羟基酸

Then Doripenem came into the market in the July ,2005. We studied the synthesis of Doripemen.Firstly, we synthesized the chemical 2 from the starting material------o-hydroxylphenylacylamine through Reformastky reaction, alkylation, Diekmann reaction, enolization, esterification and etc. Secondly, we synthesized the chemical 3 from L — hydroxylproline through the protection of carboxyl, amidogen and hydroxyl group, reduction by NaBr, SN_2 substitution and Mitsumobu reaction.

我们以水杨酰胺为起始原料，经Reformatsky反应、烷基化、Diekmann环合、烯醇化、酯化等反应合成双环母核2；再从L-羟基脯氨酸出发，经酯化保护羧基、保护氨基、保护羟基、硼氢化还原酯得醇、Sn2取代和Mitsumobu反应等合成巯基侧链3；最后由化合物3经脱保护、水解得硫醇，和化合物2在二异丙基乙基胺的作用下缩合，最后Pd／C催化脱保护，历经16步反应最终得到产物多尼培南。

METHODS 3-methoxy-7α-methylestra-1,3,5(10)-trien-17β-ol was reducted with lithium and ammonia,then the intermediate was hydrolyzed in oxalic acid and reacted with malonic acid to get 3,3-dimethoxo-7α-methylestra-5(10)-en-17-ol(compound 4),which was oxidated by pyridium bichromate ,reacted with acetylene,and hydrolyzed in oxalic acid again to get the product tibolone.

方法以3-甲氧基-7α-甲基雌甾-1，3，5(10)-三烯-17β-羟基为起始原料经锂胺还原、草酸水解、缩酮化得3，3-二甲氧基-7α-甲基雌甾-5(10)-烯-17β-羟基(化合物4)，然后用温和的氧化剂重铬酸吡啶盐氧化、炔化、再水解得目的产物。

The cis novel bisoxazoline ligands L1-L4 have been synthesized through the treatment of new cis dihydroxy diamide with p-toluenesulfonyl chloride in the presence of catalytic quantity of 4--pyridine, and the cis dihydroxy diamide could be achieved from the condensation of the amino alcohols and cis cyclopropane dicarbonyl chloride prepared via oxidation and halogenation from cis-2,2-dimethyl-3-formylcyclopropanecarboxylate with DCC.

我们以蒈醛酸内酯为起始原料，经过氧化反应、酰氯化反应得到顺式环丙烷二酰氯，然后在二环己基碳二亚胺的催化下与相应的氨基醇反应合成了顺式二羟基酰胺，再用对甲苯磺酰氯将羟基活化，最后在二甲氨基吡啶的催化下关环合成顺式双噁唑啉配体L1～L4。

An exterior angle of a wall or other piece of masonry.

任何含有除自身的羟基外其他羟基的酸。

The myristic-2-hydroxy-3-propane sulfonic acid sodium salt was synthesized from sodium bisulfite, epichlorohydrin, sodium phosphate and myristic acid. The influence factors of temperature, amount of catalyst, reaction time and reactant ratio on conversion were studied.

以亚硫酸氢钠、环氧氯丙烷、磷酸钠和肉豆蒄酸等为原料，合成了肉豆蒄酸－2-羟基－3-磺酸钠丙酯，探索了反应温度、催化剂、反应时间、反应物物质的量比等因素对合成的影响。

Property : This product is a polymer composed of carboxyl, sulphonic, phosphonic . There is organophosphate in the chain and side chain, so it is of superior effect of scale-preventative and be of certain corrosion-proof effect.

5.1性能：本品是含有羧基、磺酸基、膦酸基羟基等基团的共聚物，由于它的直链上和部分支链端含有膦基酸，因此本共聚物具有优异的防垢性能，并具有一定的防腐蚀性能。

The OH-terminated linear aliphatic polyester polybutylene sebacate was synthesized by sebacic acid and butancdiol using solution polycondensation combined with melt polycondensation. The composition and construct characteristic of the product were analyzed by GPC, FT-IR and 1HNM.

以丁二酸和丁二醇为原料，采用溶液与熔融结合法合成了端羟基聚丁二酸丁二醇酯，用甲苯-2，4-二异氰酸酯对PBS封端，合成了线性遥爪型纸张增强剂TDI-PBS。

The results revealed that with the increasing ear of continuous C. sativus cropping soil vanillic acid, p-hydroxyhenzoic acid and ferulic acid accumulated gradually. The total amount of the three phenolic compounds reached 29. 8 mgkg^(-1) dry soil after 7 years cropping, being markedly higher than that after 1 or 3 years cropping. After treated with these compounds, the root length and stem width of C.

结果表明：土壤中香草酸、对羟基苯甲酸及阿魏酸随黄瓜连作年限增加而呈现积累趋势；在连作7年的大棚土壤中3种酚酸类物质总量达29.8mgkg^(-1)干土，显著高于连作1年和1年土壤中的含量；酚酸物质可使黄瓜幼苗根长及茎粗显著降低，使株高及干物质量略有下降。

The chlorin e6 7 and chiorin 11 were oxidized further with osmium oxide in the same oxidization condition to yield bateriochlorin 8 and 12, respectively.

卟吩醛2在碱性条件下转化为卟吩e6三甲酯7，2与烷基溴化镁的格氏反应给出脱镁叶绿酸醇9，选择高钌酸四丙基铵和N-甲基吗啉N-氧化物将3-位羟基氧化成羰基，所生成的卟吩二酮10在酸性条件下脱去甲酸甲酯生成焦脱镁叶绿酸衍生物11，用四氧化锇对7和11实施氧化，则分别转化为细菌卟吩衍生物8和12。

These include catechin and gallocatechin (hydroxyls at positions 5' as well as at 3' and 4' as in catechin), their esters with gallic acid, catechin gallate, and gallocatechin gallate, and their epimers.

它们有几茶素和儿茶素(在5'位上以及如同儿茶素中一样在3'和4'位上羟基化)，它们与酸生成的酯，即儿茶素酸酯和儿茶素酸酯，以及它们的差向异构体。

With Death guitarist Schuldiner adopting vocal duties, the band made a major impact on the scene.

随着死亡的吉他手Schuldiner接受主唱的职务，乐队在现实中树立了重要的影响。

But he could still end up breakfasting on Swiss-government issue muesli because all six are accused of nicking around 45 million pounds they should have paid to FIFA.

不过他最后仍有可能沦为瑞士政府&议事餐桌&上的一道早餐，因为这所有六个人都被指控把本应支付给国际足联的大约4500万英镑骗了个精光。