肌萎缩

Objective To investigate the clinical and electrophysiology features of infantile spinal muscular atrophy, and explore the clinical significance of genetic diagnosis.

目的 探讨婴儿型脊髓性肌萎缩症的临床、电生理特点及基因诊断的临床意义。

Results All these infants were characterized by progressive flaccid paralysis in limbs.

结果 婴儿型脊髓性肌萎缩症的主要临床特征为出生后进行性加重的四肢弛缓性瘫痪。

Oct. 27, 2004 — The Entristar gastrostomy tube system is beneficial for patients with amyotrophic lateral sclerosis, according to the results of a retrospective study published in the November issue of Radiology .

Oct。 27， 2004 --一项刊载於11月份放射线医学期刊上的回顾性研究指出，Entristar胃造口术管系统，对肌萎缩脊髓侧索硬化症患者会有助益。

It demonstrated that atrophy of masseter muscle altered the craniofacial growth and development.

实验结果证实咬肌萎缩后，确实会影响颅颜骨型态及生长发育。

Objective To study the sensitivity and specificity of gene mutational analysis.

目的 本文对脊肌萎缩症基因诊断的敏感性与特异性进行了研究。

At the same time, PDI can act as molecular chaperone that help the denatured proteins refold and inhibit the aggregation of the denatured proteins.

在神经变性疾病如帕金森症、阿尔兹海默症、肌萎缩侧索硬化症、多聚谷氨酰胺疾病中，PDI可通过抑制错误折叠蛋白的聚集以及遍在蛋白化，起到神经保护作用。

And on the basis of these work, anti-bFGF Fab phage library was constructed with PMBC of autoimmune patients, such neuropathic amyotrophia patient, and two clones with very high affinity were obtained. There were 15 papers published, one paper had been incepted.

在前期研究基础上，利用神经性肌萎缩等患者血清中含有高滴度抗bFGF抗体特点，构建人源bFGF Fab噬菌体抗体库，获得2株具有较高亲和力

Objective: To explore the correct position nursing, which can promote the rehabilitation of the patients of cerebral apoplexy by accelerating the recovery of limbs function, preventing bedsore, hypostatic pneumonia, avoiding the occurrence of spastic mode, secondary articular contracture deformity and amyotrophia.

A+VB2N L 摘要：目的：探讨正确的体位护理，促进脑卒中患者的肢体功能恢复，防止褥疮、坠积性肺炎、预防痉挛模式的出现及继发性关节挛缩、畸形及肌萎缩，促进患者的康复。

Objective: To explore the correct position nursing, which can promote the rehabilitation of the patients of cerebral apoplexy by accelerating the recovery of limbs function, preventing bedsore, hypostatic pneumonia, avoiding the occurrence of spastic mode, secondary articular contracture deformity and amyotrophia.

目的：探讨正确的体位护理，促进脑卒中患者的肢体功能恢复，防止褥疮、坠积性肺炎、有奖征文121_1征稿预防痉挛模式的出现及继发性关节挛缩、畸形及肌萎缩，促进患者的有奖征文121_1征稿康复。

The ELISA titre was 1:2000.By cell fusion, 46 hybridoma cell lines were screened,and 10 lines were cloned with limited dilution method.16 lines secreting anti-bFGF monoclonal antibody were been developed, and 2 lines targeted fusion protein. Sensitive ELISA and dot-ELISA for bFGF was developed with this mAb. The detection limit of them were 0.1 ng/well and 0.5 ng/well. The expression level of anti-bFGF mAb by different rebuilt engineering cells were identified by western blot and to direct rebuild recombiment engineering cell. The dose and character of anti-bFGF mAb inhibiting bFGF biology activity were searched by 3T3 cell line. Searching 20 tissue of liver cancer, liver cancer cell lines and general tissue of liver, finding bFGF were highly expressed in tissues of liver cancer and liver cancer cell lines. Affinity chromatography purifying bFGF was set up by mAb binging CNBr-pepharose 4B, and the purification was 95%. We found that the titer of anti-bFGF antibody was very high in serum of neuropathic amyotrophia.

应用细胞融合制备46株杂交瘤，对其中10株进行克隆化，获得bFGF特异单抗16株，2株针对融合蛋白；应用该单抗建立了0.1ng/孔灵敏度的ELISA，0.5ng/孔敏度的斑点ELISA；用Western-blotting鉴别了经改造不同工程菌蛋白表达，指导重组工程菌改造；用3T3细胞培养研究了单抗抑制bFGF生物学活性的剂量和特点；合作研究了20例肝癌、肝癌细胞株和正常肝组织，发现前者bFGF高表达；应用单抗偶联CNBr-sepharose 4B建立了小量免疫亲和层析纯化bFGF，纯度达到95%；发现神经性肌萎缩患者血清中含有高滴度的bFGF抗体，已有10多家单位引用单抗或进行合作。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。