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The ultramicrostructure in atrial myocytes displayed glycogen aggregation, karyopycnosis, sarcoplasmic reticulum distention and chondriosome swelling at 24 hours after rapid pacing.

经过24 h的快速起搏,心房肌细胞出现糖原聚集、核固缩、空泡样变以及肌浆网扩张、线粒体肿胀、部分线粒体嵴轻度溶解等超微结构的改变。

Results Transient myocardial ischemia/reperfusion induced obvious accumulation of KEF 4 mRNA in rat. Oxidative stress distinctly raised the KLF 4 mRNA and protein levels in C2C12 cells.

结果 短暂缺血再灌注后,大鼠心肌组织中Krüppel样因子4mRNA的水平明显增加;过氧化氢处理C2C12肌原细胞后,Krüppel样因子4mRNA和蛋白的水平均明显增加。

Results With the expression in normal salivary gland as a standard, low C-erbB-2 mRNA expression was seen in adenolymphoma, basal cell adenoma. However, various degrees of over-expression of C-erbB-2 oncogene mRNA were detected in pleomorphic adenoma, mucoepidermoid carcinoma,acinic cell carcinoma ,adenoid cystic carcinoma ,papillary cystic carcinoma,and myoethelial cell carcinoma.

结果 正常涎腺和涎腺肿瘤中发现不同程度C-erbB-2mRNA的表达,以正常涎腺组织的表达水平为基准,在腺淋巴瘤、基底细胞腺瘤呈现低表达、无表达或与正常涎腺组织表达水平相似,多形性腺瘤、粘液表皮样癌、腺泡细胞癌、腺样囊性癌、乳头状囊腺癌和肌上皮癌则呈现不同程度的过表达。

Results The tissue of 3 cases of ACC in the esophagus was mainly composed of square shape gland epithelial cell and variant myoepithelial cell, mesh shape cavity crack and the tubular, the entity shape arrangement, the cavity crack content basophilia and acidophilia the secretion. There was transmigration of superficial epidermis in 1 case of ACC; All 3 cases were positive of CK, H-CK, P63, S-100 (endochylema /nucleus), EMA, and Bcl-2. Case 3 was positive of CerbB-2 and P53. Case 2 was CD117, AAT, SMA, PAS/AB.

结果 3例食管腺样囊性癌的癌组织主要由立方形腺上皮细胞和变异的肌上皮细胞组成,呈筛孔状腔隙、管状、实体状排列,腔隙内含嗜碱性和嗜伊红分泌物;3例食管腺样囊性癌中例1表面上皮有移行;免疫组化:3例CK、H-CK、P63、S-100、EMA、Bcl-2均,例3 CerBb-2,P53,例2 CD117,AAT、SMA,PAS/AB。

The function of bile canaliculi was assessed by observation of the tran...

E2促进大鼠三维培养的肝细胞胆汁分泌,在RhoA和radixin介导下肌动蛋白重新分布,细胞骨架再建,调节紧密连接功能和聚集,导致毛细胆管样结构的扩张和三维培养时球状体空泡样结构的形成。

A total of 90 healthy male Sprague Dawley rats were selected for this study. Twelve rats were used for the sham operation group. Left anterior descending coronary artery of the remaining rats was deligated to establish models of myocardial infarction. After 24 hours of deligation, 36 rats were randomly divided into the control group and experimental group, 18 rat in each group.

目的:检测人胰岛素样生长因子Ⅰ基因修饰的鼠骨骼肌成肌细胞移植后,心肌梗死大鼠血浆及心肌组织内胰岛素样生长因子Ⅰ蛋白浓度的变化,以及心肌细胞内胰岛素样生长因子Ⅰ和端粒酶反转录酶mRNA水平的表达。

A total of 150 mesenchymal neoplasms of the GI tract, abdominal cavity, and retroperitoneum were retrieved from consult and surgical pathology archives, including 54 GISTs (8 KIT-negative; 13 desmin-positive), 17 GI leiomyosarcomas, 11 GI mural leiomyomas, 13 leiomyomas of the muscularis mucosae, 12 gastric schwannomas, 15 inflammatory myofibroblastic tumors, 9 cases of mesenteric desmoid fibromatosis, 10 dedifferentiated liposarcomas, and 9 malignant peripheral nerve sheath tumors.

