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肌萎缩

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MRI characters mainly were that amyotrophy attenuated muscle and muscle outline collapsed;intramuscular adipose heterogeneitily infiltrated,which resulted in MRI signal heterogeneitily raising up and the ratio of lumbar subcutaneous fat MRI signal to lumbar dorsal muscle MRI signal descending;intramuscular spatia was revealed as line-lamellar form or featheriness or grid grid form.

主要MRI表现包括:肌肉萎缩造成肌肉变细、形态萎缩、轮廓萎陷;肌内不均匀性脂肪浸润,造成信号不均性增高,皮下脂肪信号与肌肉信号比值下降,肌内间隙呈线片状、羽毛状或网格状。

Results: All rats in experiment group devloped CAG at the end of 12 weeks with the following Pathological changes of CAG such as thin mucosa layer, thick muscle layer, decreased glandes, soakaging inflammation cells in microscope and with the time prolonging, the atrophy of gastric mucosa became more serious; In normal control group and normal feeding group, the IL-6 and IL-8 content in blood serum are the same at every time point; In experiment group, IL-6 became increased from 4wk and kept high level from 4wk to l2wk and had significant difference compared with normal controls.

结果:灌胃至12wk时出现胃粘膜层变薄,固有层腺体减少,固有层纤维结缔组织增生,粘膜肌层明显增生,慢性炎细胞浸润等萎缩性胃炎表现,随著热盐水灌胃时间的延长,32wk胃粘膜萎缩程度明显加重;正常对照组和正常餵养组大鼠各时间点血清IL-6,IL-8含量基本相同。

Results Compared with control group,the level of serum testosterone in medol group was increased obviously(P.01),the expressions of TGF-β1 in the endometrium and myometrium were decreased significantly(P.01), the expression of TGF-βRⅠ in myometrium was decreased obviously(P.05),while the expression of TGF-βRⅠin endometrium was increased significantly(P.05). In model group ,myometrium of the uterus was tenuis,endometrium was atrophic and the number of glandular organs was decreased.

结果:与正常组比较,ASR模型组大鼠血清T水平明显增高(P.01;子宫内膜、肌层TGF-β1表达量明显降低(P.01);肌层TGF-βRⅠ表达量明显降低(P.05),而内膜TGF-βRⅠ表达量却明显升高(P.05);与正常组比较,ASR模型组大鼠子宫肌层变薄,内膜萎缩,腺体减少。

BACKGROUND: Duchenne muscular dystrophy is a cureless disease, it is a severe result of progressive atrophy of muscle cells, which caused by various defects.

背景:杜氏型肌营养不良的肌细胞损伤并非单一细胞受损,而是多因素缺陷导致肌细胞进行性萎缩的严重后果,患儿一经确诊即被告之无法医治。

Fund Project:Tackle Key Program of Liaoning Province, No. BACKGROUND: Duchenne muscular dystrophy is a cureless disease, it is a severe result of progressive atrophy of muscle cells, which caused by various defects.

背景:杜氏型肌营养不良的肌细胞损伤并非单一细胞受损,而是多因素缺陷导致肌细胞进行性萎缩的严重后果,患儿一经确诊即被告之无法医治。

For morphosis,young stage multifidus MRI charactered as full shape,evenness and regular outline,uniformity low signal,intramuscular spatia being revealed none or as single line,puncta form;however,old stage multifidus MRI charactered as atrophy shape,introcession outline,heterogeneity higher signal,intramuscularly spatial being revealed as multiple line-lamellar form or featheriness or grid form.

在形态结构方面,年轻组多裂肌表现为形态饱满、轮廓平整、均匀低信号、肌内间隙不显示或呈单个线状或点状显示;老年组多裂肌表现为形态萎缩、轮廓凹陷、信号不均匀性增高、肌内间隙呈多发线片状、羽毛状或网格状显示。

The prevalence and degree of fatty muscle atrophy were evaluated with magnetic resonance imaging in the abductor digiti minimi, flexor digitorum brevis, abductor hallucis, and quadratus plantae muscles in 80 asymptomatic volunteers (mean age, 48 years; range, 23-84 years) and 80 patients with foot pain (mean age, 48 years; range, 20-86 years).

对80例无症状志愿者(平均年龄48岁,范围23-84岁)和80例足痛患者(平均年龄为48岁,范围20-86岁)小趾展肌、趾短屈肌、拇展肌和足底方肌进行磁共振成像以估计脂肪肌内萎缩的发病率和程度。

Results The choice of operative method for the repair of chronic Achilles tendon rupture depended primarily on the length of tendon defect, the atrophic condition of triceps surae muscle, and the age and the sportive level of patient.

结果 陈旧性跟腱断裂手术修复方法的选择主要由肌腱断端间隙大小、小腿三头肌萎缩情况、患者的年龄和运动水平决定。

Objective To study survival motor neuron deletion in adult-onset patients with spinal muscular atrophy.

目的 探讨成年起病的脊肌萎缩症患者的运动神经元存活基因SMN的缺失情况。

An environment of simulated microgravity on ground was established, and its major effects on body-wall muscles of C.

这一学说是合理的,但是在细胞和分子水平导致肌萎缩的机制至今尚不完全清楚。

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