肉芽肿

Classically, c-ANCA is associated with Wegener's granulomatosis; p-ANCA is associated with microscopic polyangiitis and focal necrotising and crescentic glomerulonephritis .

古典和 c -抗体与韦格纳肉芽肿病；型ANCA 与显微镜下多血管炎和协调坏死和新月体肾炎。

Materials and MethodsMaterials; 10% formalin fixed, paraffin -embedded tissue samples, including ; MF 59 cases, neurodermatitis 20 cases, chronic eczema 20 cases, parap-soriasis 40 cases, all taken from laboratory of dermatopathology in No.

材料和方法实验材料：来自中国医科大学附属第一床医院皮肤科病理室，10%福尔马林固定、石蜡包埋组织标本：蕈样肉芽肿59例、神经性皮炎20例、慢性湿疹20例、副银屑病40例、临床及病理都符合其疾病的诊断标准；正常皮肤组织标本20例：来自中国医科大学附属第一医院整形外科手术切除的正常人正常皮肤。

Results Qidan Granules could relieve the pain caused by glacial acetic acid and heat stimuli; significantly inhibit the oxytocin-induced dysmenorrheal in mice; It also showed obvious inhibitory effects on the increased capillary permeability induced by glacial acetic acid, carrageen-induced toe edema in rats and dimethylbenzene-induced ear swelling in mice, and cotton pellet-induced granuloma formation in rats. It could also significantly inhibit oxytocin-induced dysmenorrhea in mice.

结果 奇丹颗粒能明显抑制乙酸和热刺激所致的小鼠疼痛反应；对缩宫素所致实验性痛经小鼠具有良好的镇痛作用，对乙酸所致小鼠腹腔毛细血管通透性增高以及大鼠角叉菜胶足趾肿胀、二甲苯所致小鼠耳廓肿胀、大鼠棉球肉芽肿等急慢性炎症模型均有明显抑制作用。

The mice inoculated with Coxiella burnetii intrana- sally developed interstitial pneumonia,while the primary pathological changes of mice inoculated intraperitoneally are granulomas in spleen and liver.2.The pathological changes became more severe followed the dosage increasing.3.Coxiella burnetii can be detected in spleen and liver at day 2 after inoculation.the lesion became more and more serious from day 2 to day 12.The characteristic changes were observed at day 7,and recovered at day 14. 4.The reticuloendothelial system are main target of Coxiella burnetii.The pathogen was detected in cytoplasm of monocyte -macrophages of spleen, liver, lung, and endothelioid cells of blood vessel. 5. Coxiella burnetii can be found in macrophages lysosomes by electron microscopy. Most of them are round or rod, and polymorphic shape can also be observed in different size.

结果：1、通过不同感染途径的实验证实，滴鼻感染的小鼠主要表现为间质性肺炎，而腹腔注射感染小鼠则以脾脏、肝脏肉芽肿为主要病变。2、通过不同剂量的感染实验发现，随着感染Q热立克次体剂量的加大，动物病变愈加严重。3、通过感染后不同时间的动态病理学观察发现，在腹腔注射后第2d的脾和肝脏即可发现病原体，主要脏器的病理变化从第2d到第12d逐渐加重，第7d动物的病变最典型，至感染后14d动物的受损器官已开始出现修复性变化。4、 Q热立克次体主要侵害机体的网状内皮系统，在感染小鼠的肝、脾、肺和外周血管单核巨噬细胞以及血管内皮细胞胞浆中查见病原体。5、透射电镜观察可见Q热立克次体主要位于巨噬细胞吞噬溶酶体内，呈多形性，多见圆形和杆状，大小不一。

Objective To explore the diagnosis and treatment of gastric eosinophilic granuloma.

目的 进一步探讨胃嗜酸性肉芽肿的诊断与治疗。

Objective:To further understand clinical features,pathology,diagnosis and therapy of the skull eosinophilic granudoma.

目的 ：探讨颅骨嗜酸性肉芽肿的临床表现、病理改变和诊断与治疗的方法。

MethodsClinical data of 22 patients with gastrointestinal eosinophilic granuloma from Jan.

方法对1980年1月至2004年9月收治的22例胃肠道嗜酸性肉芽肿的临床资料进行回顾性分析。

Results:In 111 cases of epididymal disease there were:epididymal tumor 11 cases,granuloma 28 cases,cyst 24 cases,tuberculosis 21 cases,and cronic inflammation 27 cases.

结果：111例病人中附睾肿瘤11例、精子肉芽肿28例、囊肿24例、结核21例、慢性炎症27例。

Epithelioid granuloma detection increased with the number of endoscopic sampling procedures; sampling site had no influence.

检测到的上皮样肉芽肿随内镜下取样操作次数的增多而增多，不受取样部位的影响。

Etiologically, the commom cancerogens include: lowered power of resistance, weakened functions of spleen and stomach, emotional disturbance such as grief, worry and anger, long term mechanical and inflammatory irritation, granuloma caused by the accumulation of schistosome ova, malignant change of polyp from chronic adenoma, chronic ulcer and anal fistula.

根据病因学，普通致癌物包括：低功率电阻，脾胃功能减弱，情绪困扰如悲伤、焦虑和愤怒，长期力学和炎症刺激，血吸虫卵积聚引起的肉芽肿，慢性腺瘤中息肉的恶性变化，慢性溃疡和肛瘘。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。