耐受的

To investigate whether the expression of cdc2 and cyclin B1 in spermatogenic cells during spermatogenesis is actually a temperature dependent event, in situ hybridization, Western blotting and immunohistochemistry analysis were used to study the expression of cdc2 and cyclin B1 in normal and cryptorchid testis. Results showed that heat would differentially hurt male germ cells in different developmental stages during spermatogenesis, especially the pachytene primary spermatocytes. Most of spermatogonia in contralateral cryptorchid testis were not harmed fatally by heat as yet, indicating that spermatogonia could resist to beat to a certain extent. In this case spermatogonia could develop to pachytene/diplotene primary spermatocytes, but they could not acquire the ability to complete the transition from mitosis to meiosis, and then appeared to go through apoptosis. Therefore, we could not find the descendants of meiosis: secondary spermatocytes and round spermatids, elongated spermatids and spermatozoon. The abdominal temperature had no significant influence on the transcription of cdc2 and cyclin B1 in the spermatogonia and pachytene/diplotene primary spermatocytes. In normal rabbit testis, cyclin B1 increased in the pachytene/diplotene primary spermatocytes before meiosis and reached its peak in the spermatids.

为了解精子正常发生过程中cdc2和cyclin B1表达的低温依赖性，我们利用原位杂交和免疫组化等方法，研究了正常和隐睾精子发生过程中cdc2和cyclin B1的转录和翻译调控活动，结果表明：（1）热对各阶段的雄性生殖细胞都有损害，粗线期的初级精母细胞尤为敏感，实验性隐睾内的精原细胞尚未完全受到"致命"影响，说明精原细胞对热有一定的耐受性，但即使成为粗线期／双线期初级精母细胞，却未能获得由有丝分裂过渡到减数分裂的能力，呈现不同程度的凋亡，所以在整个切片中找不到源自减数分裂的产物----次级精母细胞、圆形精子细胞，更谈不上长形精子细胞和精子的形成；（2）腹腔高温未明显地影响隐睾精原细胞和粗线期/双线期初级精母细胞中cyclinB1和cdc2的转录，说明高温并不是通过影响cyclin B1和cdc2的转录活动而导致生精过程阻断的；（3）正常兔睾丸组织中，〓在精原细胞和粗线期／双线期精母细胞中均有表达：cyclin B1蛋白在减数分裂前期的粗线期／双线期初级精母细胞中的表达量增加，于变态末期的精子细胞中达高峰。

The comparisons of biochemistry between OP and OR rats The differences between OP and OR rats included not only body weight, but lipids metabolism and insulin sensitivity as well, characterized with insulin resistance, increasing in serum free fatty acids and ketone body, and hepatic TC and TG in OP rats. However, no significant differences were observed in serum TG, TC, LDL, HDL and fasting glucose between OP and OR rats.⑶Comparisons of metabolites in serum, urine and liver tissue between OP and OR rats①There were significant differences in amino acids concentration between OP and OR rats,especially in liver tissue, such as high concentrations in ketogenic and glucogenic amino acids in OP rats, suggesting differences in amino acids metabolism;② The different metabolites between OP and OR rats included increasing of various saturated fatty acids and decreasing of polyunsaturated fatty acids in OP rats;③The urinary metabolites analysis indicated that different structure or metabolism of gut microflora might exist between the two phenotypes, which probably influenced the regulation of body weight gain;④The end-products of catecholamines in urine and intermediates of krebs cycle in serum in OP rats were all up-regulated, suggesting that the activity of sympatheic nervous system and energy metabolism was higher in OP rats than OR rats.

