare with the exception of the night after the anesthetic.

男猫通常不需要善后除了晚上的麻醉。