羟基酸

Ethyl 4-[(1-hydroxy-1-methyl)ethyl]-2-propyl-1H-imidazole-5-carboxylate,the key intermediate of Olmesartan ,was synthesized from butanoic acid and o-phenylenediamine via condensation under microwave-irradiation,oxidation,esterification and the Gringard reaction.

用正丁酸与邻苯二胺为原料，在微波照射下缩合成2-丙基苯并咪唑，再氧化开环制得2-丙基咪唑二羧酸，再经酯化、Gringard反应制得抗高血压药物奥美沙坦的关键中间体2-丙基-4-[(1-羟基-1-甲基)乙基]-1H-咪唑-5-羧酸乙酯，总收率32.2%。

The article in recent years the research progress of disease of oral cavity of TP prevention and cure makes one overview. The compositive TP of the basic research 1.1 TP of 1 TP is the floorboard that phenolic apperception of a kind of many hydroxyl closes matter, 25% what hold tea dry weight about, its are main component includes to express gallnut of gallnut catechu element gallnut of element of catechu of gallnut of acerbity ester, watch, watch catechu element is acerbity element of catechu of ester, watch, express gallnut of gallnut catechu element among them acerbity ester content is highest, occupy the 80%[1] of catechu element about, fighting oxidation with its unique element structure, fight the position with fight the respect such as tumor to have choppy, significant. The 1.2 TP absorption in oral cavity and metabolization Lee [2] is measured normally inside a hour after healthy person is chewing green tea Xie Huo contains juice of gargle green tea, content of the TP in saliva is very high, after observing green tea passes salivary enzymatic hydrolyze, TP is slow release and in oral cavity;Yang of local play action [the salivary level after 3] checked 6 volunteers to drink tea, chroma of the TP in making clear the saliva after drinking tea as a result is serous TP pH indicator 2 times, and the salivary TP concentration that contains gargle tea solution a few minutes to be able to produce higher level, and TP can be absorbed through oral cavity mucous membrane.

本文就近年来TP防治口腔疾病的探究进展作一综述。1 TP的基础探究1.1 TP的组成TP是一类多羟基酚类化合物的总称，约占茶叶干重的25%，其主要成份包括表没食子儿茶素没食子酸酯、表没食子儿茶素、表儿茶素没食子酸酯、表儿茶素等，其中表没食子儿茶素没食子酸酯含量最高，约占儿茶素的80%[1]，并以其独特的分子结构在抗氧化、抗突变、抗肿瘤等方面占有重要的地位。1.2 TP在口腔中的吸收和代谢Lee等[2]测得正常健康人在咀嚼绿茶叶或含漱绿茶液后的一个小时内，唾液中TP含量很高，并观察到绿茶通过唾液酶水解后，TP缓慢释放并在口腔局部发挥功能；Yang等[3]检查了6位志愿者饮茶后的唾液水平，结果表明饮茶后唾液中TP浓度是血浆TP浓度的2倍，而含漱茶溶液几分钟即可产生更高水平的唾液TP浓度，且TP可通过口腔黏膜吸收。

In order to obtain 3-methoxy-4-hydroxymandelic acid with high quality and high yield, guaiacol was condensed with glyoxylic acid in an alkaline aqueous solution using solid acid as catalyst. The reaction temperature and reaction time was 15℃ and 18 hours respectively.

为了得到高质量和高收率的3-甲氧基－4-羟基苯乙醇酸，使愈创木酚和乙醛酸在碱性水溶液中在固体酸催化剂存在下进行缩合反应，反应温度15℃，反应时间18h。

A method for forming an aqueous chlorine dioxide solution is disclosed which includes reacting in a reaction vessel an acid reaction solution containing a hydroxy carboxylic acid and a companion acid with an alkali metal salt of a chlorite ion.

本发明公开了一种生成含水的二氧化氯溶液的方法，其中包括在反应容器中让含有羟基羧酸和配对酸的酸的反应溶液与亚氯酸根离子的碱金属盐进行反应。

ABSTRACT Immobilized penicillin acylase (from E.coli) was used to catalyze 7 phenylacetamido 3 E propenyl cephalosporanic acid hydrolyzation into 7 amino 3 E propenyl cephalosporanic acid. Then, trans APRA was acylated with hydroxyethyl ester of 4 hydroxy D phenylglycine to obtain trans cefprozil.

