联合作用

Objective: The aim of this study was to observe the protective function of trehalose and phosphate at -80℃on human apheresis platelets, and to realize the long-term(3 months) protective function of this platelet storage solution.

目的观察-80℃条件下海藻糖联合磷酸盐对人单采血小板的保护作用，并了解海藻糖联合磷酸盐对血小板的长期保存(3个月)效果。

Over the past year, the group evaluated the seven-year follow-up results of therapeutic effects of all-trans retinoic acid and arsenic trioxide (As2O3) combined treatment in newly diagnosed acute promyelocytic leukemia. We also studied the mechanism of therapeutic effects of Imatinib and As4S4 combined treatment in CML cell line and animal model. These two papers were published on PNAS.

过去的一年中，本课题组总结完成了全反式维甲酸和三氧化二砷联合治疗初发急性早幼粒细胞白血病的七年临床随访资料的疗效评估；在慢性粒细胞性白血病，完成了应用As4S4和STI571联合治疗作用的细胞、分子和整体动物水平的机制研究，这两部分工作均已发表于PNAS。

With an orthogonal experiment design , the telomerase inhibitors [azidothymidine , AZT 300 mg/ and lamivudine 150 mg/, per os , bid ,×2 weeks ] and X2irradiation [ total dose 10 Gy (2 Gy ×5) in 1 week ] were used to treat BALB/ c mice carrying breast cancer MA782 for evaluating the influence on peripheral blood cells , bone marrow nucleated cells and telomerase activity.

为了探讨端粒酶抑制剂联合X 线照射对荷瘤小鼠的骨髓抑制作用，采用正交实验设计，应用端粒酶抑制剂[AZT 300 mg/， lamivudine 150 mg/ ]联合X 线照射(2 Gy ×5次/ 1 周)处理移植性乳腺癌(MA782 )小鼠，观察其对骨髓有核细胞、外周血像及骨髓端粒酶活性的影响。

The effect of growth and oil degradation rate varied with species of plant when inoculated ECM fungi combined with specific bacteria or fungi, but both decreased compare with single inoculation when combined with azotobacter.

外生菌根真菌与专性降解菌联合接种对植物生长的促进作用及对矿物油的降解效果因植物而异，与固氮菌联合接种则抑制植物生长，降解效果低于单独接种。

MICs of the combination of cefoperazone or ceftazidime and levofloxacin were determined by the microdilution chequer board technique,interpretation of the results was made by calculation of FIC.

结果：头孢哌酮、头孢他啶和左氧氟沙星联合用药对铜绿假单胞菌的体外抗菌协同作用为35 5%～38 7％，相加作用为41 9%～45 2％，无关作用为16 1%～22 6％，无拮抗效应。

The Chinese compound prescription can improve the bone formation and prevent bone loss via inhibiting bone absorption and improving ossify,bone mineral deposition and mineralization as well as increasing BMD,which leads to prevention and treatment of bone loss.

中药复方能明显促进骨形成作用，有效抑制骨吸收作用，减弱溶骨过程从而促进骨矿盐的沉积和矿化，增强BMD而达到防治骨丢失的作用；有效的防护和治疗失重性骨丢失采取联合措施很有必要。

Results DOX pre-conditioning and IP significantly decreased serum AST,ALT and LDH,furthermore interaction of DOX preconditioning and IP had statistical significance and associating application of the two methods decrease serum AST,ALT and LDH to a lower level.IP significantly decreased plasma ET and serum TNF-α;DOX and IP significantly increased serum NO;DOX preconditioning improved the expression of HSP70in liver.

结果 阿霉素预处理、缺血预处理、阿霉素+缺血联合预处理能明显抑制AST、ALT、LDH水平升高，其中以阿霉素+缺血联合预处理作用最显著；缺血预处理能显著降低ET、TNF-α水平；阿霉素预处理和缺血预处理使NO显著升高；阿霉素预处理能使肝细胞HSP70显著增加。

(1)The levels of MCP-1 and VEGF'levels was significant increased in CHD patients,Compared with controls, It was implicated that they might take part in the actions of informing atherosderotic plaques;(2)The serum level of MCP-1 and VEGF were elavated step by stey among the group of controls、SAP、UAP、AMI, It was thought they might develop the matter on the stability of atherosderotic plaques;(3)The serum level of MCP-1 and VEGF were positive correlated with 7-TIMI risk score, It prompt that MCP-1 and VEGF was the reactiveness markers of coronary artery process ,and developed the risk to major acute cardiac events.

(1)血清MCP-1、VEGF水平在冠心病患者中显著升高，提示MCP-1、VEGF可能在促进冠状动脉粥样硬化斑块形成的过程中起重要作用；(2)血清MCP-1、VEGF水平在对照组、各冠心病亚组(SAP、UAP、AMI组)之间逐级升高，提示MCP-1、VEGF可能增加了冠状动脉粥样硬化斑块的不稳定性；(3)联合检测MCP-1、VEGF的灵敏度\特异度上升，证明临床上联合检测二者血清指标意义大；并且血清MCP-1、VEGF水平和7-TIMI积分呈正相关性，7-TIMI积分高的患者血清MCP-1、VEGF水平也高，说明它们能作为冠脉病变的活动性标志物，可能成为评价主要心血管恶性事件的危险性的相关指标。

Objective To investigate the prevention of simvastain and cyclosporine respectivelyand their associated effect on allograft angiopathy in rats, then discuss their potentialmechanism of action and possible synergistic action.

目的观察辛伐他汀和环孢素A单独用药和联合用药对大鼠同种异体血管病的预防作用，并探讨其可能的作用机制及二者之间有无协同作用。

This topic intends to set up the animal model of apositia with the function of central inhibition to investigate the pharmacological effect of Shanzha Maiya granula and research the functional mechanism of the Chinese medicines for invigorating spleen to promote digestion in view of braingut petide-appestat.

CLAIRE报道LP50μg/kg单独腹腔注射可以降低大鼠进食量，LP 50μg/kg和8～16μg/kgCCK联合腹腔注射效果更佳，两者联合腹腔注射后与LP单独腹腔注射后大鼠食量比较差异有统计学意义，Scott等报道第三脑室注射LP 7μg/kg和腹腔注射CCK 2μg/kg都有降低食欲的作用。

For a big chunk of credit-card losses; the number of filings (and thus charge-off rates) would be rising again, whether

年美国个人破产法的一个改动使得破产登记急速下降，而后引起了信用卡大规模的亏损。

Eph. 4:23 And that you be renewed in the spirit of your mind

弗四23 而在你们心思的灵里得以更新