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Results: All rats in experiment group devloped CAG at the end of 12 weeks with the following Pathological changes of CAG such as thin mucosa layer, thick muscle layer, decreased glandes, soakaging inflammation cells in microscope and with the time prolonging, the atrophy of gastric mucosa became more serious; In normal control group and normal feeding group, the IL-6 and IL-8 content in blood serum are the same at every time point; In experiment group, IL-6 became increased from 4wk and kept high level from 4wk to l2wk and had significant difference compared with normal controls.

结果:灌胃至12wk时出现胃粘膜层变薄,固有层腺体减少,固有层纤维结缔组织增生,粘膜肌层明显增生,慢性炎细胞浸润等萎缩性胃炎表现,随著热盐水灌胃时间的延长,32wk胃粘膜萎缩程度明显加重;正常对照组和正常餵养组大鼠各时间点血清IL-6,IL-8含量基本相同。

Myotonic dystrophy is usually obvious on clinical grounds with grip myotonia, distal weakness and wasting and the characteristic facial appearance, and was not considered likely here.

在临床见到的明显的营养不良性肌强直常表现为紧握的肌强直,远端无力和萎缩,以及特征性面容。因而在这位患者并不考虑本病。

During the past few years, several hospitals employed the mycelium of Ganoderma capens Teng obtained by submerged fermentation by our Institute for the treatment of progressive muscular dystrophy, atrophlic myotonia and certain other related dtseases whih encouraging results.

近年来,我所和有关医院协作,试用深层发酵培养的薄盖灵芝菌丝体治疗进行性肌营养不良和萎缩性肌强直等疾病,发现有一定的疗效。

The ELISA titre was 1:2000.By cell fusion, 46 hybridoma cell lines were screened,and 10 lines were cloned with limited dilution method.16 lines secreting anti-bFGF monoclonal antibody were been developed, and 2 lines targeted fusion protein. Sensitive ELISA and dot-ELISA for bFGF was developed with this mAb. The detection limit of them were 0.1 ng/well and 0.5 ng/well. The expression level of anti-bFGF mAb by different rebuilt engineering cells were identified by western blot and to direct rebuild recombiment engineering cell. The dose and character of anti-bFGF mAb inhibiting bFGF biology activity were searched by 3T3 cell line. Searching 20 tissue of liver cancer, liver cancer cell lines and general tissue of liver, finding bFGF were highly expressed in tissues of liver cancer and liver cancer cell lines. Affinity chromatography purifying bFGF was set up by mAb binging CNBr-pepharose 4B, and the purification was 95%. We found that the titer of anti-bFGF antibody was very high in serum of neuropathic amyotrophia.

应用细胞融合制备46株杂交瘤,对其中10株进行克隆化,获得bFGF特异单抗16株,2株针对融合蛋白;应用该单抗建立了0.1ng/孔灵敏度的ELISA,0.5ng/孔敏度的斑点ELISA;用Western-blotting鉴别了经改造不同工程菌蛋白表达,指导重组工程菌改造;用3T3细胞培养研究了单抗抑制bFGF生物学活性的剂量和特点;合作研究了20例肝癌、肝癌细胞株和正常肝组织,发现前者bFGF高表达;应用单抗偶联CNBr-sepharose 4B建立了小量免疫亲和层析纯化bFGF,纯度达到95%;发现神经性肌萎缩患者血清中含有高滴度的bFGF抗体,已有10多家单位引用单抗或进行合作。

The patient was a 66-year-old male who presented with paraparesis. On examination, strength was 5/5 in both upper extremities and 3-4/5 in both lower extremities. Pricking sensation was relatively retarded below the sixth thoracic vertebra on both sides. Fine-touch sensation was limited below the ninth thoracic vertebra on the right side and below the eleventh thoracic vertebra on the left side. Responses to vibration and joint position sense were well preserved. Deep tendon reflexes were increased in his legs. He had voluntary anal contraction and preserved anal and bulbocavernous reflexes. MRI revealed dissection of the descending aorta from T4 to T10 levels with thrombus present in the false lumen, and the thoracic cord was marked atrophy, especially from T6 to T8 levels. To the best of our knowledge, no such case had been reported so far.

这是一位66岁的男性病患,到院时以下半身轻截瘫来表现,检查后发现其双上肢肌力为5/5而双下肢肌力则为3-4/5,刺痛觉在两侧第六胸椎以下异常,轻触觉在右侧第九胸椎与左侧第十一胸椎以下异常,震动觉与本体感觉则皆属正常,深肌腱反射在两下肢均有异常增强的情形,肛门的主动收缩正常且肛门反射与球体海绵体肌反射均正常,核磁共振影像显示降主动脉在T4到T10处有剥离的情形并於伪腔内发现血栓,此外,病患之胸部脊髓则有明显萎缩的现象,以T6到T8处最为明显,就目前可见的文献资料,并无类似的报告被提出。

The anatomy relationship of venae hepaticae intermediae and its branches on gallbladder bed were analysed,which could be the reference during the LC.Results:For 112 patients suffered from inatrophic cholecystitis and cholecystolithiasis,whose gallbladders were decoherence directdly from ectoptygma muscular coat close to the gallbladder wall.

结果:对于术前经彩色多普勒超声波检查明确的肝中静脉直接和胆囊床相贴的非萎缩性胆囊炎胆囊结石的102例患者,采用紧靠胆囊壁的浆肌层直接进行剥离;而慢性萎缩性胆囊炎胆囊结石的24例患者,采用胆囊粘膜切除,或者直接开腹手术切除,未发生因损伤胆囊床肝中静脉而大出血。

Some simulating actions of the volleyball player were studied on the cadavers. The cause of onset of the infraspinatus atrophy in volleyball athletes were analysed and discussed. Injury of the supra...

根据解剖学资料和在尸体上的摹拟观察,分析讨论了排球运动员冈下肌萎缩症的原因,认为肩胛上神经在冈盂切述处受绞勒性损伤的可能性最大,并提出了手术治疗的意见。

This pilot study recruits cases for MUAPs analysis which include normal subjects and representative pathological subjects of progressive muscular dystrophy, polymyositis, and progressive spinal muscular atrophy, one for each case.

本研究在运动单元动作电位分析中,实验对象里有正常人也有明显呈现病徵的患者,包括了渐进性肌肉萎缩、多发性肌炎及渐进性脊髓肌肉萎缩等各一位的患者。

This resulted in dystrophin production in this muscle and no serious side-effects were observed.

在这第一期的临床实验中研究者发现了被注射的肌肉组织中有抗肌萎缩蛋白的产生,同时没有观察到严重的副作用。

RESULTS: Muscular atrophy was observed 2 weeks after denervation. The motor unit waveshape of gastrocnemius became single; time limit became long; voltage became low, and the fibrillation potential norientation wave was increased. Differences were observed between two groups 4 weeks and 8 weeks, but no differences were observed after 12 weeks.

结果:①切断坐骨神经后2周大鼠腓肠肌均发生不同程度的萎缩「左侧腓肠肌运动单位电位波形逐渐变单一,时限逐渐延长,电压逐渐变小,纤颤电位的正向波逐渐增多。4、8周时实验组与对照组有差异,12周时两组无差异。

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