耐药的

RESULTS Anti-infection medicine and FQNs uses the trend that the medicine amount of money shares to always have with the medicine amount of money percentage to rise year by year,during the period 2000~2003,in 2004 hereafter lower gradually.

近年来，对氟喹诺酮类药物耐药的细菌日益增多，在几乎所有医院内感染致病菌中均发现有氟喹诺酮耐药株[1]，已严重影响其疗效和临床应用[2]。

Obvious difference was showed in the expression level of CDR1 gene between azole resistant and sensitive isolate.

1。观察到目前肾移植患者人群白念珠菌分离株可能存在唑类耐药，并发现唑类耐药的发生与分离部位没有明显相关。

ESBLs producing strains were more resistant to penicillins and cep...

结论ESBLs是细菌对青霉素类和头孢类抗菌药物耐药的重要机制，及时监测产ESBLs菌的发生率及其耐药趋势以指导临床用药至关重要。

Objective To investigate DNR subcellular distribution in the non-P-glycoprotein-mediated multidrug-resistant cell line HL-60/ADR and its relation to multidrug resistance.

目的 了解化疗药物在非Pgp耐药细胞株HL-60/ADR细胞内的异常分布与耐药的关系。

aim: to study the expression and significance of p glycoprotein in the development of multidrug resistance in breast cancer.

目的：研究乳腺癌原发性耐药过程中p糖蛋白（p glycoprotein， p gp）的表达特征，初步探讨乳腺癌原发性耐药的发生机制。

ObjectiveTo explore the reversal effect and mechanism of lobeline on the multidrug-resistance of human breast cancer cells MCF-7/ADM.

目的：探讨哌啶生物碱洛贝林对人乳腺癌多药耐药细胞株MCF-7/ADM耐药的逆转作用及其分子机制。

Objective To establish gemcitabine-resistant pancreatic cancer cell strain and study the role of thioredoxin reductase in drug-resistant process.

目的 建立对吉西他宾耐药的胰腺癌细胞株，探讨硫氧还蛋白还原酶在耐药过程中的作用。

AIM: To study the multidrug resistancereversing effect of Chinese drug Thallus Laminariae PE on human endometrial cancer cell line BMDC1 in vitro and its underlying mechanism.

目的：研究昆布提取物在体外对耐药细胞BMDC1的逆转作用，探讨其逆转肿瘤多药耐药的机制。

These findings identify a previously undescribed resistance mechanism to FEC treatment and suggest that antistromal agents may offer new ways to overcome resistance to chemotherapy.

这些调查结果发现了以前未曾被描述的对FEC治疗耐药的机制，提示抗间质药物可提供新的方法来克服化疗耐药这一难题。

New antifungal agents have been developed over the past years based on the discovery of many new target sites of Candida albicands. For example, Echinocandins, aiming at the cell wall of Candida albicands, showed strong antifungal activities to fluconazole resistant candidas and fungal biofilm. Moreover, because β-glucan synthase does not exist on the cell membrane of mammalian cells, Echinocandins has a low toxicity and a promising clinical future. Though the mechanism of Histatin is not clear, it has strong activity not only on candida resistant of polyene and azole, but also to Candida parapsilosis, Candida krusei and Cry ptococcus neoformans. Berberine and Ocimum gratissimum L. were also found to have prominent anti-fungi activities.

近年来相继提出了许多抗白念珠菌药物作用的新靶点并成功开发出一些活性强大，疗效确切的抗真菌药，如以真菌细胞壁为靶点开发出棘白菌素类药物卡泊芬净、米卡芬净等，该类药物主要抑制β-葡聚糖合成酶，体外对氟康唑耐药的念珠菌属及真菌生物被膜表现出强大的抗菌活性，又由于β-葡聚糖合成酶在哺乳类动物细胞内不存在，故具有高效低毒的临床效果，是一极具前途的新型抗真菌药；以真菌细胞膜为靶点开发出Histatin类药物，虽然作用机制目前还不完全明了，但其作用不同于临床常用的多烯类和氮唑类，并已经发现Histatin5对两性霉素B和氮唑类耐药的念珠菌有效，并且对非白念珠菌如光滑念珠菌、克柔氏念株菌、隐球菌等也有杀灭作用；通过对植物药物的研究发现黄连素和丁香罗勒Ocimum gratissimum L。

In the United States, chronic alcoholism and hepatitis C are the most common ones.

在美国，慢性酒精中毒，肝炎是最常见的。

If you have any questions, you can contact me anytime.

如果有任何问题，你可以随时联系我。