肌发生的

A clear cause-and-effect relationship between excessive myocardial MMP-1 activity, increased mysial collagen degradation, and progression to systolic HF has been shown experimentally through the use of transgenic models and the use of pharmacological MMP activators.53,54 In addition, experimental evidence has been provided showing that following chronic neurohormonal activation, increased synthesis and release of MMPs into the local extracellular matrix of the cardiomyocyte occurs,55 which in turn could contribute to endomysial and perimysial collagen degradation and disruption.

一个明显的因果过多的心肌MMP-1关系活动， mysial增加胶原蛋白的降解和进展收缩性心力衰竭已被证明试验，通过使用转基因模型和使用的MMP药理作用此外，activators.53，54实验证据下面被提供显示慢性神经激活时，增加的MMPs合成和释放到当地的细胞外基质的心肌细胞发生，55反过来有助于人肌内膜和 perimysial胶原退化和破坏。

Sustained AF could be induced easily in all dogs during vagal nerve stimulation in vivo both before and after isolation of all PVs with encircling lesions created by a bipolar radiofrequency ablation clamp device. PV elimination had no effect on atrial effective refractory period or its responses to cholinergic stimulation. Autonomic ganglia were identified by bradycardic and/or tachycardic responses to high-frequency subthreshold local stimulation. Ablation of the autonomic ganglia overlying all PV ostia suppressed the effective refractory period-abbreviating and AF-promoting effects of cervical vagal stimulation, whereas ablation of only left- or right-sided PV ostial ganglia failed to suppress AF.

无论是在双极环状消融所有PV之前或之后，在体刺激颈迷走神经节过程中持续性房颤在所有犬均能轻易被诱导出，PV切除对心房肌的有效不应期或对胆碱的反应均没有影响，通过对高频的域下刺激发生快速或慢速反应来鉴定自主神经节，消融叠加于PV口部的自主神经节能抑制有效不应期的缩短、和刺激颈迷走神经诱发的房颤促进作用，而仅消融左或右侧PV口部的自主神经节却不能抑制房颤。

In this study we provide evidence that inhibition of Rho kinase activation or myosin contractility abrogates PMA-induced apoptosis, and turns cells to undergo PMA-induced differentiation program, suggesting a switching role for the RhoAJROCK/myosin contraction pathway in cell fate decision.

在我们的研究中发现抑制Rho kinase 的活性或肌动蛋白收缩将阻断凋亡的发生，而使细胞全数走向分化，证实了RhoA/RocK 活化所造成的myosin 滑动收缩的机制，对细胞因应刺激而决定其命运的过程中扮演一决定性角色。

All 21 exons with flanking intronic sequences, as well as a 263 bp fragment of the 5" flanking region, of GARS-AIRS-GART gene, were screened in the same five populations, by the method of PCR-SSCP analysis, combined with sequencing reactions. We detected 10 SNPs, C-179T from 5" flanking region, A5669G form exon 3, C6545Afrom exon 4, A7777G from intron 4, G10854T, C10867T, G10898T from intron 6, A16197G from intron 11, C21228T from intron 14, and C29686T from exon 21. These ten polymorphic sites were nominated as GARS1, GARS2, GARS3, GARS4, GARS5, GARS6, GARS7, GARS8, GARS9, and GARS 10, respectively. The mutation of C D A at GARS3 was a non-synonymous mutation, wh

其中外显子4中的6545处的c~A突变导致对应的氨基酸序列中的第173位氨基酸发生变异：天冬氨酸一谷氨酸；10个SNP位点依次命名为：GARSI、GARSZ、GARS3、GARS4、GARSS、GARS6、GARS7、GARSS、GARSg、GARS 10；(2)10个SN'P位点在不同的鸡种中的基因型分布差异显著(P.05)，进一步的方差分析显示，GASRI位点以及GARS3位点与肌肉肌昔酸含量之间存在着显著的关联；(3)在所检测的5个群体中GARsl位

In the negative and interrogative forms, of course, this is identical to the non-emphatic forms.

。但是，在否定句或疑问句里，这种带有"do"的方法表达的效果却没有什么强调的意思。

Go down on one's knees;kneel down

屈膝跪下。。。下跪祈祷