以7 苯乙酰氨基 3 E 丙烯基 3 头孢菌素 4 羧酸为原料，在青霉素酰化酶作用下，首先酶法水解得到3 E 丙烯基 3 头孢菌素 4 羧酸，过滤固相酶，滤液调pH分离得到反式APRA固体；在青霉素酰化酶作用下，反式APRA再与对羟基苯甘氨酸乙二醇酯缩合，得到反式头孢丙烯；酶法合成所得的产品与进口反式头孢丙烯对照品一致。

And humic substance (fulvic acids, humic acids and humin). The features of fulvic acids of humic substance at the southwestern part of Turfan-Hami basin are: the content of C is low, and the content of H, S, O is relatively high, atomic number of C/H is low.

研究证实吐哈盆地腐殖质中黄腐酸的特点是C含量较低，H、S、O含量偏高，C/H原子数比较低；官能团分析证实黄腐酸的总酸基、羧基、酚羟基含量较高，反映出黄腐酸具有较高的活性。

In recent years, the company excellent location advantages, multi-introduction of advanced production equipment and technology to improve old products and develop new products to 12 - hydroxy acid-based rigid and at the same time the production of refined castor oil, hydrogenated castor oil, refined Gan oil, Sebacate methacrylate (annual output 1500 tons), dibutyl sebacate (annual output 1500 tons), octyl sebacate, anhydrous sodium sulfate, castor meal and other products.

近年来，公司以优越的区位优势，多方引进先进的生产设备和技术，改进旧产品，拓展新产品，以 12 －羟基硬质酸为主，又同时生产精炼蓖麻油、氢化蓖麻油，精甘油，癸二酸二甲酯（年产量 1500 吨），癸二酸二丁酯（年产量 1500 吨），癸二酸二辛酯，无水硫酸钠，蓖麻粕等产品。

The detected phenolic, gallic acid was gradually increased with continuous cropping years increasing, vanillic was steady in soil of different continupus cropping years, ferulic acids had more content in soil of five-year continuous cotton cropping, but remarkably reduced with ten-year continuous cropping.7 It was found that the p-hydrobenzoic, vanillic, gallic acid and ferulic acids in different comentration inhibited/stimulated the spore germination and mycelium growth of cotton verticillium wilt.

没食子酸含量随着连作年限增加在土壤中逐渐增加，香草醛在不同连作年限土壤中含量较稳定，而阿魏酸连作5年土壤中含量最高，连作10年时显著下降。7不同浓度的对-羟基苯甲酸、阿魏酸、香草醛和没食子酸对棉花黄萎病病菌孢子萌发和菌丝生长产生促进或抑制的化感作用。

Diamino-dipenylamine-2-sulfonicacid was used as an alternative of benzidine,and reacted withl-hy droxy-8-aminonaphthalene-3,6-dusuifonicacid,m-benzioc-diamine and aniline to synthesize eco-friendly black direct dye s.

报道了以4，4'-酸(4，4'-二氨基-二苯胺-2-磺酸)代替联苯胺，与H酸(1-羟基-8-氨基-3，6-二萘磺酸)、间苯二胺、苯胺等合成无致癌作用的环保型黑色直接染料。

Most sugars, organic acids, phenolic acids and most amino acids increased significantly with elevated CO_2. The treatment, 950±50μmol·mol-1 CO_2 enrichment for 6 h every day had more obvious effects than the treatment, 950±50μmol·mol-1 CO_2 enrichment for 3 h every day. Levan, sucrose, arginine, oxalic acid, alanine, malic acid, acetic acid, lactic acid cinnamic acid,ρ- hydroxybenzoic acid and benzoic acid increased significantly.

CO_2施肥黄瓜根系分泌有机酸、氨基酸、糖和酚酸的总量增加，上、下午均施肥的处理分泌数量最多；CO_2施肥显著促进了果聚糖、蔗糖、草酸、苹果酸、乙酸、乳酸、多数氨基酸、肉桂酸、对羟基苯甲酸和苯甲酸等组分的分泌；单位鲜重根系分泌糖和酚酸的数量增加，多数氨基酸保持不变或降低，但有机酸分泌规律不一致。

This one mode pays close attention to network credence foundation of the businessman very much.

这一模式非常关注商人的网络信用基础。

Cell morphology of bacterial ghost of Pasteurella multocida was observed by scanning electron microscopy and inactivation ratio was estimated by CFU analysi.

扫描电镜观察多杀性巴氏杆菌细菌幽灵和菌落形成单位评价遗传灭活率。