耐药的

Objective: To study the anticonvulsive action of scorpion alcoholic extraction on phenytoin-resistant convulsive rats made by direct cortical electrical stimulation in order to investigate the mechanism of antagonizing drug-resistance of SAE.

中文摘要：目的：研究全蝎乙醇提取物(scorpion alcohol extraction，SAE)对电刺激大脑皮层点燃耐苯妥英钠大鼠惊厥模型的对抗作用，并探讨其抗耐药作用机制。

Objective To investigate the role of bcl-2 gene in multidrug resistance in human bladder cancer.

目的 探讨bcl-2基因在人膀胱癌多药耐药中的作用。

On the basis of the above results, we are now choose three kinds of Chinese medicine—fritillary,fourstamen stephania root,szechwan lovage rhizome which more recognized resistance has reversed the active ingredient, among single ingredient and the compound, to make particles—formulation of compound fritillary particles, as a therapeutic drug.

在上述成果基础上，我们从单味药到复方，选取当前较为公认的具有逆转肿瘤细胞多药耐药活性成分的三味中药浙贝母、防己、川芎，制成颗粒饮片——复方浙贝颗粒配方，作为治疗药物。

breast cancer cell line MCF-7 were marked killed by trametes robiniphila murr in certain concentration. The IC50 of trametes robiniphila murr in three days to MCF-7 was about 0.05mg/ml. Its cell toxin were increased while the touched time was delayed or the concentration was advanced. Trametes robiniphila murr also can advance cell toxin of adriamycin and reverse resistance of MCF-7/Adr.

用MTT 法测定不同浓度的槐耳浸膏作用不同时间下对乳腺癌细胞系MCF-7 的杀伤作用，同时测定应用槐耳浸膏时对阿霉素的增敏作用和耐药逆转作用；结论：金克在一定范围内对乳腺癌细胞系具有明显的杀伤作用，其作用3 天时，IC50 在0.05mg/ml 左右，随着药物浓度升高和作用时间的延长其杀伤作用相应的增强，对阿霉素化疗具有增敏作用和逆转耐药作用。

Objective To study the resistance of methicillin-resistant staphylococci against antibiotics.

目的 研究耐甲氧西林葡萄球菌的耐药状况。

Objective To investigate clinical infection and resistance of methicillin-resistant staphylococcus.

目的 探讨耐甲氧西林葡萄球菌的临床感染及耐药现状。

Consider to make clear in recent years, second acid is calcic - Bowman does not move bacillus clinical bacterium of single born of the same parents of the detached rate that go up and verdigris holiday comparatives, have the tendency that year after year rises, the fundamental condition pathogenic bacteria that already became the infection inside the courtyard [1] , have to a variety of antibacterial content be able to bear or endure higher property of a medicine [1, 2] , for this, we are monitored and statistic analysed my courtyard to came 1998 2004 7 years a second acid is calcic - the clinical infection condition that Bowman does not change bacillus, to 14 kinds of antibacterial content be able to bear or endure property of a medicine and be able to bear or endure medical tendency, sum up a report to be as follows now. 1 material and method all data all come from 1.1 basic materials to came on January 1, 1998 my courtyard outpatient service was mixed on December 31, 2004 the specimen sending check of inpatient, via clinical microbiology the lab is fostered and classics appraisal is second acerbity calcium - Bowman does not move bacillus to affect case of illness, with clinical and commonly used antibacterial at the same time content makes the kill that medical quick detects. 1.2 bacteria appraisal is mixed medical quick experiment uses live thing VITEK32 of Mei Li dust is full automatic the bacterial appraisal of bacterial analysis system and its form a complete set gets stuck and medical quick card undertakes detecting, 1998~2000 year use GNI appraisal gets stuck, 2001~2004 uses GNI+ card.

近年探究表明，乙酸钙-鲍曼不动杆菌临床上的分离率和铜绿假单胞菌相当，并有逐年上升的趋向，已成为院内感染的重要条件致病菌[1]，对多种抗菌药物有较高耐药性[1，2]，为此，我们监测并统计分析了我院1998年至2004年七年间乙酸钙-鲍曼不动杆菌的临床感染情况，对14种抗菌药物的耐药性及耐药趋向，现总结报道如下。1材料和方法1.1基本资料所有资料均来自于1998年1月1日至2004年12月31日我院门诊和住院病人的送检标本，经临床微生物学实验室培养并经鉴定为乙酸钙-鲍曼不动杆菌感染病例，同时以临床常用抗菌药物作药敏检测的结果。1.2细菌鉴定和药敏试验采用生物梅里埃VITEK32全自动细菌分析系统及其配套的细菌鉴定卡和药敏卡进行检测，1998~2000年使用GNI鉴定卡，2001~2004使用GNI+卡。

Coli. Methods Among 95 unrepeated strains isolated from clinic, 38 positive strains tested by ESBLs confirmatory test were collected from HAI and CAI subjected to detection for drug resistant gene TEM, SHV, CTX-M-1 and for disinfectant resistant gene qacE△l-sull by polymerase chain reaction.

收集从临床标本分离的大肠埃希菌95株，经ESBLs确证试验将其中38株阳性菌株分为医院与社区获得性感染2组，用聚合酶链反应检测耐药基因TEM、SHV、CTX-M-1以及耐消毒剂基因qacE△1-su l1。

JPYFHY Recipe can inhibite the tumor of lung cancer transplanted animals, and the JPYFHY Recipe drug-serum can block the prolife ration of A549/DDP in vitro by inducing cancer cell apoptoses and boking cell cycle; It can enhance the chemotherapy synergism effects when they are used in combination and reverse multidrug resistance which because of DDP. The mechanism of these reversing drug resistance maybe is related to downregulating the expression of MRP and GST and upregulating the expression of TopoⅡ.

健脾益肺化瘀方对动物移植性肺癌具有抑瘤作用，能阻滞肺癌细胞进入增殖期，从而达到抑制肺癌细胞生长的目的；并能增强DDP的敏感性和具有对DDP的耐药逆转作用，其作用机理与健脾益肺化瘀方抑制A549／DDP耐药基因MRP和GST的表达和增强TopoⅡ活性密切相关。

When the platform of screening β-lactamse inhibitor is constructed,it can not only be used to find new compounds for treating bacteria which resist β-lactam antibiotics, but also be used to screen inhibitors of hydrolase or modifying enzyme which is related to drug resistent bateria.

通过建立β-内酰胺酶抑制剂筛选的平台，不仅为寻找治疗β-内酰胺类抗生素耐药菌开辟一条新途径，并且这一新方法也适用于筛选与细菌耐药有关的其它一些由细菌产生的水解或修饰酶的抑制剂。

In the United States, chronic alcoholism and hepatitis C are the most common ones.

在美国，慢性酒精中毒，肝炎是最常见的。

If you have any questions, you can contact me anytime.

如果有任何问题，你可以随时联系我。