羧基

Objective To express the functional domain at C-terminus of Clostridium difficile cytotoxin B and lay a foundation of developing effective vaccine against infection with Clostridium dificile and diagnostic antigen.

目的 表达并纯化艰难羧菌细胞毒素B羧基末端功能区片段，为制备高效防治艰难羧菌感染的疫苗和诊断抗原奠定基础。

The invention discloses an antibody against cattle piron and method for preparation, wherein the antibody is obtained by using polypeptide selected from the following polypeptide family as the antigen immunological animal, said polypeptide family is formed by the following polypeptides,(1) polypeptide of the amino acid residue sequence 1 in the sequence table,(2) polypeptide obtained by removing 1-24 amino acid residues continuously from No.

本发明所提供的制备牛朊病毒抗体的方法，是以选自下述多肽家族之一的多肽为抗原免疫动物得到的抗体；所述多肽家族由以下多肽组成：1具有序列表中序列1的氨基酸残基序列的多肽；2从序列1的自氨基端第1位氨基酸残基开始向羧基端连续去除1至24个氨基酸残基，和/或从序列1的自氨基端第264位氨基酸残基开始向氨基端连续去除1至23个氨基酸残基得到的多肽。

Furthermore, through molecular structural design, we have also synthesized stable dual functional diphenylether polymer intermediates of ABB' types possessing ortho-dicarboxylic at one aromatic ring and diamine groups at another beginning from Xylenol and 1-Chloro-3,4-dinitrobenzene as the raw materials.

中文摘要本研究应用自氧化法与氢化法两反应，成功而有劾地制备出芳香族含酸酐及二胺基之官能基单体，并进一步经由分子结构设计，从3，4-二甲苯酚及1-氯-3，4-二硝基苯为原料，转化合成出安定性高带有羧基与双胺基双官能基之堑新ABB'型二苯醚中间体，并成功地应用此中间体从事自聚合反应，而合成分歧状聚醚亚醯胺高分子。

The present invention concerns the compounds having the formula N-oxides, salts, stereoisomeric forms, racemic mixtures, prodrugs, esters and metabolites thereof, wherein R1 and R8 each are H, optionally substituted C1-6alkyl, C2-6alkenyl, C3-7cycloalkyl, aryl, Het1, Het2; R1 may also be a radical of formula (R11aR11b)NC(R10aR10b)CR9-; t is 0, 1 or 2; R2 is H or C1-6alkyl; L is -C-,-O-C-,-NR8-C-,-O-C1-6alkanediyl-C-,-NR8-C1-6alkanediyl-C-,-S2-,-O-S2-,-NR8-S2 ; R3 is C1-6alkyl, aryl, C3-7cycloalkyl, C3-7cycloalkylC1-4alkyl, or arylC1-4alkyl; R4 is H, C1-4alkylOC, carboxyl, aminoC, mono- or di(C1-4alkyl)aminoC, C3-7cycloalkyl, C2-6alkenyl, C2-6alkynyl or optionally substituted C1-6alkyl; R5 and R6 are H or C1-6alkyl.

本发明涉及右式化合物其N-氧化物、盐、立体异构形式、外消旋混合物、前药、酯及代谢物，其中R 1 及R 8 各是氢、C 1-6 烷基、C 2-6 烯基、C 3-7 环烷基、芳基、Het 1 、Het 2 ；R 1 也可以是式(R 11a R 11b )NC(R 10A R 10b )CR 9 -之基；t是0、1或2；R 2 是氢或C 1-6 烷基；L是-C-、-O-C-、-NR 8 -C-、-O-C 1-6 烷二基-C-、-NR 8 -C 1-6 烷二基-C-、-S 2 -，-O-S 2 -、-NR 8 -S 2 -；R 3 是C 1-6 烷基、芳基、C 3-7 环烷基、C 3-7 环烷基C 1-4 烷基或芳基C 1-4 烷基；R 4 是氢、C 1-4 烷基OC、羧基、氨基C、一-或二(C 1-4 烷基)氨基C、C 3-7 环烷基、C 2-6 烯基、C 2-6 炔基或任选被取代的C 1-6 烷基；R 5 及R 6 是氢或C 1-6 烷基。

A compound of formula wherein R1 is hydrogen, halo or methoxy; R2 is hydrogen, halo, methyl, ethyl or methoxy; R3 is carboxy, tetrazolyl, or -CONHSO2R where R is methyl, ethyl, phenyl, 2,5-dimethylisoxazolyl or trifluoromethyl; T is -CH2- or -SO2-; and ring A is 3-chlorophenyl, 4-chlorophenyl, 3-trifluoromethylphenyl, 3,4-dichlorophenyl, 3,4-difluorophenyl, 3-fluoro-4-chlorophenyl, 3-chloro-4-fluorophenyl or 2,3-dichloropyrid-5-yl; or a pharmaceutically acceptable salt or prodrug thereof, as well as pharmaceutical compositions containing them are described and claimed.

