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肉桂酸苄酯

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Results Benzyl cinnamate, benzyl benzoate and borneol were found in vitro of rabbits, 2-hydroxy-methyl benzoate and borneol were found in vivo of rabbits.

结果 体外药物成分含有肉桂酸苄醋、苯甲酸苄酯、冰片等;体内药物成分含有2-羟基苯甲酸甲酯、冰片等。

The method of catalytic synthesis of benzyl cinnamate with hexadecyl trimethyl ammonium chloride as phase transfer catalyst is studied.

以十六烷基三甲基氯化铵为相转移催化剂催化合成肉桂酸苄酯,考察了催化剂、温度、时间和物料配比等因素对反应的影响。

Benzyl cinnamate ; phase transfer catalyst ; synthesis

肉桂酸苄酯;相转移催化剂;合成

Borneol play a role in blood with an original form, benzyl cinnamate and benzyl bcnzoate were metabolized into 2-hydroxy-methyl benzoate to produce marked effect.

冰片以原型药物形式入血产生疗效,肉桂酸苄醋、苯甲酸苄酯被转为2-羟基苯甲酸甲酯的代谢产物发挥作用。

After esterification, the ethyl-2-chloro-3-phenylpropionate reacts with diethyl malonate under the catalysis of sodium ethylate, and we obtain the corresponding triethyl ester. The-benzylsuccinic acid is formed by the triethyl ester reacting with concentrate hydrochloric acid and taking place hydrolyzation and decarboxylation reaction at the same time. In order to avoid the formation of cinnamic acid, the sodium ethylate and diethyl malonate must be react sufficiently. The course has simple operation, inexpensive materials and better yield.

具体制备工艺为:首先以L-苯丙氨酸为原料采用重氮化方法得到-2-氯-3-苯基丙酸,再经酯化得到-2-氯-3-苯基丙酸乙酯后在乙醇钠催化作用下和丙二酸二乙酯缩合,发生SN2反应,得到相应的三乙酯,然后经水解和脱羧,得到-苄基丁二酸;在实验中乙醇钠要和丙二酸二乙酯充分反应,避免生成肉桂酸乙酯;该过程操作简单,原料便宜,产率较高,总收率可达到26.8%。

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