羟基酸

According to the result, we believed that the reason resulted in the low sensitivity was that the marker residue compound MQCA structure has changed after conjugated with protein and the antibody induced by the conjugation could not recognize the free MQCA in the ci-ELISA. Therefore we designed some hapten which could reserve the marker residue structural speciality mostly. After synthesis route selection and optimum, the hapten 7-Hydroxymethyl-3-methyl-quinoxaline-2-carboxylic acid was synthesized, used 4-methyl-2-nitroaniline as the start material via six steps, such as oxidation cyclization, bromize reaction, hydrolysis, Beirut reaction, reduction, hydrolysis. This work established basis for producing the high affinity antibody and developing the sensitive ELISA residue detection method.

本论文认为导致ELISA检测灵敏度较低的原因，是残留标示物和蛋白偶联后的特征结构发生改变，诱导产生的抗体不能够对游离MQCA很好的识别，因此，本论文设计了能够最大化保留MQCA结构特征的系列半抗原结构，并对其合成路线进行了筛选和优化，最终以对甲基邻硝基苯胺为起始原料，经氧化环化、溴代、水解、Beirut缩合、还原、水解六步反应制备含羟甲基结构的MQCA衍生物7-羟基甲基-3-甲基-喹噁啉-2-羧酸，为制备对游离残留标示物高亲和力的抗体，高灵敏度的ELISA残留检测方法的建立奠定基础。

Bis-(2,3-dibromo-4,5-dihydroxy-phenyl)-methane is a natural bromophenol with significant inhibition against PTP1B IC_(50=2.4μmol/L, which was isolated from the ethanol extract of red algae Rhodomela confervoides.

双-(2，3-二溴-4，5-二羟基苯基)-甲烷是从松节藻醇提物中分离鉴定出的溴酚类化合物，体外活性筛选发现，它具有极强的蛋白酪氨酸磷酸酶1B(PTP1B)抑制活性IC_(50=2.4μmol/L。

In comparison,the rhizobia in mature infected cells were larger,greater in number,varied in shape,and distributed throughout the nodule cells.The rhizobia in the mature cells also had poly-hydroxy butanoic acid and curapos.

成熟侵染细胞中，根瘤菌个体较大，数量较多，多呈棒状，少数为球形或椭球形，有很多根瘤菌还呈现明显的&T&形、&Y&形或&V&形，菌体占满了整个细胞，这时的根瘤菌大多数含有聚羟基丁酸和聚磷酸盐颗粒。

PKC and mitochondrial KATP channels were inhibited with chelerythrine and 5-hydroxydecanoate pretreatment, respectively.

试验中使用白屈菜红碱、5-羟基癸酸分别抑制心肌蛋白激酶 c 、线粒体 ATP 钾离子通道。

Chelerythrine and 5-hydroxydecanoate abolished cardioprotection in both SEVO and EtOH cardioprotected hearts.

白屈菜红碱、5-羟基癸酸在 EtOH 组和 SEVO 组中均能减弱原本的心肌保护作用。

The problems which existed in the D-p-hydroxyphenylglycine concentrative crystallization process are analyzed.

分析了对羟基左旋苯甘氨酸母液浓缩结晶过程存在的问题，介绍了三效热泵蒸发结晶工艺。

We have initially examined organocatalytic enantioselective synthesis ofα-Hydroxy phosphonates through the reaction of dialkyl phosphates and aldehydes.

我们初步实验了对映选择性的有机催化二烷基亚磷酸酯和醛的反应不对称合成α-羟基膦酸酯。

In this paper, kinetics and mechanism of oxidation of dihydric alcohols、 ethylene glycol monoethyl ether 、 amino acids by Ag in alkaline medium were studied by spectrophotometry.

本文用分光光度法研究了在碱性介质中，二羟基二合银配离子氧化二元醇、乙二醇独乙醚和天冬氨酸的反应动力学及机理。

Objective To observe the therapeutic effect of calcium dobesilate (calcium dihydroxy 2, 5-benzenesulfonate) on diabetes mellitus with early nephropathy in order to find a new therapeutic approach to diabetic nephropathy.

目的：观察2，5-二羟基苯磺酸钙对糖尿病早期肾病患者的疗效，为糖尿病肾病的治疗寻求新途径。

The present invention relates to a novel process for converting the intermediate in the synthesis of atorvastatin having the following formula or atorvastatin lactose into the non-crystalline atorvastatin calcium: wherein A denotes a common protection group or separate protection groups for the dihydroxy group and B denotes a carboxylic acid protection group.

本发明涉及一种将具有下式的阿托伐他汀合成中的中间体或阿托伐他汀乳糖转化为非结晶阿托伐他汀钙的新方法：其中A表示二羟基的共同保护基或单独保护基，而B表示羧酸保护基。

With Death guitarist Schuldiner adopting vocal duties, the band made a major impact on the scene.

随着死亡的吉他手Schuldiner接受主唱的职务，乐队在现实中树立了重要的影响。

But he could still end up breakfasting on Swiss-government issue muesli because all six are accused of nicking around 45 million pounds they should have paid to FIFA.

不过他最后仍有可能沦为瑞士政府&议事餐桌&上的一道早餐，因为这所有六个人都被指控把本应支付给国际足联的大约4500万英镑骗了个精光。