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Over the past year, the group evaluated the seven-year follow-up results of therapeutic effects of all-trans retinoic acid and arsenic trioxide (As2O3) combined treatment in newly diagnosed acute promyelocytic leukemia. We also studied the mechanism of therapeutic effects of Imatinib and As4S4 combined treatment in CML cell line and animal model. These two papers were published on PNAS.

过去的一年中,本课题组总结完成了全反式维甲酸和三氧化二砷联合治疗初发急性早幼粒细胞白血病的七年临床随访资料的疗效评估;在慢性粒细胞性白血病,完成了应用As4S4和STI571联合治疗作用的细胞、分子和整体动物水平的机制研究,这两部分工作均已发表于PNAS。

Objective To investigate the effect of sodium arsenite combined with cigarette smoke solution on expression of Bcl-2 and Bax in rat lymphocytes and study their interaction.

目的 研究亚砷酸钠和香烟烟气溶液联合作用对凋亡相关基因Bcl-2和Bax表达的影响,并探讨它们对这2种基因表达的影响是否存在交互作用。

Combined effects of BaP and TBT to antioxidant system were complicated, and antagonistic interactions were dominating.

BaP和TBT对抗氧化体系指标产生了复杂的联合作用结果,主要表现为拮抗作用。

MATERIALS AND METHODS: Cytotoxicity of the drugs was measured by MTT assay. The coefficient of drug interaction was used to analyze the synergistical suppressive effect of drug combination.

材料与方法:采用MTT法测定不同浓度氯化镉和顺铂对人肝癌细胞SMMC-7721增殖的抑制作用;应用两药相互作用指数进行联合作用分析。

Objective To identify active compounds which have antifungal activity or can work synergistically with fluconazole on Candida albicans.

目的寻找对白色念珠菌具有抗真菌作用或与氟康唑具有联合抗真菌作用的活性化合物。

There was overexpression of OPG in human osteosarcoma. The expression of OPG may have a close correlation with the ossifying of osteosarcoma.

第二部分:TRAIL及RANKL联合治疗骨肉瘤的试验研究目的:探讨TRAIL与RANKL联合应用的对人骨肉瘤细胞的杀伤作用。

On the other hand, the beneficial effects of the ACE or ARB drugs may be more reasonable and a better clinical judgment for combining therapy to achieve clinical protection as we have seen in AVOID, cardio-protection as we have seen in ALAY, and protection for heart failure as we have seen in ALOFT.

另一方面, ACEI或者ARB类药物的有益效应可能更合理,是更好的联合治疗的选择,从而获得我们在AVOID试验中所见到的临床保护作用、在ALAY试验中所见到的心脏保护作用、以及在ALOFT试验中所见到的心衰保护作用。

Corpus vertebrae and arcus vertebrae were modeled using eight-noded brick elements. Using the material properties from literature, the 2885-finite element model was exercised under different corrective loads such as forces of distraction, compression and rotation, etc.

分别研究纵向撑开力、横向矫形力及旋转力、压缩力的作用,并进行各类矫形力单独作用及联合作用时的矫形效果比较,同时对三维有限元法在脊柱畸形矫形中的应用价值作相关分析。

ECOD activity was induced by BaP, TBT or their mixture at high concentrations after 50 days exposure, and it is advisable to use ECOD activity as a biomarker to assess severe PAHs or TBT pollution. UDPGT was analyzed as phase II enzyme.

ECOD活性在BaP、TBT或者二者的联合作用下主要表现出被诱导效应,也能反映出高浓度的BaP和TBT联合污染情况,可以作为高污染环境中的生物标志物参考指标。

The plastic go down the hopper smoothly and is gripped by the thread of the screw. It is forced to go toward the direction of the gear end along with the rotation of the screw. A mechanical transferring process is formed. During the running of the plastic from the feed port to gear end, a high pressure is formed in the process of plastic curing due to the gradual decreasing of the thread depth and the resistance of filter gauze, splitter plate and gear end. The high pressure helps to press the raw material and improve its heat conductivity performance and the quick melting of the plastic, at the same time, the gradual increasing pressure can help the gas which is among material particles exhausted from the air holes.

在压力升高的同时,塑料一方面被外部加热,另一方面塑料本身在压缩、剪切、搅拌的运动过程中,由于内磨擦力也产生了大量的热,在外力和内力的联合作用下,塑料温度逐渐增高,其物理状态也经历了玻璃态--高弹态--粘流态的变化,一般地说来,在加料段中主要是玻璃态,在螺杆螺纹逐渐减少的中间部分压缩段中,物料主要处于高弹状态,同时也逐渐的熔融,而物料到压缩段后部和化段作用处于粘流态了,这时我们称塑料已完全塑化了,由螺杆推力作用将塑化的塑料定压定量的从机头中挤出。

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