羧基

Methods 4-Hydroxybenzonitrile (2) as the starting material was transformed to 4-hydroxy-thiobenzamide (3) via thioformylation. And ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate (4), which was synthesized via cyclization from 3, was treated with hexamethylenetetramine to generate the intermediate ethyl 2-(3-formyl-4-hydroxyphenyl)-4-methylthiazole-5-carboxylate (5). The target compound febuxostat (1) was obtained from 5 by etherification, cyanidation, hydrolysis.

以羟基苯腈为原料，经硫代甲酰化得到对羟基硫代苯甲酰胺(3)，3经环合得到2-（4-羟基苯基）－4-甲基－噻唑－5-羧酸乙酯(4)，4与乌洛托品反应，得到中间体2-（3-甲酰基－4-羟基苯基）－4-甲基－噻唑－5-羧酸乙酯(5)，之后再经醚化、氰化、水解得到目标产物(1)。

METHODS Polyaldehyde dextran-epirubicin was made by sodium periodate oxidation.Carboxy-methyldextran-epirubicin was made by chloroacetic acid carboxymethylation followed by conjugating in hydrazone bond.

采用高碘酸钠氧化法制备聚醛基葡聚糖-表柔比星偶合物，将葡聚糖羧甲基化后制备腙健连接的羧甲基葡聚糖-表柔比星偶合物。

A catalyst composition for the polymerization of propylene comprising one or more Ziegler-Natta procatalyst compositions comprising one or more transition metal compounds and one or more esters of aromatic dicarboxylic acid internal electron donors; one or more aluminum containing cocatalysts; a selectivity control agent comprising at least one silicon containing compound containing at least one C1-10 alkoxy group bonded to a silicon atom, and one or more activity limiting agent compounds comprising one or more aliphatic or cycloaliphatic carboxylic acids; alkyl-, cycloalkyl- or alkyl-ester derivatives thereof; or inertly substituted derivatives of the foregoing.

一种用于丙烯聚合的催化剂组合物，所述催化剂组合物包括：一种或多种齐格勒-纳塔主催化剂组合物，该主催化剂组合物包括一种或多种过渡金属化合物和一种或多种芳族二羧酸酯内部电子给体；一种或多种包含铝的助催化剂；选择性控制剂，该选择性控制剂包括至少一种包含硅的化合物，该化合物包括至少一种与硅原子连接的C 1-10 烷氧基；和一种或多种活性限制剂化合物，该活性限制剂包括一种或多种脂族或脂环族的单或聚羧酸类、其烷基-、环烷基-或烷基-衍生物、或上述惰性取代的衍生物。

Purified protein samples were separated by 2-DE with 17 cm IPG strips, and the protein spots were detected by fast silver staining. Six protein spots were randomly excised from the silver stained gel for primary analysis by MALDI-TOF MS. Four proteins were identified, and they were 1-aminocyclopropane-1-carboxylate synthase 2, ribulose-1, 5-bisphosphate carboxylase/oxygenase large subunit, F11O4.2 and Rubisco small subunit.

根据预实验结果，选用17 cm IPG预制干胶条对纯化的蛋白样品进行2-DE实验，采用快速银染法进行染色，随机挖取银染胶上6个蛋白点进行MALDI-TOF MS分析和数据库检索，鉴定了3个蛋白，它们是：1-氨基环丙烷-1羧酸合酶2，核酮糖-1，5-二磷酸羧化酶/加氧酶大亚基和F11O4.2。

The specific properties of materials, such as the palate adhesion, dynamic cruor, anti-bacterial and the degradability of lysozyme, were studied, which provide valuable data for further application. The main creative ideas are listed as follows:(1) The water-retention chitosan/poly vinyl alcohol blend fiber was obtained by coagulating in 10％ NaOH/ethanol solution, and the blend and crosslink due to GA can enhance the mechanical properties of fiber;(2) The controlled degradable chitosan/gelatin blend fiber was obtained by solution filature, and the mechanical properties were improved;(3) The N-acylchitosan with the different degree of substitution were successfully prepared, and the relationship between structure and properties was estabilished;(4) By a new solvent system of 6％ NaOH/4％ urea for cellulose, the blood anti-coagulant function films were prepared by blending cellulose with chitin;(5) In the same solvent system above mentioned, the anti-bacterial blend films based on cellulose and carboxymethyl-chitosan were prepared, and the relationship of DS and the anti-bacterial property was concluded;(6) The controlled degradable chitosan films was obtained by the chemical crosslink.

本论文的主要创新点：（1）以NaOH水溶液／无水乙醇为凝固液，采用溶液纺丝法制备出保水性壳聚糖／聚乙烯醇纤维，共混和戊二醛交联极大提高了壳聚糖纤维力学性能；（2）用壳聚糖和明胶共混，以溶液纺丝法制备出可控降解的壳聚糖／明胶纤维，并大幅度提高了壳聚糖共混纤维的干、湿态抗张强度；（3）确立了不同取代度N-酰基壳聚糖的合成方法及其膜的结构与性能的关系；（4）利用纤维素新溶剂6％NaOH／4％尿素制备出抗凝血性纤维素／甲壳素共混膜；（5）利用上述纤维素新溶剂制备出抗菌性纤维素／羧甲基壳聚糖共混膜，揭示了羧甲基壳聚糖取代度与抗菌性能的关系；（6）制备出可控降解壳聚糖交联膜。

It was found the levels of both large and small subunits were low at the albescent stage and became normal after leaves recovered to green, which corresponded with the enzyme activity change.

发现安吉白茶在返白与复绿过程中叶片可溶性蛋白的主要变化是RuBP羧化酶大、小亚基含量上的差异，这种差异与RuBP羧化酶活性的变化是相一致的。

The variation of large and small subunits of RuBPcase from temperature-sensitive mutant of Anjibaicha during its stage albescent process was investigated as well as the changes of the enzyme activities.

利用SDS-PAGE电泳分析了返白和复绿过程中各阶段叶片可溶性蛋白组分，尤其是RuBP羧化酶大、小亚基的变化，并利用同位素法测定了此过程中RuBP羧化酶活性的变化。

The enzyme histidine decarboxylase catalyses the conversion of histidine into histamine by removing the a-carboxylate group of the substrate.

这种酶组氨酸脱羧酶催化成通过消除组胺的基板1 -羧酸组的组氨酸转化。

The CMC grafted polyacrylamide co polyacrylic acid at the same time was produced. The redox system of patassium sulfate and sodium bisulfite was used as the initiator instead of the cerous ammonium nitrate because of its cheapness.

以羧甲基纤维素为基质，以过硫酸钾-亚硫酸氢钠氧化还原引发体系代替相对昂贵的硝酸铈铵引发剂，成功的制备了羧甲基纤维素同时接枝聚丙烯酰胺-聚丙烯酸共聚物。

The Carboxymethyl Cellulose grafted polyacrylamide was synthesized with the cerous ammonium nitrate as the initiator and the absorbent resin with excellent water absorbing abilities was produced through hydrolyzing the CMC-g-PAM.

以羧甲基纤维素为基质，以硝酸铈铵为引发剂，成功的制备了羧甲基纤维素接枝聚丙烯酰胺，进一步水解获得了具有优异吸水性能的高吸水树脂。

Do you know, i need you to come back

你知道吗，我需要你回来

Yang yinshu、Wang xiangsheng、Li decang,The first discovery of haemaphysalis conicinna.

1〕 杨银书，王祥生，李德昌。安徽省首次发现嗜群血蜱。