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耐受性

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Construction yeast and plant expression vector with original gene and mutated gene, transferred into tobacco plant by electroporation and Agrobacterium mediated transformation respectively, validating genic function. Under the glyphosate pressure, the transgenic yeast strains with good tolerance are screened. The mark named ATME-4-M and ATME-9 prives the attained genes have biological function.

成功地将epsps基因构建到酵母胞内表达载体pPIC3.5K和植物表达载体PBI121上,利用电击法转化酵母及农杆菌介导法转化烟草,转基因酵母在草甘膦压力下筛选出耐受性较好的菌株,标记为ATME-4-M和ATME-9证明了所获基因具有生物学功能。

The results indicate that intravenous CP may produce rapid hemodyn amic and clinical inprovement and be well tolerated in cardiac patient s with serious or emerqent conditions from heart tailure.

结果表明静脉输注CP能较快地改善重症和急症心衰病人的血液动力学和临床状态,耐受性良好。

The approval was based on data from four double-blind, randomized trials that compared the antianginal and anti-ischemic efficacy of ivabradine with placebo, atenolol, and amlodipine in 3,222 patients. Results obtained using a standardized exercise tolerance test showed that twice-daily administration of ivabradine, 5 and 7.5 mg, significantly decreased the incidence of anginal episodes.

这项核准案是根据4项双盲随机分派试验结果,这些试验针对3,222位病患,比较Ivabradine相较于安慰剂、atenolol、及amlodipine治疗心绞痛与减少心肌缺血的效果;以标准运动耐受性测试所得到的结果显示,每天投予2次5或是7.5毫客的Ivabradine可以显著地降低心绞痛发生的次数。

The approval was based on data from four double-blind, randomized trials that compared the antianginal and anti-ischemic efficacy of ivabradine with placebo, atenolol, and amlodipine in 3,222 patients. Results obtained using a standardized exercise tolerance test showed that twice-daily administration of ivabradine, 5 and 7.5 mg, significantly decreased the incidence of anginal episodes.

这项核准案是根据4项双盲随机分派试验结果,这些试验针对3,222位病患,比较Ivabradine相较於安慰剂、atenolol、及amlodipine治疗心绞痛与减少心肌缺血的效果;以标准运动耐受性测试所得到的结果显示,每天投予2次5或是7.5毫客的Ivabradine可以显著地降低心绞痛发生的次数。

The study showed that desloratadine had comparable efficacy with loratadine, and was well tolerated without cardiotoxic effects in treating patients with allergic rhinitis.

本研究显示,desloratadine治疗过敏性鼻炎和loratadine有相同的疗效,同时也有很好的耐受性,而且并未曾发生心脏毒性副作用。

The hypotensive effect of cevadine is directly positive correlation with the dosage.

藜芦碱在发挥显著降压作用的同时,未见明显的副作用,且反复给药无快速耐受性

Cevadine was isolated from Eranthis hyemalis and its effects on normal cats blood pressure, hypertension rats and their tolerance to cevadine were determined by using direct carotis and indirect arteria caudilis manometric methods.

目的 开发新型降压药奠定理论基础方法从藜芦中提取分离出藜芦碱,采用颈动脉直接测压法和尾动脉间接测压法,测定了其对正常猫血压、高血压鼠的影响及其快速耐受性

Because glial cell activation could also be involved in the development of opioid tolerance in rats, the authors studied the antinociceptive effects of ibudilast and morphine in different models of coadministration.

由于大鼠神经胶质细胞的激活也被证实与阿片样物质耐受性的产生有关,作者研究了异丁司特和吗啡在不同的共同给药模型中的镇痛作用。

Coadministration of ibudilast with morphine did not attenuate the development of morphine tolerance.

同时给予异丁司特和吗啡并不能减弱吗啡耐受性的产生。

Tolerability was assessed based on electrocardiographic results, occurrence of adverse events, changes in vital signs, and results of laboratory tests and physical examinations.

根据心电图结果,产生的副作用,生命体征的改变,实验室检测和体检的结果来评价其耐受性

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