耐受性

The comparisons of biochemistry between OP and OR rats The differences between OP and OR rats included not only body weight, but lipids metabolism and insulin sensitivity as well, characterized with insulin resistance, increasing in serum free fatty acids and ketone body, and hepatic TC and TG in OP rats. However, no significant differences were observed in serum TG, TC, LDL, HDL and fasting glucose between OP and OR rats.⑶Comparisons of metabolites in serum, urine and liver tissue between OP and OR rats①There were significant differences in amino acids concentration between OP and OR rats,especially in liver tissue, such as high concentrations in ketogenic and glucogenic amino acids in OP rats, suggesting differences in amino acids metabolism;② The different metabolites between OP and OR rats included increasing of various saturated fatty acids and decreasing of polyunsaturated fatty acids in OP rats;③The urinary metabolites analysis indicated that different structure or metabolism of gut microflora might exist between the two phenotypes, which probably influenced the regulation of body weight gain;④The end-products of catecholamines in urine and intermediates of krebs cycle in serum in OP rats were all up-regulated, suggesting that the activity of sympatheic nervous system and energy metabolism was higher in OP rats than OR rats.

胰岛素耐受实验和胰岛素敏感指数表明OP动物的胰岛素敏感性较OR动物下降，而OP大鼠血清中游离脂肪酸、酮体、肝脏总胆固醇和甘油三酯水平显著升高；但是，OP与OR大鼠血清中总胆固醇、甘油三酯、低密度脂蛋白、高密度脂蛋白和空腹血糖等的水平并无显著性差异；⑶肥胖易感与肥胖抵抗大鼠血清、尿液和肝脏组织提取物中代谢物的比较研究表明：①OP与OR大鼠的血清、尿液和肝组织提取物中多种氨基酸的含量存在显著差异，并以肝组织中的差异氨基酸数量为最多，包括各种生酮和生糖氨基酸水平在OP组的升高，说明氨基酸代谢的差异是两种体重表型大鼠之间存在的重要差异特征之一；②OP与OR动物肝脏和血清差异代谢物中包含多种饱和长链脂肪酸的升高如十四烷酸、十六烷酸、硬脂酸等和多不饱和脂肪酸的下降如亚油酸和花生四烯酸，说明两种体重表型动物的肝脏脂肪酸代谢存在明显差异；③长期高脂饮食喂养后，动物的尿液代谢物分析表明OP与OR动物体内的肠道菌群结构存在差异，这些菌群上的差别可能在动物体重增长的调节上产生影响；④与OR动物相比，OP动物尿液代谢物中儿茶酚胺类递质的代谢终产物如高香草酸、扁桃酸和4-羟基苯乙酸明显升高。

Methods:With gastric esophagus manometric catheter designed by ourselves, the gastric proximal end compliance and gastric proximal end sense threshold of 9 healthy volunteers and 31 RE patients were measured when gastric proximal end pressure increasing.

采用自行设计的胃食管一体式导管，在不断增加胃近端压力时，同步测量 9例健康志愿者和 31例 RE患者的胃近端顺应性和感觉功能。结果和结论：RE组胃近端感觉阈值显著低于正常组。 RE组及正常组的最小感觉阈值、较强感觉阈值、最大耐受阈值分别为：190± 12 3、316± 130(P 。0 5 )；2 5 0± 10 7、45 1± 95 (P 。0 1)；314± 92、480± 75 (P 。0 1)。

Objective To study the role of food intolerance-specific IgG and TNF-α in the pathogenesis of prurigo nodularis.

目的 探讨食物不耐受sIgG和TNF-α在结节性痒疹发病机制中的作用。

"Prompt recognition of sympathetic abnormalities might result in earlier therapeutic interention, reduced orthostatic intolerance, and increased quality of life," Dr. Raffaello Furlan from the Uniersity of Milan and colleagues write in the January issue of Hypertension.

米兰大学Raffaello Furlan博士和其同事在《高血压》杂志1月份期刊中写到，"及早发现交感神经冲动异常可指导无直立性低血压的PD患者早期治疗，减少直立耐受不能发生，提高生活质量"。

Objective To investigate the relationship among 3 GP Ⅱb and the funciton of GP Ⅱb T13959 G in the platelet transfusion refractoriness.

目的：研究血小板膜糖蛋白Ⅱb三种基因多态性之间的关系及CP Ⅱb， T13959 G在血小板输注耐受中的作用。

Brain ischemic preconditioning is that transient ischemia in sublethal dose will result in tolerance to the following ischemia in lethal dose for long time.

脑缺血预处理即给予短暂亚致死量缺血可对随后的长时间致死性缺血损伤产生耐受。

Note that the latter amount reflects the method's limits with respect to confidence and reproducibility and does not represent a tolerance level.

注意后都的数据反应了方法的可信度及再现性，但不代表而耐受水平。

Angiectasis, permeability were increased , inflammatory cell were transuded; The cardiac muscle injury conditions after hypoxia 4 h were similar with hypoxia 2h group, appeared lipid droplet, implied the oxidative metabolism of lipid got obstacle started from then; The cardiac muscle injuried conditions were got little improvement in hypoxia 6 and 8 hours team, mitochondria were increased and aggregatived, normal cell junction, sarcomere contract weaked; in hypoxia 10h group , mitochondria were increased and aggregatived obviously, a few glycogenosome were assembled, transverse tubule were expanded, all the changes may be the adaption of Gansu zokors in the hypoxia tolerance process to 4% hypoxia extent gradually.

在4%严重低氧耐受过程中，甘肃鼢鼠心肌超微结构在2h组出现血管扩张，通透性增加，有炎细胞渗出，异染色质边集；4h组心肌损伤状况与2h组接近，出现脂滴，提示脂类的氧化代谢在此时开始发生障碍，6和8h组心肌损伤状况逐渐好转，线粒体聚集增多，细胞连接正常，肌小节收缩较前有所减弱；10组线粒体增多聚集，线粒体脊增粗更为明显，少量糖原颗粒聚集，脂滴较前有所减少，横小管扩张增大变粗，出现了与能量代谢有关的结构适应性变化。

Result］ On stress ulcer bleeding,astriction,diarrhea,abdomen palsy,intolerant intestinal nutrition and gastrointestinal functional score,the treatment group was better than the control one.

结果］在应激性溃疡出血、便秘、腹泻、腹麻痹、不能耐受肠内营养和胃肠功能评分等方面均优于对照组。

Result］ On stress ulcer bleeding,astriction,diarrhea,abdomen palsy,intolerant intestinal nutrition and gastro?intestinal functional score,the treatment group was better than the control one.

结果］在应激性溃疡出血、便秘、腹泻、腹麻痹、不能耐受肠内营养和胃肠功能评分等方面均优于对照组。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。