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Clonal anergy and suppressor cells are main mechanisms of the tolerance.

克隆不应答和抑制细胞是耐受的主要机制。

Hypoxia induces the resistance of tumor cells[4];and the heterogeny of solid tumors result in the appearance of subpopulations of differentproliferative potency in the same tumor tissue, so that the target cells sensitive to cell cyclespecific drug are reduced.

目前有研究认为:实体瘤部分细胞缺氧和肿瘤组织的异质性可能是导致肿瘤对放疗和化疗产生耐受的主要原因之一,缺氧可以诱导肿瘤细胞对放疗和化疗的耐受性[4],实体肿瘤的异质性可使同一瘤组织内具有不同增殖潜能的癌细胞亚群存在,导致细胞周期特异性化疗药物作用的靶细胞减少。

AIM: To explore the mechanism of immune tolerance to experimental autoimmune myasthenia gravis in nasally tolerized rats and Wistar rats.

目的:探讨鼻腔耐受和Wistar大鼠对实验性自身免疫性重症肌无力耐受的机制。

The concept of ischemic tolerance is established on the base that sublethal heat shock or low-dose ischemic injuries produce tolerance in cells and tissues to subsequent exposure to heat or ischemic injury.

缺血耐受的概念是在亚致死性热休克和低强度缺血损伤可以诱导受其打击的细胞或组织中产生缺血耐受的试验基础上形成的。

Addition of exogenous IL-2 to the tolerant BALB/c→B6 MLR cultures system, only partially restored the proliferative responses, indicating that anergic T cells clones may induce tolerance to the allograft.

在耐受BALB/c→B6小鼠的单向混合淋巴细胞反应体系中加入外源IL-2可以部分反转耐受BALB/c小鼠脾细胞的增殖反应,表明本实验诱导耐受的机制可能与克隆不应答有关。

The maintainance of immunotolerance is considered to depend on central tolerance and peripherial tolerance, and the regulatory T cell has great role in maintaining immune tolerance and stablizing immune response.

目前认为维持机体免疫耐受的主要机制是中枢耐受和外周耐受,在外周耐受中调节性T细胞具有非常重要的作用,已成为当前免疫学研究的热点。

Myspalax cansus (Rodentia, Myospalacinae, Myspalax)which lives on the loess plateau of our country. This unique underground rats life-long living under the cave, it developed many hypoxic tolerance protect mechanism to adapt its special circumstances at in organsall levels. In this study,we used Gansu zokor and SD rats (Sprague-Dawley)for the object, do serious hypoxia tolerance experiment, to explore the hypoxia tolerance extreme of Gansu zokor, analysis the difference hypoxia tolerance between Gansu zokor and SD rats at same oxygen concentration; The changes on their cardiac muscle organization structures in hypoxia tolerance process ; The expression of HSP70 between normoxic and hypoxic control in cardiac muscle organization of two animals , to find the relativity in all the results.

甘肃鼢鼠隶属啮齿目,鼢鼠亚科,鼢鼠属,是我国黄土高原特有地下鼠,由于终生营地下洞穴生活,使得甘肃鼢鼠发展出良好的低氧耐受保护机制,本研究以甘肃鼢鼠和SD大白鼠(Sprague-Dawley)为对象,进行低氧耐受实验,探寻甘肃鼢鼠的低氧耐受极限,比较二者低氧耐受的差异;以及低氧耐受不同时程,二者心肌组织显微和超微结构的变化差异;比较分析左心室组织中HSP70的表达变化和心肌耐受过程中组织结构变化的相关性。

It has been shown, however, that in terms of immune function, a transitional stage of dendritic cell maturation exists between immature myeloid dendritic cells and mature dendritic cells, which were named semimature dendritic cells.

新的研究发现一种半成熟树突状细胞亚群,其高表达主要组织相容性复合体Ⅱ、中等表达CD40、CD80和CD86等分子,在自身免疫性疾病中表现出诱导免疫耐受的潜能,其与未成熟树突状细胞一道被认为是致耐受细胞。

To acquire the tolerance of allografts has two processes: induction process and maintenance of tolerance.

移植耐受的形成分为两个过程:移植耐受的诱导和移植耐受状态的维持。

Cell-transferred tests in vivo and in vitro showed no suppressive cells existing in the spleens of the tolerant BALB/c mice.

对联体后耐受的BALB/c小鼠进行体内和体外细胞转移实验,均未显示耐受小鼠脾细胞中存在抑制细胞活性。

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