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The immune system is exquisitely sensitive and can distinguish between very subtle changes in chemical composition. Patients may be tolerant of a given drug but intolerant of another drug with closely related chemical structures. There is evidence that patients tolerant of penicillin may be intolerant of cephalosporins.

免疫系统非常敏感,可以识别化学物质的细微变化,病人可以耐受一个给定的药物,而可能不能耐受化学物质非常相近的另一个物质,也有证据表面有的病人能耐受青霉素而不能耐受头孢。

Thus, patients who are intolerant of penicillin may also be intolerant of cephalosporins, and further, cephalosporins may induce anaphylaxis in patients with a history of penicillin anaphylaxis.

内酰胺类产品是一类具有β内酰胺环化学结构的产品,具有潜在过敏性可导致人过敏,由于对β内酰胺类的不耐受性,超敏性在此类产品性也可能存在而引起过敏,有例子表明在青霉素和头孢类之间存在交叉污染,因此,不能耐受青霉素的病人也可有耐受头孢产品,而且,头孢也可诱发有青霉素过敏史的人过敏。

That means Pho85 kinaseand calcineurin were involved in salt tolerance with an identical target protein or in 中科院上海生化与细胞所博士学位论文摘要 the same pathway. Inhibition of calcineurin decrease the YPH499, pho80? mutant,and pap1 (pcl7)? mutant Mn2+ tolerance but not that of pho85? mutant and thepho85? mutant was more sensitive to Mn2+ than YPH499, pho80? mutant, and pap1(pcl7)? mutant even with the addition of cyclosporin A. Therefore, the conclusioncould be drawn that PHO85 gene played a dominant role in Mn2+ homeostasisregulation in compare with calcineurin. As for Ca2+ tolerance, cyclosporin A canincrease the tolerance to Ca2+ of all the mutant mention above, that means Pho85kinase and calcineurin function antagonistically in regulation of Ca2+ homeostasis.In Bioinformatics, BRI3 gene is a novel gene without any function clue but givehigh conservation in mammalian.

我们通过钙调磷酸酶的特异抑制剂环孢菌素A研究了YPH499、+2+pho85缺失株、pho80缺失株、pap1缺失株在钙调磷酸酶失活后对Na、Mn、2+Ca金属离子敏感性的变化,结果显示Pho85蛋白激酶和钙调磷酸酶通过直接+或间接激活同一个靶蛋白或途径来增强细胞对Na的耐受;和钙调磷酸酶相比,2+PHO85的缺失对酵母细胞Mn耐受性的破坏是相对控制性的,钙调磷酸酶的失2+活不能进一步降低pho85缺失株对Mn的耐受能力;Pho85和钙调磷酸酶在对2+Ca的耐受调节中是相互拮抗的,钙调磷酸酶的失活能增加pho85缺失株和2+pho80缺失株的Ca耐受。i中科院上海生化与细胞所博士学位论文摘要对本实验室克隆的人新基因BRI3进行系统的生物信息学分析,发现它是一个在哺乳动物中保守的,但功能未知的基因。

The stress resistance of common roof garden plants, e.g. Dahlia hybrida, Callistephus chinensis, Calendula officinalis and Chrysanthemum multicaule were determined by mensurating such index as chlorophyll content, electrolyte leakage, water content, Pro content, MDA content and dissoluble sugar content. The result indicates that Dahlia hybrida is the best, Callistephus chinensis next, Calendula officinalis and Chrysanthemum multicaule are weaker as to drought resistance;while in the experiment on coldness resistance, the ability to bear coldness ranks from the best to the worst is Poa annua, Festuca arundinacea and Trifolium.