胰岛素耐受实验和胰岛素敏感指数表明OP动物的胰岛素敏感性较OR动物下降，而OP大鼠血清中游离脂肪酸、酮体、肝脏总胆固醇和甘油三酯水平显著升高；但是，OP与OR大鼠血清中总胆固醇、甘油三酯、低密度脂蛋白、高密度脂蛋白和空腹血糖等的水平并无显著性差异；⑶肥胖易感与肥胖抵抗大鼠血清、尿液和肝脏组织提取物中代谢物的比较研究表明：①OP与OR大鼠的血清、尿液和肝组织提取物中多种氨基酸的含量存在显著差异，并以肝组织中的差异氨基酸数量为最多，包括各种生酮和生糖氨基酸水平在OP组的升高，说明氨基酸代谢的差异是两种体重表型大鼠之间存在的重要差异特征之一；②OP与OR动物肝脏和血清差异代谢物中包含多种饱和长链脂肪酸的升高如十四烷酸、十六烷酸、硬脂酸等和多不饱和脂肪酸的下降如亚油酸和花生四烯酸，说明两种体重表型动物的肝脏脂肪酸代谢存在明显差异；③长期高脂饮食喂养后，动物的尿液代谢物分析表明OP与OR动物体内的肠道菌群结构存在差异，这些菌群上的差别可能在动物体重增长的调节上产生影响；④与OR动物相比，OP动物尿液代谢物中儿茶酚胺类递质的代谢终产物如高香草酸、扁桃酸和4-羟基苯乙酸明显升高。

S which are sold, but Viva Plex offers an incredible 95% skin tolerability level, and this means that it is practically safe for all women, and can be used safely as a pregnancy cream by teenagers, young mothers, and those who are usually sensitive to creams.

女性谁一直在跟自由的可怕的妊娠纹自己却发现他们不敏感，一个怀孕的奶油很多s的带宽出售，但万岁丛提供了一个令人难以置信的95％的皮肤耐受性的水平，这意味着它实际上是安全的所有妇女，可作为十几岁的青少年怀孕霜安全，年轻的母亲，以及谁通常敏感的药膏。

objective trimetazidine has shown anti-ischemic properties to improve exercise tolerance without haemodynamic effects and direct cyto protective effect on the myocardium.however,it is not clear whether trimetazidine has beneficially effect on severe ischemic cardiomyopathy.methods 19patients（68±9）years with postnecrotic left ventricular dysfunction（ejection fraction31.7%±5.4%）were studied to examine the benefit of adding60mg a day of trimetazidine for3months to the classical therapy.the assessment included clinical evaluation,electrocardiography and echocardiography.results after adding60mg a day of trimetazidine for3months,attack of angina was relieved and dyspnea was improved（p.05）.but heart rate,systolic blood pressure,rate pressure product,ejection fraction,left ventricular volume and global wall motion index were not changed.conclusion trimetazidine seems to improve clinical status while can not change oxygen supply-to-demand ratio without adverse effects in patients on severe ischemic carˉdiomyopathy.

目的 曲美他嗪是一种新型的抗心肌缺血的药物，能够改善患者的运动耐量和心肌的直接保护作用同时并没有血流动力学效应。但目前对于严重缺血性心肌病患者的临床治疗价值还需要进一步观察。方法 19例（68±9）岁确诊为缺血性心肌病（左心室射血分数0%）的患者在常规治疗的基础上加用每日60mg曲美他嗪治疗3个月，随诊观察患者临床情况以及超声心动图指标的变化。结果 19例患者均可耐受在常规治疗基础上加用每日60mg曲美他嗪的治疗，随诊发现患者心绞痛发作明显减少，运动耐量明显改善。同时患者心率、收缩压、心率血压乘积、左心室射血分数、左心室容量以及整体室壁运动指数无明显改变。结论缺血性心肌病的患者在常规治疗基础上加用曲美他嗪是安全的，同时其能明显改善患者的临床状态，而这种作用并不改变心肌氧的供求比值。

Matsuyama et al used calcium phosphate cement, which polymerizes at lower temperatures.37,38 Results were good in terms of pain relief (8.6 preoperatively and 2 postoperatively on the visual analog scale), neurologic recovery and kyphosis restoration (vertebral height was restored to 68%, compared to 41% preoperatively).37,38 This combination of maximal/minimal surgical treatment has value especially in neurologically compromised patients with indication for surgery, who cannot tolerate long procedures and large blood loss due to medical comorbidities.

