羟基酮

Results show that intramolecular hydrogen transfer is not favored in view of the energy trend along IHT coordinate in the region such as hypericin's peri region, where two hydrogens of hydroxyl groups bond with a common oxygen of carbonyl group and exists two IHBs in the peri region. However, intramolecular proton transfer often occur in the molecule with hexahydric cycle hydrogen bond, where only one pair of adjacent hydroxyl group and carbonyl group.

此外选择设计了一个具有三个分子内氢键的体系，兼具金丝桃蒽酮和其他苝醌类光敏剂的分子内氢键特点，研究表明两个羟基氢与共同的羰基氧形成的氢键由于存在较高的势垒，很难发生分子内氢传递，即具有金丝桃蒽酮端位结构的分子其分子内氢传递很难发生，而一般的能形成六元环状结构的分子内氢键体系容易发生分子内氢传递。

Investigation of major metabolic pathways of SFZ-47 in animals The metabolites of SFZ-47 in rabbit urine following oral administration were separated and detected with HPLC and LC-MS methods. On the basis of the chromatographic behavior and mass spectra of the metabolites as well as biotransformation pathways of drugs with the partial structure of SFZ-47, the hydroxylic derivative 4-(3H-1, 2- dihydro-1-pyrrolizinone-2-methylamino benzyl alcohol and the carboxylic derivative 4-(3H-1, 2-dihydro-1-pyrrolizinone-2-methylamino benzoic acid of SFZ-47 were proposed as two potential metabolites and were synthesized.

在动物体内主要代谢途径的确定用HPLC和LC-MS对家兔口服SFZ-47后尿中的代谢物进行了分离、检测，根据代谢产物的色谱和质谱行为以及与SFZ-47有类似结构部分的其它药物的代谢途径，推测其羟基衍生物[4-（3H-1，2-二氢-1-吡咯里嗪酮-2-甲基胺基）苯甲醇]与羧基衍生物[4-（3H-1，2-二氢-1-吡咯里嗪酮-2-甲基胺基）苯甲酸]是两种可能的代谢产物，遂用化学方法合成了这两种衍生物。

A series of 3 - aryl - 3 -( 5,5 - dimethyl - 3 - hydroxy - 2 - cyclohexene - 1 - one - 2 - yl) propanoic ester s were synthesized by reaction between aromatic aldehydes ,5,5- dimethyl -1,3-cyclohexanedione and isopropylidene malonate catalyzed by KF - Al2O3 in alcohols.

在KF-Al_2O_3催化下，将芳香醛3，5-二甲基-1，3-环己二酮及丙二酸亚异丙酯在醇中反应，一锅式合成了一系列的3-芳基-3-(5，5-二甲基-3-羟基-2-环己烯-1-酮-2-基)丙酸酯。

Moreover, the preliminary test of the biological activity of the 8 target derivatives showed that 7-(2-adenine)ethoxyl-2-ethyl-4"- methoxy isoflavone and 7-(2-hydroxyl-3-piperidino)propoxy-2-ethyl-4"- methoxyl isoflavone have fine biological activities on suppression of the growth of MCF-7 cell in breast cancer and the hela cell in cervical cancer of human being.

另外还对8个目标衍生物进行了初步的药理活性试验，发现7-(2-腺嘌呤)乙氧基-2-乙基-4′-甲氧基异黄酮和7-(2-羟基-3-哌啶)丙氧基-2-乙基-4′-甲氧基异黄酮均有较好的抑制人乳腺癌MCF-7细胞和人宫颈癌hela细胞生长的药理活性。

The highest total flavonoid rate was 1.127%. An all-round evaluation for the antioxidant activity of the flavonoids extract from zizania-bract was carried out with that of ascorbic acid as the control. The evaluation indexes included the cleanup rate of the polyphenolic extract towards superoxidized anionic radicals, hydroxyl radicals, DPPH free radicals, the deoxidizing ability, and the antioxidant activity towards the peroxidize of lipids and edible oils.

采用抗坏血酸作为对照，全面测定了茭白苞叶总黄酮对超氧阴离子自由基、羟基自由基、DPPH自由基的清除率，以及还原能力、抗脂质过氧化活性和对食用油脂的抗氧化性的影响，结果表明，白苞叶中的总黄酮是一种有开发价值的天然抗氧化剂。

This thesis is constituted by four parts: In the first part a summarization is given on the main total synthetic methods of isoflavones, for example, deoxybenzoin method which generally involves two steps wherein a phenol is reacted in the presence of a Lewis acid with phenylacetic acid to generate an intermediate deoxybenzoin which is then cyclized with a one carbon electrophile.

本论文主要工作包括四部分：第一章综述了近年来全合成异黄酮的主要方法：脱氧安息香法，是以多羟基苯酚与苯乙酸或苯乙腈在Lewis酸存在下，反应生成中间体脱氧安息香，然后再与亲电碳试剂进行关环反应生成异黄酮。

A series of novel polys: poly, poly and their copolymer poly were synthesized at high temperature by nucleophilic polycondensation of bisphenol 4 (3 phenyl 4 hydroxyphenyl) 2,3 phthalazin 1 one with activated difluorodiphenylketone, dichlorodiphenylsulfone and both together.

将苯基取代类双酚化合物 4-(3 -苯基-4-羟基苯基)-2 ，3 -二氮杂萘-1 -酮与活性双卤单体如 4，4 -二氟二苯酮、4，4 -二氯二苯砜进行高温缩聚反应，合成了高分子量的新型苯基取代杂萘联苯型聚芳醚材料；用1 H NMR、FT-IR表征了类双酚单体及聚合物的结构。

Total synthesis of bilobetin and isoginkgetin, natural polyhydroxy biflavones with a Ⅰ-3'/Ⅱ-8 dissymetrical connection, and synthesis of acetyl flavones were investigated in this dissertation.

本论文对天然多羟基不对称连接的双黄酮-白果素、异银杏素的合成以及乙酰基黄酮的合成进行了研究，共包括以下内容

With CYP1A2, 3-fold enhancement in actiity per cell was seen for conerting ethoxyresorufin to resorufin compared to C3A cell monolayers.

结果发现，每个细胞中CYP1A2将乙氧基-异吩唑酮转化为9-羟基-3-异吩恶唑酮的能力相对于单细胞层的C3A细胞增强了3倍。

In addition, rutin has many other functions, such as anti-inflammatory, antiallergic, diuretic, spasmolytic, reducing blood-fat, cardiotonic, protecting ulcer surfaces, etc. Therefore it has been used in clinical treatment.

芦丁，3，3′，4′，5，7，—五羟基黄酮-3-芸香糖苷，又名芸香苷，是一种从植物中提取得黄酮类化合物，无论在什么条件下，都具有多方面的生理活性和电化学活性。

This one mode pays close attention to network credence foundation of the businessman very much.

这一模式非常关注商人的网络信用基础。

Cell morphology of bacterial ghost of Pasteurella multocida was observed by scanning electron microscopy and inactivation ratio was estimated by CFU analysi.

扫描电镜观察多杀性巴氏杆菌细菌幽灵和菌落形成单位评价遗传灭活率。