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Before the experiment and in the second,fourth week of the experiment,blood was taken from mice's epicanthic intravenous of each group to determine biochemistry index of SCr,BUN,blood potassium,blood sodium and radioimmunity index of PCⅢ,HA,LA.

在实验前及实验的第2、4周,分别从各组大鼠眼内眦静脉采血,测定血肌酐、血尿素氮、血钾、血钠等生化指标以及Ⅲ型前胶原、血清透明质酸、层粘连蛋白等放免指标,42d时从心脏直接采血复查上述各指标,而后处死动物取肾脏进行组织形态学及特殊染色检查。

The solid-phase microextraction technique was evaluated for the determination of furoic acid and creatinine in urine. For furoic acid, the alkaline hydrolysis step was first performed to hydrolyze the furoic acid-glycine conjugate to free furoic acid.

本研究利用固相微萃取(solid-phase microextraction, SPME)动与气相层析质谱仪之结合,建立尿中呋喃甲酸与肌酸酊的分析技术,以提供评估呋喃甲醛暴露之生物侦测工具。

The results show that the hyperthyroidism group has elevated levels of choline, glucose and declined levels of VLDL, LDL, cholesterol, lactate, glycoprotein and alanine in serum samples relative to the healthy group. In urine samples, the hyperthyroidism group show increased levels of glucose, citrate, taurine and creatinine as well as decreased levels of hippurate, trimethylamine-N-oxide, formate and succinate.

结果表明,甲亢组血清中的胆碱、葡萄糖和三甲胺等物质的含量升高,而VLDL,LDL和胆固醇等脂质以及乳酸、糖蛋白和丙氨酸等代谢物的含量下降;甲亢组尿液中的葡萄糖、柠檬酸、牛磺酸以及肌氨酸等代谢物的含量升高,而马尿酸、TMAO、甲酸和琥珀酸等代谢物的含量下降。

Results Compared with low-salt diet control group, the renal changes in CsA-L group were not obvious at the 2nd weeks, the urine volume and the level of BUN were remarkably increased in CsA-H group. At the 4th weeks, the urine volume was decreased; the levels of Crea and BUN were significantly increased and showed a significant positive correlation with the blood CsA concentration. Morphologic changes consisted of vacuolization of renal tubular cells, hyalinization of small arterioles and the light renal interstitial fibrosis.

结果 与低盐对照组相比,药后第2周CsA-L组各指标无明显变化,CsA-H组尿量增多,尿蛋白降低,尿素氮升高;药后第4周时,尿量呈减少趋势,肌酐和BUN明显升高,且与CsA血药浓度呈显著正相关,病理表现为肾小管细胞空泡变性及小动脉和肾间质病变,CsA-H组各种变化较CsA-L组更为明显。

Results CsA clearly decreased creatinine clearance and increased urinary excretion of N-acetyl-β-D-glucosaminidase in rats as compared with those in the vehicle group. Morphologic changes consisted of vacuolization of tubular cell, expansion of the interstitium and interstitial fibrosis, hyalinization of afferent arterioles. Severity of the injury was related to the dosage of CsA. Striped interstitial fibrosis and arteriolopathy were more severe in the rats treated with CsA and low-salt diet than with CsA and normal diet.

结果 用CsA的大鼠出现尿量增多、内生肌酐清除率下降、尿N-乙酰-β-D-氨基葡萄糖苷酶排泄增多等;病理上表现为不同程度的细胞浊肿、空泡变性及灶性分布的间质纤维化和小动脉病变,随CsA剂量的增加,病变呈加重趋势;结合低钠饮食,CsA慢性肾毒性病变明显加重。

Results The intramural capillary lymphatics of rat's rectum were observed in deep lamina propria of tunica membrane and the dermal papilla layer of anal pectin. The intramural capillary lymphatics and lymphatics were both observed in tela submucosa, reticular layer, hypodermis and intermuscular and serosa. The capillary lymphatics in rectums' wall have the similar ultrastructure feature to normal ones. Three kinds of endothelial cells junctions are overlapping junctions, embedding-junctions and end to-end-type junctions. About 21% of cell-junctions are opening types. There are normal organelles and many vesicals in the endothelial of capillary lymphatics.

结果 直肠壁内的毛细淋巴管见於黏膜固有层深部和肛梳区真皮乳头层;在黏膜下层和肛梳区的网状层、皮下组织以及肌层和浆膜层内均有毛细淋巴管和淋巴管,直肠壁内毛细淋巴管的超微结构具有一般毛细淋巴管超微结构的特点,内皮细胞连接有重叠、嵌插和端端连接3种类型,处於开放状态约占21%;胞质内含有一般的细胞器,幷含有大量的囊泡。

Reduces Wrinkles in 61%, reduces cellulite in 38%, face looks visibly younger within a few weeks, improves skin elasticity, tightness, thickness in 68%, smoothness in 71%, rehydration of skin increases turgor, reverses sun damage and liver/aging spots, veins become less prominent,"a knifeless facelift" by regenerating the protein matrix and musculature under the skin, reduces puffiness under eyes,"turns the prune of old age back to a plum"

61%的人皱纹减少,38%的人脂肪减少,68%的人几个星期内脸部明显年轻,皮肤弹性气密性,厚实度有所改善,71%的人皮肤更为平滑,补液皮肤使之膨胀,改善晒伤和肝/老化斑点,静脉变得不那么突出,通过蛋白质基质和肌下皮肤的重生得到&不开刀的拉皮手术&之效,眼袋减少,&老梅还嫩花&

Reduces Wrinkles in 61%, reduces cellulite in 38%, face looks visibly younger within a few weeks, improves skin elasticity, tightness, thickness in 68%, smoothness in 71%, rehydration of skin increases turgor, reverses sun damage and liver/aging spots, veins become less prominent,"a knifeless facelift" by regenerating the protein matrix and musculature under the skin, reduces puffiness under eyes,"turns the prune of old age back to a plum"

61%的人皱纹减少,38%的人脂肪减少,68%的人几个星期内脸部明显年轻,皮肤弹性气密性,厚实度有所改善,71%的人皮肤更为平滑,皮肤液体液使之膨胀,改善晒伤和肝/老化斑点,静脉变得不那么突出,通过蛋白质基质和肌下皮肤的重生得到&不开刀的拉皮手术&之效,眼袋减少,&老梅还嫩花&

BACKGROUND: Under different induction conditions, bone marrow mesenchymal stem cells can differentiate into the mesodermal tissues such as osteoblasts, chondroblasts, muscle cells, adipocytes and so on.

背景:骨髓间充质干细胞在不同诱导条件下具有向中胚层组织细胞如成骨细胞、成软骨细胞、肌细胞、脂肪细胞等分化的能力。

MSCs derived from fetal liver can be induced into skeletal musclelike cells in vitro.

胎肝中分离出的间质干细胞在体外可以定向诱导分化为肌样细胞。

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