对小丽花、矮翠菊、金盏菊与黄晶菊等常见城市绿化植物进行的抗逆性试验研究,测定了叶绿素含量、膜相对透性、相对含水量、脯氨酸含量、丙二醛含量、可溶性糖含量等指标,结果表明:在抗旱性试验中小丽花的耐受性最强,矮翠菊次之,金盏菊与黄晶菊的耐受性较弱:抗寒性试验中所选植物材料的耐受性次序分别是早熟禾强于高羊茅强于三叶草。

This paper includes the following aspects: the concept of chimerism, type, methods and the establishment of the mechanism of immune tolerance induction, the chimeric detection and its clinical application of a research progress.

本文就嵌合体的概念、种类、建立嵌合体的方法及其诱导免疫耐受的机理,嵌合体的检测及临床应用的研究进展作一综述。

"Although a longer follow-up is required for assessment of the durability of response, the patient's course indicates that autologous hematopoietic stem cell transplantation may be a way to reinduce tolerance in patients with SLE," the authors write.

作者写道:「尽管仍需要更长时间的随访,来评价这种治疗效果的持久程度,但是患者的治疗过程提示,自身同源性血液干细胞的移植,可能是患有SLE患者再次唤起免疫耐受的一种方法。

At last, the effects of JA on the bile salt resistance of Bifidobacteria were studied.The test proved that:Deoxycholic acid Na-Salt had intensely toxical action on Blm and Bbm;Adding glucose and fructose in media could decrease the lexical action on Bbm.but inulinand JAP had not apparent effect.

初步研究了菊芋对双歧杆菌的胆盐耐受性的影响,实验表明,脱氧胆酸钠盐对Blm和Bbm有一定毒性作用;在培养基中补充一定量的葡萄糖和果糖可以改善Bbm的胆盐耐受性,而菊糖和菊芋粉对提高Blm和Bbm的胆盐耐受性没有明显作用。

The article adopts "humidity ratio" integrated emendation method and other two traditional emendation methods in emendation calculating on several group test results. The tests are : simulating test in artificial climate room on 110kV substation equipment of Yangbajing, Lasa and Yanghu by Xi"an High Voltage Lab; power frequency voltage discharge test of ZS-110 by Yunnan provincial electrical research academy. It compares and analyses the equipment test voltage emendated to standard atmosphere conditions with the equipment nominal withstanding voltage. And then it concluded that: the emendation value educed by "humidity ratio" integrated emendation method is basically equal or close to the equipment nominal withstanding voltage; but the values by two traditional emendation methods are mostly higher.It also proves that,"humidity ratio integrated emendation method is more perfect than any other methods, and it can reflect the influence degree of atmospheric parameters on electrical equipment outer insulation discharge voltage actually. The method should be spread in designing high elevation power projects.

文中选择&比湿&综合校正法和两种传统校正法,分别对西高所为羊八井、拉萨、羊湖110kV变电所设备所做的人工气候室模拟试验数据及云南中试所做的ZS-110工频放电电压试验数据进行校正计算,将试验电压的校正值与试验设备的标称耐受电压水平进行比较分析;认为:&比湿&综合校正法的校正值与设备耐受电压水平基本相等或接近,而两传统校正法的校正值大多高于设备耐受电压水平;进一步证明,&比湿&综合校正法是目前诸多校正法中较为完善的,能真实地反映大气参数对电气设备外绝缘放电电压的影响程度的校正法,在高海拔电力工程设计中应推广应用。

MNSFP was a previously identified novel implantation-related factor that needed to be further investigated in our lab, and is a lymphokine produced by suppressor T cell.

MNSFD是本实验室正在研究的另一个新发现的着床相关因子,它是一种由抑制性T细胞合成的具有非特异性免疫抑制作用的淋巴因子,因其能抑制IL-4的分泌和Th2细胞的产生,所以推测其可能与母胎间免疫耐受的形成有关,但有待于研究证实。

Initial antiretroviral therapy is more likely to fail in patients who are infected with drug-resistant virus.

对於那些受到对药物耐受的病毒的感染的患者,最初的抗逆转录治疗更容易以失败而结束。

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