肌丝

The major function of nebulin is to act as a unique regulator of thin filament length, a vital modulator of actomyosin sliding, and a biomolecular sensor of signal transduction.

Nebulin主要功能为扮演细肌丝长度的独特性调节者，肌凝蛋白与肌动蛋白滑动之不可或缺的调控者，以及讯息传递的生物分子成应者。

Moreover, chondriosome hypertrophy and vacuolar degeneration were found. The damage lessened in SVitC and LVitC groups. Both myofilaments and sarcomeres in IVIG and IVIG+VitC groups were almost normal, and the chondriosome was normal.

6心肌的电镜检测：对照组心肌肌丝排列紊乱，肌节断裂严重，线粒体肥大，并出现空泡变性；大、小剂量VitC组病变比对照组有所减轻；IVIG组和IVIG+VitC组肌丝排列紊乱明显减轻，肌节断裂比对照组减少，线粒体基本正常。

Transmission electron microscope showed the evident damage of hypoxic cardiocyte ultrastructure after blocking HSP90: caryotheca crenation, chromatin margination and mitochondria vacuole.

(3)透射电镜显示阻断HSP90后的缺氧心肌细胞超微结构不但出现细胞肿胀，肌丝排列紊乱等细胞受损的表现，还可以看到核膜皱缩，染色质边集，线粒体出现空灶化等细胞凋亡的特征。

This kind of bilattice structure differs obviously from the myofibril monolattice structure with the RTTF at 3:1 of sounding muscle of cicadas singing in mono-toned song.

FSM和SSM虽然由粗肌丝构成相同的阵列骨架，但细肌丝对粗肌丝的比例不同，分别为3：1和5：1。

Results myofilament and myotome in fosinpril group were normal on the whole under the electron microscope, but myofilament of the ischemia-reperfusion group was broken and the intercalated disc was not clear.

结果：福辛普利组电镜下肌丝肌节清晰，而缺血再灌注组闰盘结构不清，肌丝断裂。

Instead, sarcomere shortening occurs when the thin filaments "slide" by the thick filaments.

此外，肌节的缩短发生于细肌丝沿粗肌丝"滑行"之际。

Titin is recently known as the largest protein which exists in the stiated muscle sarcomere and is dynamic both in biomechanics properties and biochemical functions. Four possible disease-associated mutations located in three exons(3,14,49) of titin gene have been identified in Japanese DCM patients in 2002. But we did nothing about the creative titin and DCM.

目的：肌联蛋白是由单基因编码的最大蛋白，普遍存在于心肌和骨骼肌，被称为第三肌丝，具有复杂的生物力学性质和生物化学功能。2002年日本研究人员报道了肌联蛋白基因第3、14、49外显子的4个基因突变可能与扩张性心肌病发病相关，而我国没有相关的研究报道。

2Myocardial ultrastructure was normal in the control group,myoneme arranged disordered,the structure of typical sarcomere disappeared, mitochondrium intumesced,interstitial substance fiber hyperplasy,capillary vessel endothelial cell swelled in DG group.Myocardial ultrastructure improved slightly in rats of SM and LM groups. 3NF-κB p65 and COX-2 had a small quantity to present in the myocardium tissue of control group,while the quantity increased obviously in the diabetic group.The level of it in the group of treatment was significant lower than that in the diabetic group.There was significant difference between the two groups. Conclusion Metformin can protect against the heart injury in diabetic.

结果 1与对照组比较，DG组体重明显减轻，血糖、心脏质量指数、INS、TG、T-CH及FFA明显升高(P＜0.01)；应用 MT治疗后体重无明显增加，INS有所下降，心脏质量指数、血糖、TG及FFA明显降低(P＜0.01)；DG组心肌组织MDA明显升高，SOD明显降低(P＜0.01)，MT治疗后上述指标明显改善；2超微结构观察单纯糖尿病组肌丝结构明显紊乱，典型肌小节结构消失，线粒体肿胀、间质纤维增生，微血管内皮细胞肿胀等表现，而SM及LM组可见组织结构有所改善；3对照组心肌NF-κB p65及COX-2只有少量表达，单纯糖尿病组表达量明显增多(P＜0.01)，MT治疗后表达量明显减少(P＜0.01)。

Fig 5 In experimental group, mitochondrion in SO cell congregated at one end and nuclear with vacuolization and concentration of chromatin congregated at brim of nuclear

图4 实验组SO细胞肿胀，细肌丝疏松，排列紊乱致细肌丝结构不清。密体分布不均，形态大小及其长轴与细肌丝排列方向成角

Furthermore, it was noticed that there was clearly higher myofilaments density in superficial and intermediate lamellae than the deep one.

电镜观察进一步验证了酶组化的结果，并首次发现浅层肌和中间肌细胞肌丝密度明显大于深层肌。

Singer Leona Lewis and former Led Zeppelin guitarist Jimmy Page emerged as the bus transformed into a grass-covered carnival float, and the pair combined for a rendition of "Whole Lotta Love".

歌手leona刘易斯和前率领的飞艇的吉他手吉米页出现巴士转化为基层所涵盖的嘉年华花车，和一双合并为一移交&整个lotta爱&。

This is Kate, and that's Erin.

这是凯特，那个是爱朗。