耐药的

This work establishes a radical-based molecular mechanism whereby sublethal levels of antibiotics can lead to multidrug resistance, which has important implications for the widespread use and misuse of antibiotics.

这给我们构建了一个激进的分子机制，而抗生素的亚致死水平可以导致对多种药物的耐药，这对抗生素的广泛和滥用有重要的提示。

A number of nucleic acid repair genes such as excision repair cross-complementing gene 1(ERCC1) and human xeroderma pigmentosum gene D(XPD/ERCC2),the level descent may be susceptible factors to one or certain kinds of tumors; but if these genes′ level are higher,the ability to repair damage and chemotherapy-induced genetic damage will be enhanced,it may be resistance to chemotherapeutic drugs.

一些核酸修复基因，如切除修复交叉互补基因1(ERCC1)及人类着色性干皮病基因D(XPD/ERCC2)的水平下降，可能会成为某种或某几种肿瘤的易感因素；但如果此种基因的水平较高，修复损伤的能力提高，对化疗药物所致基因损伤的修复能力也就增强了，那么可能对化疗药物产生耐药现象。

And then the expressing level of AcrAB was detected by Western blotting. The results indicated that the level of resistance to fluoroquinolones of isolates appeared closely correlated with substitution in GyrA and ParC, but expressing level of AcrAB had not significant changes.

序列分析及AcrA的Western blotting检测结果表明，临床分离的鸡大肠杆菌对喹诺酮类药物的耐药水平与GyrA和ParC的突变密切相关，而AcrAB外输泵的表达水平无显著变化。

Some gene mutations of rob gene of the 5 E.coli isolates were related to animal species and to the level of drug resistance by affecting on the expression level of AcrAB efflux pump.

不同源性大肠杆菌的rob基因的核苷酸序列与其动物源性有关，该基因的核苷酸序列的个别突变位点可能影响AcrAB外输泵的表达水平，进而影响其多重耐药水平。

Background: Infectious disease is still the most prevalent disease in the world, which consists variety of new challenges, including chronic infection, arthrosclerosis induced by infection, infection after transplantation, infection due to the resistance of bacteria, et al.

尤其应该指出的是，在当前医学治疗中普遍存在的抗生素泛滥应用的现象，使得尽管抗生素不断推陈出新，仍然解决不了细菌的耐药问题，反而加大了抗菌素的毒副作用。

The strains of imipenem-susceptible Pseudomonas aeruginosa mainly come from respiratory tract infections and wound infections, and the susceptibility for most antibiotics is high. As a kind of strong derivant, mipenem can make Pseudomonas aeruginosa induce resistance.

亚胺培南敏感的铜绿假单胞菌主要来源于呼吸内科和老年内科的呼吸道感染，其次是骨科的各种伤口感染，对所有抗生素的敏感率均比较高，亚胺培南是一种较强的诱导剂，可以使铜绿假单胞菌产生诱导耐药。

Producing AmpC and ESBLs are higher than that to Klebsiella producing AmpC but nonproducing ESBLs. The genotypes of Klebsiella producing AmpC are mainly DHA type. Imipenem is the first choice of the antibiotics against Klebsiella carrying 2～6 kinds of resistance genes in clinic.

克雷伯菌产AmpC酶和同时产ESBLs的耐药性比单纯产AmpC酶的耐药性更高、更显著；肺炎克雷伯菌产AmpC酶的主要基因型为DHA，对同时存在2～6种不同类型耐药基因的克雷伯菌，碳青霉烯类药物亚胺培南的体外活性最好。

Contrasting with the control strain of Shigella sonnei, the test strain could be higher antibiotics rate, and it could not be agglutinated by several anti-sera to Shigella sonnei, which were in the period of validity, but the control strain could be well agglutinated.

检测试验菌株的生化特性和对抗生素的敏感性，以及用多种批号的诊断血清进行凝集试验。结果：具有典型的宋内氏志贺菌的生化特性；与对照菌相比，有较高抗生素耐药性，对复方新诺明等多种抗生素耐药。

Over the recent two decades, the emergence of more and more drug-resistant HSV strains has been associated with the widespread and frequent use of antiviral drug for treatment, suppressive therapy and prophylaxis of HSV infection, maturating of organ transplantation, and the increasing of HIV infection.

随着核苷类抗病毒药的广泛使用和器官移植技术的成熟，以及HIV发病率的增加，国外关于HSV对抗疱疹病毒药的敏感性降低甚至出现耐药株的报道逐渐增多。

The result indicated that there is little difference between the two pig farms,though there are much difference in the using of antibiotic.It is prompted that there are some disciplinarians in the form of antibiotic resistance.

结果显示，从用药习惯和用药频率存在较大差异的新旧2个猪场分离到的大肠杆菌对这些抗生素的耐药情况比较接近，对大部分抗生素仅为程度上的差别。

She gently rebuff ed him, but agreed that they could be friends

她婉言拒绝了，但同意作为朋友相处。

If in the penal farm, you were sure to be criticized.

要是在劳改农场，你等着挨绳子吧！