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We report the case of a congenital myasthenic syndrome due to a mutation in AGRN, the gene encoding agrin, an extracellular matrix molecule released by the nerve and critical for formation of the neuromuscular junction.

我们报告了一例由于AGRN集聚蛋白编码基因)突变导致的先天性肌无力综合征,AGRN是一种由神经释放的细胞外基质分子并对神经肌肉接头的形成起重要作用。

Operative design: After gastric anterior wall was exposed, any Crow's nerve was identified from antral surface nearby gastric angle. Along the Crow's nerve, Latarjet nerve was found, gastric branches of Latarjet were gradually severed, the dissection proceeds to up towards the diaphrageal fissula, and then, the right gastroepiploic neurovascular bundle was cut, the distal two-thirds of the greater curvature was mobilized by dividing the greater omentum, the posterior nerve of Latarjet may be seen and isolated in the same way.

手术设计:暴露胃前壁,自胃角附近的胃窦壁表面任意找到一支&鸦爪&支迷走神经,随以此支为标志向上找到分出该鸦爪的Latarjet氏神经干,顺该神经向上游离,分离中避开向右走行的肝支及胃小弯的主要血管,逐一切断走向胃壁的迷走神经分支,直游离到膈肌食管裂孔平面。

The Movement Disorder Society is an international professional society of clinicians, scientists, and other healthcare professionals, who are interested in Parkinson's disease, related neurodegenerative and neurodevelopmental disorders, hyperkinetic movement disorders, and abnormalities in muscle tone and motor control.

运动紊乱协会是由临床医生、科学家和其它保健专业人员组成的国际专业协会,这些专业人员都对帕金森病、神经退化或神经发育的相关疾病、运动机能亢奋及肌张力与动作控制的异常情形感兴趣。

The Movement Disorder Society is an international professional society of clinicians, scientists, and other healthcare professionals, who are interested in Parkinson's disease, related neurodegenerative and neurodevelopmental disorders, hyperkinetic movement disorders, and abnormalities in muscle tone and motor control.

运动紊乱协会是由临床医生、科学家和其它健康保健专业人员组成的国际专业协会,这些专业人员都对帕金森病、神经退化或神经发育的相关疾病、运动机能亢奋及肌张力与动作控制的异常情形感兴趣。

BACKGROUND: Facial nerve defect seriously impacts the mental and physical health of patients as well as their quality of life. Pediceled neck muscle transplant and autologous nerve transplant have been used in clinical to repair facial nerve defect and restore the facial muscle function. However,there are disadvantages and limits of above methods which have restricted their wide application of them. It is a research hotspot for looking for a new material to repair facial nerve defect.

背景:面神经缺损严重影响患者身心健康及生活质量,临床采用较多的有带蒂颈肌移植术和自体神经移植术等修复面神经缺损,恢复面肌的功能,但上述方法均有其缺点和局限性,使其广泛应用受到限制,寻求一种新的修复面神经缺损的材料是目前研究的热点。

The present invention is directed to substituted propylamine derivatives of formula I or a pharmaceutically acceptable salt thereof, compositions containing these derivatives, and methods of their use for the prevention and treatment of conditions ameliorated by monoamine reuptake including, inter alia, vasomotor symptoms, sexual dysfunction, gastrointestinal and genitourinary disorders, chronic fatigue syndrome, fibromylagia syndrome, nervous system disorders, and combinations thereof, particularly those conditions selected from the group consisting of major depressive disorder, vasomotor symptoms, stress and urge urinary incontinence, fibromyalgia, pain, diabetic neuropathy, and combinations thereof.

本发明涉及式I的取代丙胺衍生物或其医药学上可接受的盐、含有这些衍生物的组合物、和其用于预防和治疗通过单胺再摄取改善的病状的使用方法,所述病状尤其包括血管舒缩症状、性功能障碍、胃肠道和泌尿生殖道病症、慢性疲劳综合症、纤维肌痛综合症、神经系统病症和其组合,特别是那些选自由严重抑郁症、血管舒缩症状、压力性和急迫性尿失禁、纤维肌痛、疼痛、糖尿病性神经病变和其组合组成的群组的病状。

There were tow types of courses of the dorsal nerve,one was that the nerve passed over the surface of the middle scalenus muscle from antero-in...

肩胛背神经起始部走行方式及其与中斜角肌比邻中的致密的纤维组织,是该神经易造成卡压的形态学基础

At postnatal 1st week immunopositive reaction of NGF was detected mainly in sustentacular cells and the spermatogonia also showed positive staining. NGF positive staining in the testes was observed in interstitial cells, spermatogenetic cells, sustentacular cells and Leydig cells at 3rd week. After the postnatal 5th week, NGF-positive immunostaining was also detected in intersitial cells and spermatogenetic cells, but the intensity of reaction was weaker than that at 1st and 3rd weeks.

免疫组化定位分析显示:睾丸组织的神经生长因子蛋白表达于小鼠出生后的各个时期内,1周龄睾丸组织免疫阳性反应主要位于支持细胞,精原细胞也有着色;3周龄睾丸组织的间质细胞、各级生精细胞、支持细胞、管周肌样细胞表达均呈现阳性;5周后的睾丸组织内神经生长因子呈低水平表达,主要表达于间质细胞和生精细胞内。

The level of neuromuscularblockade was assessed by recording the amplitude of compoundmuscle action potentials (T1) from the abductor hallucis brevismuscle in response to supramaximal electrical stimulation ofthe median nerve at the wrist.

通过记录对腕部正中神经超强电刺激的反应中的拇外展短肌复合肌肉动作电位(T1)的幅度来评估神经肌肉阻滞的水平。

Results 1、Results of gross anatomy Through the gross anatomy study of calfs and clinical common used muscular flaps, we discover that some muscles can be divided into several parts.

3肌肉分类的方法:根据Lim等人对上肢肌的分类方法,再结合本实验大体解剖和肌内神经染色的结果,对本实验中的肌肉进行分类,提出肌肉的亚部化观点。

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