Matsuyama等人使用磷酸钙骨水泥，其硬化反应温度较低[37，38]，结果表明疼痛缓解良好（视觉模拟评分从术前的8.6分减至术后的2分），神经功能恢复和后凸畸形矫正良好（椎体高度从术前的41％恢复至术后的68 ％）[37，38]，这个&最大/最小&的手术组合治疗方法，尤其适合伴有神经症状而不能耐受长时间的手术和大量失血的患者。

Our results showed 1 The changes in trends of leaf traits response to the rainfall gradient differed either with species or with a specific trait; 2）The same trends were found at the functional group level, However, leaf traits for grasses tends to be less sensitive, then for forbs, and the legumes is the most sensitive functional group along the rainfall gradient, indicated that the Grass function group is quite strong to the soil moisture content tolerance, and which certainly explained to the local vegetation distribution and the substitution between species.

主要结论如下：1 叶片性状在降雨量梯度上的变化趋势在物种水平上表现出多样化的特点，性状的变化趋势是否有显著的格局取决于物种或特定性状。2 叶片性状对水分梯度的响应在功能群水平上表现出各自的特点，Grass功能群对水分梯度的响应敏感性较低，Forb居中，Legume表现出较强的敏感性，表明Grass功能群对水分的耐受性比较强，这在一定程度上解释了当地克氏针茅草原上目前以禾草类为主的现状，对物种之间的替代有一定的指示性。

Several other poster presentations reinforced the message that once-weekly epoetin was effective, although none of these others had a comparator dose. Two posters presented results from meta-analyses of epoetin alfa clinical trials. One was carried out by Pere Gascon, MD, PhD, and colleagues, from the University of Barcelona, in Spain, and involved 4296 patients with mixed tumor types, while the other, reported by Mario Dicato, MD, from the Luxembourg Medical Center, involved 2019 patients with breast cancer. Both concluded that 40,000-IU epoetin alfa is effective and well tolerated; it ameliorates the impact of chemotherapy on hemoglobin and improves quality of life, thus representing "good anemia management," the researchers concluded.

许多其它的墙报研究同样证实每周投予一次红血球生成素是有效的，虽然其它研究中未使用比较组；另两项比较红血球生成素阿法临床试验结果的综合分析，一项是由Pere Gascon医师与其来自西班牙巴塞隆纳大学的同事，收纳了4，296位各种肿瘤种类病患的研究；另一篇是来自Luxembourg医学中心Mario Dicato医师，收纳2，019位乳癌病患的研究，这两项研究的结论都是40，000单位的红血球生成素阿法同样有效、且耐受性佳；该疗法降低化学疗法对血红素的不良影响，且改善了生活质量，因此可以说为是「良好贫血处理」的标竿。

L.monocytohenes widely exists in the nature, and is not easy to be freeze, and can bear high infiltrator pressure, so it can exist in soil, surface water, sewerage, waster water, plant, plant feed, fester vegetable, so the animal eat them into their body easily, and from mouth enter our body, it is said that 0.6-16% stool check from healthy person can also find listeriosis growing, and even can found 70% healthy person can carry listeriosis short time in their body.

单增李斯特氏菌广泛存在于自然界中，不易被冻融，能耐受较高的渗透压，在土壤、地表水、污水、废水、植物、青储饲料、烂菜中均有该菌存在，所以动物很容易食入该菌，并通过口腔-粪便的途径进行传播。据报道，健康人粪便中单增李氏菌的携带率为0.6-16%，有70%的人可短期带菌，4-8%的水产品、5-10%的奶及其产品、30%以上的肉制品及15%以上的家禽均被该菌污染。

Neither the killing of Mr Zarqawi nor any breakthrough on the political front will stop the insurgency and the fratricidal murders in their tracks.

在对危险的南部地区访问时，他斥责什叶派民兵领导人对中央集权的挑衅行为。

In fact,I've got him on the satellite mobile right now.

实际上 我们已接通卫星可视电话了