我们从会诊病例及活检病例中找出150例间叶性肿瘤(来自胃肠道、腹腔和后腹膜),其中包括54例GISTs(8例KIT阴性、13例desmin阳性)、17例GI道平滑肌肉瘤、11例GI道肌壁间平滑肌瘤、13例GI道粘膜肌层平滑肌瘤、12例胃的神经鞘瘤、15例炎性肌纤维母细胞瘤、9例肠系膜韧带样纤维瘤、10例去分化型脂肪肉瘤和9例恶性外周神经鞘膜瘤。

objective to explore the reasonable utilization of cephalosporins in chronic renal failure patients with cephalosporin encephalopathy.method we retrospectively analyzed the clinical characteristics of 29 crf patients,who developed encephalopathic syndrome and was treated with cephalosporin.results the encepha1opathic syndrome include (1)mental confusion in 4 cases;(2)unconsciousness in 2 cases;(3)seizure in 23 cases.physical examination did not show signs of cerebral focal injury.computed tomography of the brain in 29 patients did not show acute lesions.the state of neurotoxicity was completely recovered after discontinuation of cephalosporins.conclusion cephalosporins used in conventional doses or reduced doses can cause temporary encephalopathy in patients with crfwhich might due to prolongation of drug half life.

目的 通过研究慢性肾功能衰竭患者抗生素脑病的发病机制和临床特点,探讨头孢菌素在crf患者中的合理应用。方法 29例crf患者在使用常规剂量或减量使用头孢菌素后出现神经精神症状,诊断为抗生素脑病,将其临床资料进行回顾性分析。结果神经精神症状表现多样:(1)精神异常4例,表现为胡言乱语、烦躁不安、睡眠倒错;(2)意识障碍2例,表现为嗜睡、昏睡、神志不清;(3)癫痫样抽搐23例,表现为肌阵挛、全身抽搐、癫痫样发作;部分患者同时出现几组症状。所有患者均无神经系统定位体征,行颅脑ct检查无急性病变。

We evaluated 350 tumors: 136 ES, including 64 conventional ES, 64 proximal-type ES, and 8 with hybrid features of conventional and proximal-type ES; 54 metastatic carcinomas (22 from lung, 6 breast, 6 stomach, 5 colorectum, 5 kidney, 5 prostate, 5 pancreas); 12 metastatic testicular embryonal carcinomas; 20 metastatic melanomas; 20 epithelioid mesotheliomas; 20 epithelioid angiosarcomas; 10 epithelioid hemangioendotheliomas; 24 epithelioid malignant peripheral nerve sheath tumors; 22 myoepithelial carcinomas of soft tissue; 7 anaplastic large cell lymphomas; 5 histiocytic sarcomas; and 10 control MRT of infancy (4 brain, 3 liver, 2 soft tissue, 1 kidney).

我们总共研究了350例肿瘤:136例ES,其中包括64例寻常型ES、64例近端型ES和8例混有前两型特征的混合型ES;54例转移癌(22例来自肺、6例来自乳腺、6例来自胃、5例来自结直肠、5例来着肾、5例来着前列腺、5例来着胰腺);12例转移性睾丸胚胎性癌;20例转移性黑色素瘤;20例上皮样间皮瘤;20例上皮样血管肉瘤;10例上皮样血管内皮瘤;24例上皮样恶性外周神经鞘膜瘤;22例软组织的肌上皮癌;7例间变性大细胞淋巴瘤;5例组织细胞肉瘤;10例作为对照的婴幼儿MRT(4例位于脑、3例位于肝、2例位于软组织、1例位于肾)。

Others injected MSCs into autoallergic myocardial tissue directly, observed some caridomyocyto-like cells formation capable of cardiomyocyte specific marking of troponin T and myoglobulin heavy-chain positive staining, which proved that MSCs can be induced into myocardial cells in microenviroment in vivo.

另有学者将MSCs直接注入自体心肌组织内,发现有心肌样细胞形成,具有肌钙蛋白T和肌球蛋白重链染色阳性的心肌细胞特异性标志,表明MSCs在体内微环境条件下可以诱导分化为心肌细胞。

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