肌萎缩

BACKGROUND: Studies concerning muscle-derived stem cell transplantation mainly focused on treatment of muscular dystrophy. There are no studies on muscle-derived stem cells for treatment of denervated amyotrophy combined therapy.

背景：目前，国内外有关肌源性干细胞移植的研究主要集中在治疗肌营养不良性萎缩症方面，尚未见涉及将肌源性干细胞应用于失神经肌萎缩综合治疗的报道。

Results These two patients were confirmed to suffer from DMD. They were characterized by typical features of DMD including typical clinical manifestations, increased serum enzymes, EMG presenting myogenic impairment, HE staining presentation belonging to DMD, negative dystrophin in brother, and inconstantly positive on the sarcolemma of sister. Furthermore, no deletion or duplication was found in the 1-79 exons of dystrophin gene. The suffering brother and sister carried the same maternal X chromosome.

结果 兄妹二人符合DMD诊断，具有典型的DMD临床表现，肌酸激酶、肌酸激酶同工酶、乳酸脱氢酶、羟丁酸脱氢酶和谷草转氨酶的水平均显著高于正常值，肌电图呈肌源性损害，肌肉HE染色符合DMD，男患者的抗肌萎缩蛋白表达阴性，女患者的少量肌纤维仍可见不连续膜阳性，两患者抗肌萎缩蛋白基因的1~79号外显子未见缺失和重复突变，女患者与男患者携带相同的母源性X染色体。

This study was to evaluate the influence of masseter muscle on the craniofacial growth and development by using the botulinum neurotoxin to cause the masseter muscle atrophy.

中文摘要本研究目的是藉由将肉毒杆菌神经毒素注射入大白鼠咬肌，使咬肌萎缩，来探讨咬肌对颅颜型态及生长发育的影响。

Under the presupposition of no evident of muscle atrophy through maximal electrical twitch, quantitative electromyographical test of patellar reflex could discover the quadriceps AMI in patients with knee OA,which was known to be the inhibition of anterior horn motoneuron.

小结：在电刺激表明肌萎缩不明显的前提下，定量腱反射的肌电图检查显示膝OA的股四头肌有明显的AMI，此关节源性肌肉抑制为脊髓前角运动神经元的抑制。

Objective To observe the changes of myoblast prolifer ation dynamics of atrophic skeletal muscle after denervation in rats and their r elationship with muscle atrophy.

目的 观察大鼠骨骼肌失神经支配后肌萎缩和成肌细胞增殖动力学的动态变化及其与骨骼肌萎缩的关系。

DM1 and DM2 gene were amplified by PCR,tested by agarose electrophoresis, then analyzed by genetic analyzer. Results: Myotonia and muscle weakness were the main manifestations associated with heart block (7/8) and cataract (6/7). Electromyologram showed myopathic abnormalities not only in patients but also in other members of the family (5/6). The CTG repeats in DM1 and CCTG repeats in DM2 were all in normal range.

结果：该家系患者除有肌强直、肌萎缩等表现外；心电图检查：心脏传导阻滞(7/8)；裂隙灯检查：白内障(6/7)；肌电图检查：患者组有强直电位发放(5/5)，无临床症状成员也存在肌源性损害(5/6)；但该家系无DM1位点n和DM2位点n的重复数增加。

Transcription, western, and immunohistochemical analysis showed increased levels of dystrophin transcript and protein, and correct localization at the sarcolemma.

用免疫组织化学分析用纳米作为载体进行寡聚核苷酸递送的实验鼠抗肌萎缩蛋白基因RNA和抗肌萎缩蛋白的水平得到提高，而且恢复了抗肌萎缩蛋白在肌肉细胞膜上的正确位置。

Deletions that terminate in in-frame codons, do not prevent translation of dystrophin and result in a truncated protein, still able to bridge actin and sarcolemma.

缺失的终止在框架密码子，并没有妨碍在截短的抗肌萎缩蛋白翻译和结果，仍然能够弥合肌动蛋白，肌膜。

Results ①After 14 days of tail suspension, the ratio of wet weight of soleus muscle ...

结果 ①模拟失重14d后，比目鱼肌发生明显的萎缩，比目鱼肌湿重体重比由吊尾前的 38.8(mg·10 0 g- 1 )降低到 2 3.1，而吊尾加CLFS 14d后比目鱼肌湿重体重比仅下降到 32 。5 ，表明CLFS可有效的防止模拟失重所造成的肌萎缩。

To study the effects of skeletal muscle satellite cell on muscle atrophy so as to provide the experimental data for treating denervated muscle atrophy.

研究肌卫星细胞对萎缩肌肉的作用，为临床提高治疗失神经肌萎缩的疗效提供实验依据。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。