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Combinative toxicity of the mixture falls into the category of additive effect.

微囊藻毒素LR、黄曲霉毒素B1和伏马菌素B1对Hep G2的联合毒作用类型为相加作用。

Objective: The aim of this study was to observe the protective function of trehalose and phosphate at -80℃on human apheresis platelets, and to realize the long-term(3 months) protective function of this platelet storage solution.

目的观察-80℃条件下海藻糖联合磷酸盐对人单采血小板的保护作用,并了解海藻糖联合磷酸盐对血小板的长期保存(3个月)效果。

With an orthogonal experiment design , the telomerase inhibitors [azidothymidine , AZT 300 mg/ and lamivudine 150 mg/, per os , bid ,×2 weeks ] and X2irradiation [ total dose 10 Gy (2 Gy ×5) in 1 week ] were used to treat BALB/ c mice carrying breast cancer MA782 for evaluating the influence on peripheral blood cells , bone marrow nucleated cells and telomerase activity.

为了探讨端粒酶抑制剂联合X 线照射对荷瘤小鼠的骨髓抑制作用,采用正交实验设计,应用端粒酶抑制剂[AZT 300 mg/, lamivudine 150 mg/ ]联合X 线照射(2 Gy ×5次/ 1 周)处理移植性乳腺癌(MA782 )小鼠,观察其对骨髓有核细胞、外周血像及骨髓端粒酶活性的影响。

The effect of growth and oil degradation rate varied with species of plant when inoculated ECM fungi combined with specific bacteria or fungi, but both decreased compare with single inoculation when combined with azotobacter.

外生菌根真菌与专性降解菌联合接种对植物生长的促进作用及对矿物油的降解效果因植物而异,与固氮菌联合接种则抑制植物生长,降解效果低于单独接种。

Changdong" showed a noticeable enhancive effect when it was co-administrated with other anti-tumor agents or when it was co-applied with radiotherapy. The action mechanism study showed that an apparent cytotoxic effect of "Changdong" on ten tumor strains in vitro with a quantity-effect relationship was observed. Immunity experiment showed that "Changdong" could induce proliferation of spleen lymphocyte in mice bearing tumor and could improve NK cell" s activity, whereas has no impact on IL-2" s reproduction. It was also noticed that "Changdong" could induce human liver cancer QGY" s apoptosis in vitro, and it happened mainly on G0-G1 phase.

结果:"长动"对小鼠移植瘤模型和人体肿瘤裸鼠异种移植均有明显抑制作用,量效关系明显:"长动"与放疗和化疗分别联合应用有明显的增效作用:作用机制研究结果:细胞毒性试验研究表明"长动"在体外对10株肿瘤细胞有明显的细胞毒性作用,量效关系明显;免疫学试验表明"长动"可以诱导荷瘤小鼠的脾淋巴细胞增殖,增强NK细胞的活性,对IL-2的产生无明显影响;"长动"在体外可明显诱导人体肝癌QGY细胞凋亡,使细胞阻滞于G0-G1期。

FPG,FINS,TG,TC,LDL-C of Model group were increased,ISI were decreased . The expression of PAI-1mRNA of adipose tissues was increased significantly (.2)Compairing with model group,the berberine and taurine group and combine group could significantly increase insulin sensitivity, decrease the expression of PAI-1mRNA in epiploon adipose tissue. The parameters mentioned above in combine group was better than other groups.

与正常组比较,模型组体重增加,血清 FPG、FINS、TG、TC 、LDL-C 升高,ISI 降低,血清中 FFA 浓度增加,内脏脂肪细胞肥大,脂肪组织中 PAI-1 mRNA 表达显著增加;(2)与模型组比,联合组、黄连素组、牛磺酸组、二甲双胍组均出现 ISI 升高和 PAI-1mRNA 表达减少,二者的协同作用优于单独作用,并优于二甲双胍组。

The Chinese compound prescription can improve the bone formation and prevent bone loss via inhibiting bone absorption and improving ossify,bone mineral deposition and mineralization as well as increasing BMD,which leads to prevention and treatment of bone loss.

中药复方能明显促进骨形成作用,有效抑制骨吸收作用,减弱溶骨过程从而促进骨矿盐的沉积和矿化,增强BMD而达到防治骨丢失的作用;有效的防护和治疗失重性骨丢失采取联合措施很有必要。

Objective To investigate the prevention of simvastain and cyclosporine respectivelyand their associated effect on allograft angiopathy in rats, then discuss their potentialmechanism of action and possible synergistic action.

目的观察辛伐他汀和环孢素A单独用药和联合用药对大鼠同种异体血管病的预防作用,并探讨其可能的作用机制及二者之间有无协同作用。

Objective: The purpose of this study was to determine whether potentiating induction of apoptosis in cervical cancer cell line SiHa lacking full-length FHIT transcripts and endogenous FHIT protein by cisplatin via introduction of extopic FHIT gene. Meanwhile, to investigate if the apoptosis of the SiHa cells is induced by FHIT gene.

目的 验证外源性脆性组氨酸三联体抑癌基因的导入是否诱导宫颈癌SiHa细胞凋亡,观察FHIT导入与顺铂联合应用诱导宫颈癌SiHa细胞凋亡的作用是否有协同效应,为联合基因治疗和化疗药物治疗人宫颈癌提供实验依据。

Compared with the single pollution, the eco-toxicity of compound pollution of As+Cd and Cu+Cd becomes stronger, which preemie a synergistic effect, as far as the lethal concentration to the cell of duckweed's lemma is concerned; As+Cu and As+Cu+Cd is inclined to an antagonistic effect of which the eco-toxicity of compound pollution becomes weaker.

与单一污染相比,As+Cd和Cu+Cd复合污染对浮萍叶绿素毒性增强,表现为协同作用,加强了对浮萍叶细胞的伤害;而As+Cu和As+Cu+Cd复合污染对叶绿素联合毒性作用趋向于毒性减少的拮抗作用。

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