肌氨酸

Results: The changes following hydrocortisone intervention of rats could be identified by PCA, and the kidney deficiency syndrome rats entered a state of "hyperfunction", involving a series of changes in metabolic pathway and metabolic network. The response integral area of lactic acid (δ 1.37) increased, indicating the accumulation of metabolites of lactic acid. The amount of dimethylamine (δ 2.72) also increased, indicating that the disorder of kidney function was related to kidney-deficiency syndrome. The response of creatinine (δ 3.87), asparaginic acid (δ 2.83), taurine (δ 3.44, 3.28), and hippurate (δ 7.84, 7.56, 7.64, 3.97) all decreased significantly, indicating that the hydrocortisone might cause adrenal cortex excretion injury. The response integral area of succinate (δ 2.41) and citric acid (δ 2.53, 2.68) decreased, which was usually caused by disorder of the mitochondrial function.

结果：PCA方法处理肾虚证和空白对照大鼠尿液数据显示，两组大鼠的数据可以在得分图实现分类，与对照组比较肾虚组大鼠由于氢化可的松诱导，大鼠机体进入一个过消耗后衰弱的状态，相关代谢发生显著变化，乳酸(δ 1.37)代谢发生堆积；二甲胺(δ 2.72)的含量增加，提示肾虚与肾功能异常是密切相关的；天冬氨酸(δ 2.83)，牛磺酸(δ 3.44， 3.25)，马尿酸(δ 7.84， 7.56， 7.64， 3.97)，肌氨酸(δ 3.87)等的相对积分面积明显下降，这预示糖皮质激素可能引起了肾上腺皮质分泌功能的损害；琥珀酸(δ 2.41)和柠檬酸(δ 2.53， 2.68)是三羧酸循环能量代谢及糖酵解的中间产物，其含量的降低，通常是由于线粒体功能紊乱所引起。

Creatininase could be induced by the reagents such as creatinine, creatine, sarcosine, choline chloride and urea. Mn(superscript 2+) Co(superscript 2+) could remarkably increased the productivity of creatininase.

诱导物肌酐、肌酸、肌氨酸、氯化胆碱和尿素可以诱导酶的产生，Mn(上标 2+)、Co(上标 2+)对酶的产生有促进作用。

In this paper, firstly using natural fatty acids including lauric acid, myristic acid, palmitic acid etc. and disproportionated rosin as starting materials, the acyl reaction of starting materials with SOCl_2 respectively, and then using Schotten-Baumann condensation: on the reaction conditions of alkalescence, condensation of acylchloride with amino acid (sarcosine, glycine, alanine etc.), and then acidification, saltation. A series of anionic surfactants of N-acyl amino: sodium N-fatty acyl sarcosinate (SFS-12, SFS-14, SFS-16); sodiun N-fatty acyl glycinate(SFG-12, SFG-14, SFG-16); sodium N-fatty acyl alaninate(SFA-12, SFA-14, SFA-16)and sodium N-disproportionated rosinoyl aminatewere prepared. During the preparation of N-acylamino acid, the reaction conditions of acylchloride with amino acid condensation were identified by optimizing the synthetic conditions of N-lauroyl sarcosine: mol ratio of amino acid to acylchloride 2:1, reaction taken place in a solvent composed by acetone/water 2:1, acylchloride and 20% NaOH were slowly added to the reaction mixture at the same time while maintaining the pH at 9~10, after completion of adding maintaining reacting for 2.5h at 25℃.

首先以月桂酸、肉豆蔻酸、棕榈酸等天然脂肪酸和歧化松香为原料，与氯化亚砜反应制得酰氯，然后采用Schotten-Baumann 缩合法路线，即在碱性条件下，酰氯和氨基酸(肌氨酸、甘氨酸、丙氨酸等)缩合，经过酸化、成盐，合成一系列氨基酸型阴离子表面活性剂：脂肪酰肌氨酸钠，即月桂酰肌氨酸钠(SFS-12)、肉豆蔻酰肌氨酸钠(SFS-14)、棕榈酰肌氨酸钠(SFS-16)；脂肪酰甘氨酸钠，即月桂酰甘氨酸钠(SFG-12)、肉豆蔻酰甘氨酸钠(SFG-14)、棕榈酰甘氨酸钠(SFG-16)；脂肪酰丙氨酸钠，即月桂酰丙氨酸钠(SFA-12)、肉豆蔻酰丙氨酸钠(SFA-14)、棕榈酰丙氨酸钠(SFA-16)；N-歧化松香酰基氨基酸钠(sodium N-disproportionated rosinoyl aminate)，即N-歧化松香酰基肌氨酸钠(sodium N-disproportionated rosinoyl sarcosinate ，简称SDRS)、N-歧化松香酰基甘氨酸钠(sodium N-disproportionated rosinoyl glycinate，简称SDRG)、N-歧化松香酰基丙氨酸钠(sodium N-disproportionated rosinoyl alaninate，简称SDRA)。

The circulation, consumption and reproduction of the trilogy have not only testified to its historical significance and literariness, but also invested it with new meanings.

该三部曲的流通、消费与再生产不仅验证了其历史意义及文学性，而切还赋予它以新的意义。

If he thought that he could buy me off, he would be wrong.

如果他认为他可以收买我，那他就大错特错了。