肌上皮的

Objective To investigate the changes of myoepithelial cells in mammary atypical hyperplasia and breast cancer.

目的 观察肌上皮细胞在乳腺不典型增生及乳腺癌中的变化。

The strong positive expression located in the gland alveolus and duct of serous gland, as well as myoepithelium of mucus glands. In some cases, blood vessel endothelium and fibrous connective tissue also show weakly positive expression of NF-κB.

NF-κB的表达主要见于浆液腺腺泡上皮和导管上皮，呈强阳性表达；黏液腺肌上皮样上皮呈强表达；间质成分中血管内皮呈弱阳性表达、纤维结缔组织呈弱阳性表达。

The changes included that the protrusions on the cell surface diminished, myofilaments and pinosomes in the myoepithelial cells of grade Ⅱ,Ⅲ atypical hyperplasia decreased, and the irregularity of the nuclear morphosis and the increase of nuclear heterochromosome were found.

乳腺不典型增生时肌上皮细胞数目增多，排列紊乱，电镜下可见：①细胞表面的棒状突起消失；②Ⅱ、Ⅲ级不典型增生时胞浆内的肌微丝和吞饮小泡减少；③细胞核增大，不规则，异染色质增多。

The mean proportional volumes of mucous acini were more than those of serous acini except salivary glands of rodents.Conclusion: The mean proportional volume of MeCs in salivary glands associates with animal species and secretion of salivary glands.

HHF 35是近几年开始使用的识别特异性肌动蛋白（muscle-actin-specific）的单克隆抗体，作者使用它来区别肌上皮细胞和腺泡，希望通过定量测定比较肌上皮细胞的平均体积比，以了解不同动物涎腺中肌上皮细胞的发育是否存在物种间的差异及与分泌功能的关系。

Results The tissue of 3 cases of ACC in the esophagus was mainly composed of square shape gland epithelial cell and variant myoepithelial cell, mesh shape cavity crack and the tubular, the entity shape arrangement, the cavity crack content basophilia and acidophilia the secretion. There was transmigration of superficial epidermis in 1 case of ACC; All 3 cases were positive of CK, H-CK, P63, S-100 (endochylema /nucleus), EMA, and Bcl-2. Case 3 was positive of CerbB-2 and P53. Case 2 was CD117, AAT, SMA, PAS/AB.

结果 3例食管腺样囊性癌的癌组织主要由立方形腺上皮细胞和变异的肌上皮细胞组成，呈筛孔状腔隙、管状、实体状排列，腔隙内含嗜碱性和嗜伊红分泌物；3例食管腺样囊性癌中例1表面上皮有移行；免疫组化：3例CK、H-CK、P63、S-100、EMA、Bcl-2均，例3 CerBb-2，P53，例2 CD117，AAT、SMA，PAS/AB。

We evaluated 350 tumors: 136 ES, including 64 conventional ES, 64 proximal-type ES, and 8 with hybrid features of conventional and proximal-type ES; 54 metastatic carcinomas (22 from lung, 6 breast, 6 stomach, 5 colorectum, 5 kidney, 5 prostate, 5 pancreas); 12 metastatic testicular embryonal carcinomas; 20 metastatic melanomas; 20 epithelioid mesotheliomas; 20 epithelioid angiosarcomas; 10 epithelioid hemangioendotheliomas; 24 epithelioid malignant peripheral nerve sheath tumors; 22 myoepithelial carcinomas of soft tissue; 7 anaplastic large cell lymphomas; 5 histiocytic sarcomas; and 10 control MRT of infancy (4 brain, 3 liver, 2 soft tissue, 1 kidney).

我们总共研究了350例肿瘤：136例ES，其中包括64例寻常型ES、64例近端型ES和8例混有前两型特征的混合型ES；54例转移癌（22例来自肺、6例来自乳腺、6例来自胃、5例来自结直肠、5例来着肾、5例来着前列腺、5例来着胰腺）；12例转移性睾丸胚胎性癌；20例转移性黑色素瘤；20例上皮样间皮瘤；20例上皮样血管肉瘤；10例上皮样血管内皮瘤；24例上皮样恶性外周神经鞘膜瘤；22例软组织的肌上皮癌；7例间变性大细胞淋巴瘤；5例组织细胞肉瘤；10例作为对照的婴幼儿MRT（4例位于脑、3例位于肝、2例位于软组织、1例位于肾）。

An inner layer of epithelial cells, the secretory portion of the gland, is surrounded by a layer of flattened myoepithelial cells.

上皮细胞的内层，腺体的分泌部，被一层扁平的肌上皮细胞包绕着。

The changes of actin expression in atypical hyperplasia are possibly correlated with carcinogenesis of breast cancer, and myoepithelial cells may play a role in carcinogenesis of breast cancer.

乳腺不典型增生时肌动蛋白表达的变化可能与乳腺癌的发生有关，肌上皮细胞可能参与了乳腺癌的发生。

Methods SP immunohistochemistry was used to detect actin expression in normal breast tissue, grade Ⅰ,Ⅱ and Ⅲ atypical hyperplasia and breast cancer. Electromicroscopy was used to observe the changes of ultrastructure of myoepithelial cells.

用免疫组化SP法分别检测正常乳腺组织、Ⅰ级一般性增生和Ⅱ级、Ⅲ级不典型增生乳腺组织及乳腺癌组织中肌动蛋白的表达情况，并用电镜观察肌上皮细胞超微结构的变化。

Results:There is a close positive correlation between myoepithelial cell differentiation and glandular cell maturation and the ratio of myoepithelial cells to glandular endpieces area was decreased.

结果：实验结果提示，小鼠泪腺肌上皮细胞从出现到成熟的形态变化，与腺细胞内的分泌颗粒从出现到增多是同期发育的，泪腺腺房与肌上皮细胞的面积比率呈减小趋势。

I didn't watch TV last night, because it .

昨晚我没有看电视，因为电视机坏了。

Since this year, in a lot of villages of Beijing, TV of elevator liquid crystal was removed.

今年以来，在北京的很多小区里，电梯液晶电视被撤了下来。