联合作用的

It is of great significance of detecting aggregated expression of three drug resistance protein for the guiding clinical chemotherapy.

联合检测这3个耐药蛋白的表达，对指导临床化疗有一定作用。

Objective:To investigate the therapeutic effect of inhaled corticosteroid combined with longacting β2 agonist on patients with chronic obstructive pulmonary disease.

目的：探讨联合吸入糖皮质激素与长效β2激动剂对慢性阻塞性肺疾病的治疗作用。

Neutralizing potency of the patent recombinant anti-rabies virus McAbs, SO57 and SOJB,have been investigated broadly to different rabies virus strains in various animal models.100% Chinese Hamsters could be protected by 100IU/kg SO57 against China prevalent street rabies virus named SBD.We firstly established the mouse model to simulate human postexposure prophylaxis by rabies virus and found SO57 had the same function with HRIG against CVS or three China typical street rabies viruses.However,HRIG could not 100% protect the mice challenged with SBD street virus,rabies virus vaccine alone could not save life from rabies virus infection.The cocktail containing SOJB and SO57(1:1) did not do better than SO57 alone.

用不同的动物模型研究了具有专利的重组人抗狂犬病病毒单克隆抗体SO57、SOJB对不同狂犬病病毒株的中和作用，100IU/kg的SO57能100%保护被中国街毒株SBD攻击的中国仓鼠；首次用小鼠模型模拟人体被狂犬病病毒攻击后的治疗情况，在小鼠被CVS及中国街毒代表株攻击后，SO57与HRIG具有相近的对小鼠的暴露后保护作用；同时结果显示HRIG对SBD株攻击的保护率不能到达100%，仅使用疫苗是不能对感染病毒的小鼠百分之百的保护；SOJB与SO57 1：1联合使用未显示比SO57单独使用更好的保护效果。

The joint toxicity was evaluated by different methods, including toxicity unit,additive index, similarity parameter and mixtures toxicity index. The results show that the binary joint effects of phenol and toluol mixed with SDS are synergistic, while the binary joint effect of SDS and nitrobenzene is antagonistic. The environment risk of some compounds will be enhanced because of the joint of SDS.

研究结果表明： 4种不同的评价方法对SDS与取代芳烃苯酚、甲苯和硝基苯的联合效应评价结果具有较好的一致性，即SDS与苯酚、甲苯的二元混合体系的毒性表现为不同程度的协同作用，而与硝基苯则表现为弱拮抗作用；对环境存在风险性的阴离子表面活性剂SDS，当与一些有毒有害物质共存时会增加该类物质的环境风险性。

Simvastatin may exert its function to prevent allograftangiopathy by the mechanism of cholesterol-lowering, the increase expression ofeNOS and secretion of NO, direct anti-inflammatory effect, commissural inhibitionwith cyclosporine on MHC-II and CD4~+ T cells.

他汀类药物可能通过降低血胆固醇水平、促进eNOS 的表达并增加NO 的分泌、直接的抗炎作用、与环孢素联合抑制MHC-II 的表达和T 淋巴细胞的活化增殖等机制来对抗同种异体血管硬化的作用。

In vitro, studies demonstrated that new retinoids in combination with IFN-γ could induce monoblastic leukemia cells to differentiate and inhibit their proliferention.

本文研究了NB4细胞株和新鲜急性早幼粒白血病细胞在新维甲类R9158、R8923、R9123和YS904012作用后的生物学特性变化；并且在初筛的基础上，选用R9158和YS904012与IFN-γ联合使用，研究对U937细胞株和6例原代单核系白血病细胞的增殖分化作用。

However the co-administration of bromocriptine (10 mg/kg) and baclofen (1.0 mg/kg) can inhibit the withdrawal response. The results showed that the two receptors synergized and effectively inhibited the naloxone-induced withdrawal syndromes.

当无抑制作用剂量的溴隐亭(10mg/kg)和巴氯芬(1.0mg/kg)联合应用时能够明显抑制小鼠的戒断症状，说明此二受体在吗啡成瘾后戒断期间功能上具有协同作用，能够很好地抑制纳络酮诱导的成瘾小鼠跳跃症状。

The expression of NF-κB protein is related to progression of the advanced gastric carcinoma. The re-expression of E-cadherin and β-catenin in cancer cells of metastatic lymph nodes from advanced gastric carcinoma existed, and which was closely correlated with tumor grade, may play an important role in the re-growth of cancer cells in metastatic foci.

NF-κB的表达与进展期胃癌的发展过程密切相关，E-cad及β-catenin在转移淋巴结中的再表达是进展胃癌发生的重要事件，二者协同发挥作用，并对癌细胞在转移灶中的聚集生长起重要作用，联合评价其功能具有更重要的临床意义。

The re-expression of α-and β-catenin in cancerous cells of metastatic lymph nodes from advanced gastric carcinoma is existent. and which correlates with tumor grade may play an important role in the re-growth of cancer cells in metastatic foci.

及β-catenin在转移淋巴结中的再表达是进展期胃癌发生的重要事件，二者协同发挥作用，并对癌细胞在转移灶中的聚集生长起重要作用，联合评价其功能具有更重要临床意义。

Ethambutol is a first-line drug used for antituberculosis therapy. It is often used in combination with isoniazid, rifampin, pyrazinamide, and streptomycin. The action of EMB in antituberculosis mechanism is the destruction of cell wall of tubercle bacilli via binding the target molecule -- arabinosyl transferases. These enzymes are involved in the polymerization of the cell wall arabinan. Inhibition of arabinan synthesis by EMB results in the accumulation of mycolic acids, leading to cell death.The EMB-resistance of MTB is involved with the mutation of emb operon or the over expression of emb operon.

乙胺丁醇是和异烟肼、利福平、链霉素、吡嗪酰胺联合治疗结核病的一线抗结核药物，EMB对结核分枝杆菌的作用机制与分枝杆菌胞壁结构破坏有关，主要作用于靶分子阿拉伯糖基转移酶，抑制了阿拉伯糖基聚合入阿拉伯半乳聚糖，从而影响细胞壁分枝菌酸-阿拉伯半乳聚糖-肽聚糖复合物的形成，导致菌细胞的死亡。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。