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肌细胞

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Background and Objective Pseudohypertrophic muscular dystrophy is a kind of lethal X-chain recessive inherited disease. The etiological factor is mainly due to gene mutation of Xp21 which induce the structural and functional abnormality of a kind of cell skeleton protein: dystrophin.

背景和目的假肥大型肌营养不良症(pseudohypertrophic muscular dystrophy,PMD)是一种常见的致死性X-连锁隐性遗传病,病因主要是由于X染色体短臂2区1带(Xp21)的基因突变而导致一种细胞骨架蛋白——抗肌萎缩蛋白的结构和功能异常所致。

The sarcoplasmic reticulum enlarged gradually at 1 day,and it was obvious about the nucleous and under the membrane.

超微结构显示术后1 d心肌细胞肌浆网逐渐扩张,术后5 d尤以核周和肌膜下明显。

The model in rats with the third lumber vertebrae transverse process syndrome was established by inserting absorbable gelatin sponge into the deep subfascial part of the 3rd lumbar transverse process.

结果:1造模第2天到第14天干预治疗前,与正常组相比,手术各组大鼠痛阈降低(P<0.05)。28天和56天病理显示肌组织有炎性细胞的浸润,结缔组织增生,肌束膜增厚。

To study the effects of skeletal muscle satellite cell on muscle atrophy so as to provide the experimental data for treating denervated muscle atrophy.

研究肌卫星细胞对萎缩肌肉的作用,为临床提高治疗失神经肌萎缩的疗效提供实验依据。

Acceptable resolutions were achieved when it was applied for the separation of dipeptides including Leu-Tyr and Val-Tyr by using 1-butanol-acetic acid-water (4:1:5, V/V/V) solvent system. The proteins including cytochrome C and myoglobin, lysozyme and myoglobin, and fresh chicken egg-white proteins were well separated by 12.5% PEG1000-12.5% K2HPO4-75% water (pH 9.0) and 16% PEG 1000-12.5% K2HPO4-71.5% water (pH 8.0) system.

应用研究表明,采用正丁醇-醋酸-水(4:1:5, V/V/V)和PEG1000-磷酸钾盐-水(12.5:12.5:75, W/W/W)(pH 9.0)体系可以在较高的流动相流速和较高的固定相保留下分别实现对亮氨酸-酪氨酸和缬氨酸-酪氨酸二肽混合物以及细胞色素C与肌红蛋白、肌红蛋白与溶菌酶混合物及鸡蛋清样品中蛋白成分的成功分离。

Objective To investigate the effects of long-te rm application of cathartics on electromyography of rat colon and to explore the role of interstitial cells of Cajal in it.

目的 研究长期服用刺激性泻剂对大鼠结肠肌电的影响,探讨Cajal间质细胞在&泻剂结肠&肌电变化中的作用。

The treated mice had high levels of dystrophin produced in their muscles, including the heart.

接受治疗的杜氏进行性肌营养不良实验鼠的肌肉细胞中中产生了高水平的抗肌萎缩蛋白的表达。

The rate of enteric transit was measured, and the histological changes in nitriergic nerves in intestinal myenteric plexus of scalded rat were observed as well. The densities of neurons and ganglions with positive nitric oxide synthetase as well as ICC in duodenal myenteric plexus were assessed for both groups.

用酶组织化学方法观察回肠肌间神经丛内氮能神经的组织学改变,并对两组大鼠回肠肌间神经丛内一氧化氮合酶阳性神经元、神经节和Cajal间质细胞的密度进行测定。

All the indexes were tested in 2 -. 4 .. 6 weeks of operative intervals respectively. Results:(1) The general observation in the experimental group ,such as spirit, hair, body weight and activity ,was superior to that in the control group.(2) The recovery rate of sciatic nerve functional index (SF1) was statistically significantly higher in the experimental group than in the control group .(3) electrophysciological indexes: m the experimental group ,the tardy rate of induced motorius action potential ,recovery rates of the amplitude of compound muscle action potential and twitch tension and tetanic tension of triceps surae muscle ,were significantly higher than in the control group.(4) Compared with the control group ,the triceps surae muscle wet weight was significantly greater in the experimental group.(5) histomorphological indexes: the count of myelinated nerve fibers ,diameter of regenerated axon, thickness of nerve myelin sheath and area of capillary were much more in the experimental group than in the control group.(6) observation of ultrastructure with the transmission election microscope: more abundant organell a and maturer myelin sheath lay in the injured peripheral nerve of the experimental group, while not lay in the control group.

分别在木后第2、4、6周时进行各项指标的检测,结果发现:(1)实验组SD大鼠在整个实验过程中,其精神、毛发、体重,运动灵活性等一般情况优于对照组;(2)实验组的坐骨神经功能指数恢复率显著优于对照组,P<0.01;(3)神经电生理指标:实验组运动神经诱发电位潜伏期的延迟率显著优于对照组,P<0.05;复合肌肉动作电位振幅的恢复率显著高于对照组,两组比较第2周时P<0.01,第4、6周时,P<0.05;小腿三头肌单收缩力和强直收缩力的恢复率实验组显著高于对照组,P<0.01;(4)小腿三头肌湿重的恢复率,第2、4周时实验组高于对照组,差异非常显著,P<0.01;第6周时,差异仍显著,P<0.05;(5)组织形态学指标:有髓种经轴突计数、再生轴突直径的恢复率,毛细血管面积,实验组均显著大于对照组,P<0.01、P<0.05、P<0.001;实验组髓鞘厚度的恢复率也显著高于对照组,第2周时P<0.01,第4、6周时,P<0.05;(6)透射电镜超微结构观察:实验组再生轴突中细胞器丰富,髓鞘结构成熟,神经再生情况优于对照纽。

In the course of experimental study on re-perfusion of ischemic skeletal-muscle graft, Zamboni found that HBO could reduce leukocyte adhering to endothelia and infiltrating.

有学者在对肌瓣移植的缺血再灌注损伤进行实验研究时发现:HBO能够减少白细胞与血管内皮细胞粘附,并减少白细胞的浸润,减轻局部的炎症反应,从而减轻肌瓣的缺血再灌注损伤。

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