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In Series Ⅲ,about the inhibitory effect of carnosine of lipid peroxidation.

系列Ⅲ研究了肌肽抑制脂质氧化的性质。

Meanwhile, as a putative neurotransmitter in the brain, carnosine has a protective effect in many diseases such as AD, because of its abundant functions such as an anti-oxidant, in anti-glycation, anti-aging.

同时,有研究表明肌肽作为脑内一种重要的神经递质,对多种神经系统疾病如AD具有保护作用。

Bone marrow containing hematopoietic stem cells has already been known , theses another group stem cells exists in bone marrow named mesenchymal stem cells. MSCs retain the potentiality of differentiating into osteoblast, chondroblast, adipoblast, tendonblast, myoblast, cardiomyoblast, neuron, etc , which displays a bright prosperity of its use in tissue enigeering, wound healing , cell transplatation and gene therapy. MSCs can be obtained and expanded easily compared to ESC without any problems of morality , law and ethic , immunology.

最早在130年前,德国病理学家Cohnheim在研究创口愈合时就推测在创口愈合过程中出现的部分细胞可能来自骨髓。20世纪70年代,Friendenstein发现一小部分骨髓中贴壁最牢固的细胞经数此传代后形成独特的纺锤形外观,具有形成成骨细胞或软骨细胞的能力。80年代以来,许多研究小组进一步证实了Friendenstein分离到的这些细胞是多能的,在体外特定诱导条件下,可以分化为成骨细胞、软骨细胞、脂肪细胞、成肌细胞、神经元等,被称为骨髓间充质干细胞(Bone MarrowMesenchymal Stem Cells,MSCs)。

To study the expression of matrix metalloproteinase-2 (MMP-2) in human ciliary muscle cells after administration of travoprost.

研究曲伏前列腺素作用下,基质金属蛋白酶-2(MMP-2)在人睫状肌细胞的表达。

Methods: The clinical data of 41 patints with rare ectopic pregnancy including interstitial pregnancy.23 cornual uterogestation,9 ovarian pregnancy,4 abdominal,2 pregnancy were retrospectively analyzed,deformity uterogestation,1 intramural pregnancy,1 and nub of fallopian tube pregnancy,were retrospectively analyzed.

回顾 分析 2003年7月至2005年10月经腹腔镜手术治疗的特殊部位异位妊娠41例的临床资料,包括输卵管间质部妊娠23例,宫角妊娠9例,卵巢妊娠4例,腹腔妊娠2例,残角子宫妊娠1例,子宫肌壁间妊娠1例,输卵管残端妊娠1例。

N IND sections, the picture of dysplasia neurons can be distinguished from the normal easily with a smaller cell and cytoblast diameter, a distinct increase of number, less and stain thickened cytoplasm, nucleolus exit or not.

ND病变肠段粘膜下及肌间均有巨神经丛,丛内各成分细胞均呈阳性反应,神经丛内有大量大小不等细胞,为胶质细胞与发育不良神经元,其中可见部分细胞胞体较大。

Results In dioestrous mice, many iNOS+ cells were found in the stroma of endometrium. There was no obvious differences between the immunized mice and the control mice. In the uterus on 3 day of pregnancy, however, there was obvious difference about the iNOS quantity in uterus between the immunized and the control mice. There was strong positive reaction on the epithelia of endometrium and the endometrial gland in the lamina propria in control mice, while the staining of iNOS in the uterus of SA-30 immunized mice was very weak, only a few of iNOS+ cells were observed in the myometrium.

结果 SA-30免疫后对间情期小鼠子宫内的iNOS没有明显影响,无论是免疫组还是对照组,在子宫内膜基质中均有大量阳性细胞分布,两者无明显差异;在妊娠第3d时,对照组的小鼠子宫中有较多iNOS表达,阳性标记主要集中在内膜上皮及固有膜中的子宫腺上,经SA-30免疫的小鼠子宫中,iNOS表达则显著减少,整个内膜标记极弱,只在子宫肌层内有少量iNOS阳性细胞分布。

Results In dioestrous mice, many iNOS+ cells were found in the stroma of endometrium. There was no obvious differences between the immunized mice and the control mice. In the uterus on 3 day of pregnancy, however, there was obvious difference about the iNOS quantity in uterus between the immunized and the control mice. There was strong positive reaction on the epithelia of endometrium and the endometrial gland in the lamina propria in control mice, while the staining of iNOS in the uterus of SA-30 immunized mice was very weak, only a few of iNOS+ cells were observed in the myometrium.

结果 SA-30免疫后对间情期小鼠子宫内的iNOS没有明显瘙痒影响,无论是免疫组还是对照组,在子宫内膜基质中均有大量阳性偏瘫细胞分布,两者无明显瘙痒差异;在妊娠第3d时,对照组的小鼠子宫中有较多iNOS表达,阳性标记主要集中在内膜上皮及固有膜中的子宫腺上,经SA-30免疫的小鼠子宫中,iNOS表达则显著减少,整个内膜标记极弱,只在子宫肌层内有少量iNOS阳性偏瘫细胞分布。

In this context, we have reported recently that the volume of myocardial tissue occupied by perimysial and endomysial collagen was lower in hypertensive patients with HF and depressed ejection fraction, than in hypertensive patients with HF and preserved ejection fraction and normotensive subjects.56 Of interest, the interstitial and perivascular accumulation of collagen fibres was abnormally high in the two groups of patients.

在这种情况下,我们已经说了占用体积perimysial心肌组织人肌内膜胶原水平低的高血压患者用高频和沮丧的射血分数在高血压患者的心力衰竭和保存被罚出场分数与正常血压subjects.56舒张压的利息、间质和血管堆积过高的胶原纤维是在两组病人。

A clear cause-and-effect relationship between excessive myocardial MMP-1 activity, increased mysial collagen degradation, and progression to systolic HF has been shown experimentally through the use of transgenic models and the use of pharmacological MMP activators.53,54 In addition, experimental evidence has been provided showing that following chronic neurohormonal activation, increased synthesis and release of MMPs into the local extracellular matrix of the cardiomyocyte occurs,55 which in turn could contribute to endomysial and perimysial collagen degradation and disruption.

一个明显的因果过多的心肌MMP-1关系活动, mysial增加胶原蛋白的降解和进展收缩性心力衰竭已被证明试验,通过使用转基因模型和使用的MMP药理作用此外,activators.53,54实验证据下面被提供显示慢性神经激活时,增加的MMPs合成和释放到当地的细胞外基质的心肌细胞发生,55反过来有助于人肌内膜和 perimysial胶原退化和破坏。

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