肌酐

Above organs emerged different damage in crude middle and high dose and processed high dose after 3 months and serum indicators- creatinine, urea nitrogen manifestly were increased, the coefficients of liver, kidney and gaster manifestly were heightened.

连续给药3个月，生品的中、高剂量组和炮制品的大剂量组均出现了上述脏器程度不同的损伤，可见血清生化指标的肌酐、尿素氮明显升高，肝、肾、胃脏器系数明显增加。

Laboratory evaluation consists of hematocrit (hemoconcentration suggests preeclampsia), platelet count, protein excretion, serum creatinine, serum uric acid, serum alanine and aspartate aminotransferase concentrations, and lactic acid dehydrogenase concentration.

实验室评估包括红细胞压积，血小板计数，蛋白排泄，血肌酐，血尿酸，血清丙氨酸氨基转化酶和天门冬氨酸氨基转化酶，和乳酸脱氢酶浓度

Results Compared with low-salt diet control group, the renal changes in CsA-L group were not obvious at the 2nd weeks, the urine volume and the level of BUN were remarkably increased in CsA-H group. At the 4th weeks, the urine volume was decreased; the levels of Crea and BUN were significantly increased and showed a significant positive correlation with the blood CsA concentration. Morphologic changes consisted of vacuolization of renal tubular cells, hyalinization of small arterioles and the light renal interstitial fibrosis.

结果 与低盐对照组相比，药后第2周CsA-L组各指标无明显变化，CsA-H组尿量增多，尿蛋白降低，尿素氮升高；药后第4周时，尿量呈减少趋势，肌酐和BUN明显升高，且与CsA血药浓度呈显著正相关，病理表现为肾小管细胞空泡变性及小动脉和肾间质病变，CsA-H组各种变化较CsA-L组更为明显。

Results CsA clearly decreased creatinine clearance and increased urinary excretion of N-acetyl-β-D-glucosaminidase in rats as compared with those in the vehicle group. Morphologic changes consisted of vacuolization of tubular cell, expansion of the interstitium and interstitial fibrosis, hyalinization of afferent arterioles. Severity of the injury was related to the dosage of CsA. Striped interstitial fibrosis and arteriolopathy were more severe in the rats treated with CsA and low-salt diet than with CsA and normal diet.

结果 用CsA的大鼠出现尿量增多、内生肌酐清除率下降、尿N-乙酰-β-D-氨基葡萄糖苷酶排泄增多等；病理上表现为不同程度的细胞浊肿、空泡变性及灶性分布的间质纤维化和小动脉病变，随CsA剂量的增加，病变呈加重趋势；结合低钠饮食，CsA慢性肾毒性病变明显加重。

Methods 36 cases of UE with sustaining hemodialysis between March 2008 and June 2009 was retrospectively analyzed,20 of which received hemoperfusion online continuous venovenous hemofiltrationand 16 only underwent continuous venovenous hemofiltration.Heartrates,mean arterypressure,APACHEII score,kalium ion,hydrocarbonic radical,blood urea nitrogenand serum creawere detected before and aftertherapy.

回顾性分析我院2008年3月至2009年6月维持性透析合并尿毒症脑病的患者36例，其中20例行血液灌流串联连续性静脉-静脉血液滤过，16例行单纯连续性静脉-静脉血液滤过，比较两组治疗前后心率、平均动脉压、APACHEⅡ评分、钾离子、碳酸氢根、尿素氮、血肌酐变化以及神经精神症状缓解情况和到达缓解所需时间。

Hematocrit and blood viscosity at shear rate in 150/s, 30/s, 5/s, 1/s, renal fibrosis serum markers, serum creatinine and blood urea nitrogen were detected respectively in sham operation and model group; microcirculation microscope was used to observe the thread of hypoglottis and auricle in rats.

建立单侧输尿管梗阻致大鼠肾间质纤维化模型，观察肾间质纤维化大鼠全血粘度150/s切变率、30/s切变率、5/s切变率、1/s切变率、红细胞压积、舌下及耳廓的脉络变化，同时检测肾纤维化指标、血清肌酐及尿素氮。

All patients with lupus nephritis, who were treated in yancheng first people's hospital from Jan. 2004 to Jun. 2005, were included in this study. They all presented with macrographic hematuria.

2004年1月至2005年6月间在盐城市第一人民医院肾脏科住院的狼疮性肾炎患者，所有患者均有明显血尿、尿蛋白＞2.0 g/d，肾功能异常，血肌酐278.39±80.73/μmol。

Overloaded rat models were established by using abdominal aorta constriction method. The levels of creatinine and urea nitrogen in the rats?? serum as well as those of malonaldehyde and glutathion of the rats?? nephric tissue were measured respectively.

采用腹主动脉缩窄法制备压力超负荷大鼠模型，分别测定大鼠血清肌酐和尿素氮含量及大鼠肾组织匀浆丙二醛、谷胱甘肽含量。

The mouse was carried out half nephric duct ligation to induce the renal interstitial fibrosis animal model,afterwards,to set up three groups,control group,sham operation group(intragastric administration with normal sodium according to 10ml/kg weight),treatment group...

采用小鼠单侧输尿管结扎法诱导肾间质纤维化的动物模型，用盐酸青藤碱治疗，并设对照组、假手术组(小鼠每日按10m l/kg体重用生理盐水灌胃，直至治疗结束)、治疗组(选用正清风痛宁缓释片按每日30mg/kg体重给小鼠灌胃，连续3周，)，检测血尿素氮、血肌酐、血清层粘连蛋白、纤维连接蛋白的含量，免疫组化法测肾脏组织转化因子β1(TNF-β1)的表达并进行肾脏病理学的观察。

The nephridial tissue of all the rats was taken for pathological examinations.

选用健康雄性SD(Sprague-Dawley)大鼠，腹腔注射8 mL/kg的DEG，于注射前和注射后第2天、5天、7天以及14天尾静脉采血检测血肌酐、尿素氮和CO2结合率(CO2CP)，收集死亡大鼠及第7天和14天处死大鼠的肾组织进行病理检查。

Do you know, i need you to come back

你知道吗，我需要你回来

Yang yinshu、Wang xiangsheng、Li decang,The first discovery of haemaphysalis conicinna.

1〕 杨银书，王祥生，李德昌。安徽省首次发现嗜群血蜱。