本发明涉及一种式化合物，其中R 1 是氢原子、卤素或甲氧基；R 2 是氢原子、卤素、甲基、乙基或甲氧基；R 3 是羧基、四唑基或－CONHSO 2 R 4 ，其中R 4 是甲基、乙基、苯基、2，5－二甲基异∴唑基或三氟甲基；T是－CH 2 －或－SO 2 －；环A是3－氯苯基、4－氯苯基、3－三氟甲基苯基、3，4－二氯苯基、3，4－二氟苯基、3－氟－4－氯苯基、3－氯－4－氟苯基或2，3－二氯吡啶－5－基；或其药用允许的盐或前药，还包括所阐述和要求权利的含有它们的药用组合物。

The results show that the perfect Honeycomb pattern films without defects within area of 0.8cm^2 can be obtained at the PS concentration ranges from 20 mg/mL to 50 mg/mL and PS/TEOS mass ratio less than 2. The films cast from the chloroform solution of dicarboxyl terminated PS were more perfect than those cast from the chloroform solution of monocarboxyl terminated PS. The perfect Honeycomb structure films could be obtained with both chloroform and benzene as solvents, but the pore diameter of films cast from benzene solution of PS was larger than that of films cast from chloroform solution of PS.

研究结果表明，聚合物浓度在20~50mg/mL，PS/TEOS质量比大于2：1的条件下可以制备结构完整的多孔膜，且制备的Honeycomb结构在0.8平方公分内无缺陷；采用双羧基封端的聚苯乙烯成膜效果好于单羧基封端的成膜效果；以氯仿和苯作为溶剂均可以制备完全Honeycomb结构的复合膜，但以苯为溶剂制备的多孔膜孔径较大。

BACKGROUND: The carboxyl terminuses of the Hsc70-interacting protein associate with many proteins in neurodegenerative diseases, which can promote the degradation of these proteins. Therefore, it is of a great significance to study the function of CHIP.

背景：热休克蛋白70羧基末端相互作用蛋白与许多神经退行性疾病的相关蛋白质存在相互作用，并促进这些蛋白质的降解，因此对热休克蛋白70羧基末端相互作用蛋白功能的研究具有非常重要的意义。

There are the non-saturated and carbon -carbon double keys and carboxyl group and special functional group derived from carboxyl group, so it is used in the polymerization and co-polymerization widely, can react with many kinds of the compounds, and produce a series of acrylic acid co-polymerization compound .

丙烯酸及其酯的化学结构中均有不饱和碳碳双键和羧基或羧基衍生的特性功能团，因此可广泛用于均聚反应和共聚反应，能与多种化合物反应，合成一系列丙烯酸共聚物。

The effects of styrene butadiene latex, polyester fiber,graphite and silicon powder on compressive strength and damping ratio of concrete were analyzed.

研究了羧基丁苯胶乳、聚酯纤维、石墨、硅粉等掺合料对混凝土的抗压强度和阻尼性能的影响，并对羧基丁苯胶乳、硅粉和石墨的作用机理进行了探讨。

Multilayer latex particles with carboxylic polymer as core, polymer with low glass transition temperature and film-formable under room temperature as shell, and lightly crosslinked polymer as intermediate layer were prepared with unsaturated carboxylic monomers by multistage seed emulsion polymerization. Finally, the room-temperature-film-formable polymer particles with hollow structure were obtained via the alkali treatment to the multilayer latex particles.

采用羧基单体进行多阶段的种于乳液聚合，制备了内核为带羧基的聚合物、最外层为易成膜的低玻璃化温度聚合物、中间为轻度交联中间隔离层的多层核壳结构乳胶粒，最后通过碱处理制成了具有室温成膜性的中空结构聚合物微粒。

Do you know, i need you to come back

你知道吗，我需要你回来

Yang yinshu、Wang xiangsheng、Li decang,The first discovery of haemaphysalis conicinna.

1〕 杨银书，王祥生，李德昌。安徽省首次发现嗜群血蜱。